ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SPARC

Full Name:

secreted protein, acidic, cysteine-rich (osteonectin)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q31.3-q32

Physical Location:

151021200-151046709 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20692 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		SPARC
Original ID2:		T54767

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Information

Original ID1:

SPARC

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003118.2	NP_003109.1	NC_000005.8 range: 151021200..151046709, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	EXP (1737102)
GO:0005576	extracellular region	Cellular Component	NAS (14718574)
GO:0005604	basement membrane	Cellular Component	IEA
GO:0031093	platelet alpha granule lumen	Cellular Component	EXP (1737102)
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	TAS (7034958)
GO:0005518	collagen binding	Molecular Function	TAS (7034958)
GO:0001503	ossification	Biological Process	TAS (7034958)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (15609325)