ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Trfr2

Full Name:

transferrin receptor 2

Alias:

Tfr2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 G2

Physical Location:

138011078-138028708 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7036 Symbol (Name): TFR2 (transferrin receptor 2)

Ortholog Status:

The human GeneID 7036 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Trfr2
Original ID2:		AI596094

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_015799.3	NP_056614.3	NC_000071.5 range: 138011078..138028708

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISS (10681454)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004998	transferrin receptor activity	Molecular Function	TAS (10681454)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0006879	cellular iron ion homeostasis	Biological Process	TAS (10681454)