ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLSTN2

Full Name:

calsyntenin 2

Alias:

ALC-GAMMA|CS2|CSTN2|FLJ39113|FLJ39499|MGC119560|alcagamma

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3q23-q24

Physical Location:

141136896-141769327 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 171394 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.158529
Note:		"Class I, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022131.1	NP_071414.1	NC_000003.10 range: 141136896..141769327

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0007156	homophilic cell adhesion	Biological Process	IEA