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Gene Information
Gene ID:8013
Symbol:NR4A3
Full Name:nuclear receptor subfamily 4, group A, member 3
Alias:CHN|CSMF|MINOR|NOR1|TEC
Organism:Homo sapiens (Human)
Chromosome:9
Genetic Location:9q22
Physical Location:101623957-101668993 on NC_000009.10
Gene Type:protein-coding
Orthologs:This gene has Rat: 58853 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.279522
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006981.2NP_008912.2NC_000009.10 range: 101623957..101668993
NM_173198.1NP_775290.1NC_000009.10 range: 101623957..101668993
NM_173199.1NP_775291.1NC_000009.10 range: 101623957..101668993
NM_173200.1NP_775292.1NC_000009.10 range: 101623957..101668993
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS (8634690)
GO:0005634nucleusCellular ComponentIEA
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005488bindingMolecular FunctionTAS (9573341)
GO:0004887thyroid hormone receptor activityMolecular FunctionTAS (8570200)
GO:0004879ligand-dependent nuclear receptor activityMolecular FunctionIEA
GO:0003707steroid hormone receptor activityMolecular FunctionTAS (8570200)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:8013
HGNC:7982
Ensembl:ENSG00000119508
MIM:600542
HPRD:02766
HuGE Navigator:8013
dbSNP:NR4A3
GeneCard:NR4A3
AceView:NR4A3