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Gene Information
Gene ID:50765
Full Name:transferrin receptor 2
Organism:Mus musculus (Mouse)
Genetic Location:5 G2
Physical Location:138011078-138028708 on NC_000071.5
Gene Type:protein-coding
Human Ortholog:GeneID: 7036    Symbol (Name): TFR2 (transferrin receptor 2)
Ortholog Status:The human GeneID 7036 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Trfr2
Original ID2:AI596094
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_015799.3NP_056614.3NC_000071.5 range: 138011078..138028708
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentISS (10681454)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0004872receptor activityMolecular FunctionIEA
GO:0004998transferrin receptor activityMolecular FunctionTAS (10681454)
GO:0008233peptidase activityMolecular FunctionIEA
GO:0006508proteolysisBiological ProcessIEA
GO:0006879cellular iron ion homeostasisBiological ProcessTAS (10681454)
Other Database Cross Links
NCBI Entrez Gene:50765