ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nr4a3

Full Name:

nuclear receptor subfamily 4, group A, member 3

Alias:

NOR-2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q22

Physical Location:

64713467-64753310 on NC_005104.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8013 Symbol (Name): NR4A3 (nuclear receptor subfamily 4, group A, member 3)

Ortholog Status:

The human GeneID 8013 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nr4a3
Fold Change:		1.28
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Nr4a3
Fold Change:		1.56
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Nr4a3
Fold Change:		1.3
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in amygdala

Gene Information

Original ID1:		Nr4a3
Fold Change:		1.56
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0003677	DNA binding	Molecular Function	IDA (7556683)
GO:0001707	mesoderm formation	Biological Process	ISS
GO:0031100	organ regeneration	Biological Process	IEP (7556683)
GO:0043434	response to peptide hormone stimulus	Biological Process	IEP (7556683)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS