ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NR4A3

Full Name:

nuclear receptor subfamily 4, group A, member 3

Alias:

CHN|CSMF|MINOR|NOR1|TEC

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q22

Physical Location:

101623957-101668993 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 58853 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.279522
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS (8634690)
GO:0005634	nucleus	Cellular Component	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	TAS (9573341)
GO:0004887	thyroid hormone receptor activity	Molecular Function	TAS (8570200)
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	TAS (8570200)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND