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Gene Information
Gene ID:4852
Full Name:neuropeptide Y
Organism:Homo sapiens (Human)
Genetic Location:7p15.1
Physical Location:24290333-24298001 on NC_000007.12
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:K01911
Dataset Information
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Information
Original ID1:NPY
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:NPY
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
NPY2Alcohol-Induced Disorders
NPY2Alcohol-Induced Disorders Nervous System
NPY8Alcohol-Related Disorders
NPY2Alcohol Withdrawal Delirium
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000905.2NP_000896.1NC_000007.12 range: 24290333..24298001
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005623cellCellular ComponentTAS (2444979)
GO:0005615extracellular spaceCellular ComponentISS
GO:0005576extracellular regionCellular ComponentIEA
GO:0004930G-protein coupled receptor activityMolecular FunctionTAS (1321422)
GO:0005246calcium channel regulator activityMolecular FunctionTAS (8132547)
GO:0005184neuropeptide hormone activityMolecular FunctionTAS (2427515)
GO:0008343adult feeding behaviorBiological ProcessISS
GO:0008283cell proliferationBiological ProcessTAS (10488139)
GO:0008015blood circulationBiological ProcessNAS (8421707)
GO:0007586digestionBiological ProcessNAS (8421707)
GO:0007268synaptic transmissionBiological ProcessTAS (10557353)
GO:0007218neuropeptide signaling pathwayBiological ProcessIEA
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerBiological ProcessTAS (8132547)
GO:0006928cell motilityBiological ProcessTAS (10488139)
GO:0006816calcium ion transportBiological ProcessTAS (8132547)
GO:0032100positive regulation of appetiteBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:4852
HuGE Navigator:4852