ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NEK1

Full Name:

NIMA (never in mitosis gene a)-related kinase 1

Alias:

DKFZp686D06121|DKFZp686K12169|KIAA1901|MGC138800|NY-REN-55

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q33

Physical Location:

170551003-170770188 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18004 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.481181
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012224.1	NP_036356.1	NC_000004.10 range: 170551003..170770188, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15604234)
GO:0005737	cytoplasm	Cellular Component	IDA (15604234)
GO:0005575	cellular_component	Cellular Component	ND
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14690447\|15231747)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS (8274451)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (8274451)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0051301	cell division	Biological Process	IEA