ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HHEX

Full Name:

hematopoietically expressed homeobox

Alias:

HEX|HMPH|HOX11L-PEN|PRH|PRHX

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q23.33

Physical Location:

94439660-94445387 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15242 Rat: 79237 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		PRHX
Original ID2:		X67235

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002729.4	NP_002720.1	NC_000010.9 range: 94439660..94445387

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IDA (12554669\|12826010)
GO:0003700	transcription factor activity	Molecular Function	TAS (10871399)
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	ISS
GO:0008190	eukaryotic initiation factor 4E binding	Molecular Function	IDA (12554669)
GO:0008134	transcription factor binding	Molecular Function	IPI (15016828)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Biological Process	IDA (15016828)
GO:0030177	positive regulation of Wnt receptor signaling pathway	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0016525	negative regulation of angiogenesis	Biological Process	IDA (15016828)
GO:0010553	negative regulation of specific transcription from RNA polymerase II promoter	Biological Process	IDA (10871399\|15016828)
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	Biological Process	IDA (12655000)
GO:0009952	anterior/posterior pattern formation	Biological Process	ISS
GO:0006406	mRNA export from nucleus	Biological Process	IDA (12554669)
GO:0007049	cell cycle	Biological Process	IDA (12554669)
GO:0008283	cell proliferation	Biological Process	IDA (12554669)