ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

79237

Symbol:

Hhex

Full Name:

hematopoietically expressed homeobox

Alias:

Hex

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q53

Physical Location:

241736541-241742128 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3087 Symbol (Name): HHEX (hematopoietically expressed homeobox)

Ortholog Status:

The human GeneID 3087 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hhex
Fold Change:		1.17
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024385.1	NP_077361.1	NC_005100.2 range: 241736541..241742128

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	TAS (10085234)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008190	eukaryotic initiation factor 4E binding	Molecular Function	ISS
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0016565	general transcriptional repressor activity	Molecular Function	IDA (10085234)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0035050	embryonic heart tube development	Biological Process	ISS
GO:0042127	regulation of cell proliferation	Biological Process	ISS
GO:0030900	forebrain development	Biological Process	ISS
GO:0030878	thyroid gland development	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	IDA (10085234)
GO:0030097	hemopoiesis	Biological Process	TAS (10085234)
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Biological Process	ISS
GO:0016525	negative regulation of angiogenesis	Biological Process	ISS
GO:0010553	negative regulation of specific transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0007049	cell cycle	Biological Process	ISS
GO:0006406	mRNA export from nucleus	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0001889	liver development	Biological Process	ISS