ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ENPP2

Full Name:

ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q24.1

Physical Location:

120638499-120720286 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 84050 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L46720
Fold Change:		-1.6, -1.8
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

BE700679

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (8579579)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (1733949)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	TAS (7982964)
GO:0008134	transcription factor binding	Molecular Function	TAS (8586446)
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	Molecular Function	IEA
GO:0004551	nucleotide diphosphatase activity	Molecular Function	TAS (8579579)
GO:0004528	phosphodiesterase I activity	Molecular Function	TAS (7982964)
GO:0004519	endonuclease activity	Molecular Function	IEA
GO:0006796	phosphate metabolic process	Biological Process	TAS (8579579)
GO:0006935	chemotaxis	Biological Process	NAS (7982964)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (1733949)
GO:0008152	metabolic process	Biological Process	IEA
GO:0016042	lipid catabolic process	Biological Process	IEA
GO:0006928	cell motility	Biological Process	TAS (1733949)