| Gene Information |
| Gene ID: | | 71853 |
| Symbol: | | Pdia6 |
| Full Name: | | protein disulfide isomerase associated 6 |
| Alias: | | 1700015E05Rik|AL023058|C77895|CaBP5|P5|Txndc7 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 12 |
| Genetic Location: | | 12 A1.1 |
| Physical Location: | | 17273400-17291575 on NC_000078.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 10130 Symbol (Name): PDIA6 (protein disulfide isomerase family A, member 6) |
| Ortholog Status: | | The human GeneID 10130 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AW045202 | | Note: | | Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains |
| | Dataset Information | | Name: | | 15282116 | | Method: | | Microarray | | Tissue: | | Striata | | Phenotype: | | Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration | | Publication: | | Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed | | Summary: | | Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By. |
| | Gene Information | | Original ID1: | | Txndc7 | | Original ID2: | | AI842377 |
| | Gene Information | | Original ID1: | | Txndc7 | | Original ID2: | | AW045202 |
| | Dataset Information | | Name: | | 15745951 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, prefrontal cortex, and ventral tegmental area | | Phenotype: | | Acute ethanol response | | Publication: | | Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed | | Summary: | | The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0003756 | protein disulfide isomerase activity | Molecular Function | IEA | |
| GO:0016853 | isomerase activity | Molecular Function | IEA | |
| GO:0045454 | cell redox homeostasis | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 71853 |
| MGI: | |
| Ensembl: | | ENSMUSG00000020571 |
| dbSNP: | | Pdia6 |
| AceView: | | Pdia6 |
