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Gene Information
Gene ID:40263
Symbol:CG11796
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:77C3-77C3
Physical Location:20431254-20432967 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3242    Symbol (Name): HPD (4-hydroxyphenylpyruvate dioxygenase)
Ortholog Status:The human GeneID 3242 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG11796
P Value:2.41E-02
Note:Transient up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_140968.2NP_649225.1NT_037436.3 range: 20431254..20432967, complement
NM_168857.1NP_730536.1NT_037436.3 range: 20431254..20432967, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:00038684-hydroxyphenylpyruvate dioxygenase activityMolecular FunctionISS
GO:0009072aromatic amino acid family metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:40263
FLYBASE:FBgn0036992