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Gene Information
Gene ID:58853
Symbol:Nr4a3
Full Name:nuclear receptor subfamily 4, group A, member 3
Alias:NOR-2
Organism:Rattus norvegicus (Rat)
Chromosome:5
Genetic Location:5q22
Physical Location:64713467-64753310 on NC_005104.2
Gene Type:protein-coding
Human Ortholog:GeneID: 8013    Symbol (Name): NR4A3 (nuclear receptor subfamily 4, group A, member 3)
Ortholog Status:The human GeneID 8013 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Nr4a3
Fold Change:1.28
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Nr4a3
Fold Change:1.56
P Value:0
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Nr4a3
Fold Change:1.3
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in amygdala
Gene Information
Original ID1:Nr4a3
Fold Change:1.56
P Value:0
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017352.1NP_059048.1NC_005104.2 range: 64713467..64753310
NM_031628.1NP_113816.1NC_005104.2 range: 64713467..64753310
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0003677DNA bindingMolecular FunctionIDA (7556683)
GO:0001707mesoderm formationBiological ProcessISS
GO:0031100organ regenerationBiological ProcessIEP (7556683)
GO:0043434response to peptide hormone stimulusBiological ProcessIEP (7556683)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:58853
RGD:61882
Ensembl:ENSRNOG00000005964
dbSNP:Nr4a3