ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ramp3

Full Name:

receptor (calcitonin) activity modifying protein 3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q21

Physical Location:

87417289-87434788 on NC_005113.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10268 Symbol (Name): RAMP3 (receptor (G protein-coupled) activity modifying protein 3)

Ortholog Status:

The human GeneID 10268 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ramp3
Fold Change:		-1.14
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Ramp3
Fold Change:		-1.14
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Ramp3
Fold Change:		1.3
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020100.2	NP_064485.2	NC_005113.2 range: 87417289..87434788

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0001664	G-protein-coupled receptor binding	Molecular Function	NAS (11556887)
GO:0015027	coreceptor, soluble ligand activity	Molecular Function	ISS
GO:0015027	coreceptor, soluble ligand activity	Molecular Function	IDA (11556887)
GO:0008565	protein transporter activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	NAS (11556887)
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	ISS
GO:0006886	intracellular protein transport	Biological Process	IEA