ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Grb2

Full Name:

growth factor receptor bound protein 2

Alias:

MGC108668

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q32.3

Physical Location:

105722013-105818648 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2885 Symbol (Name): GRB2 (growth factor receptor-bound protein 2)

Ortholog Status:

The human GeneID 2885 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Grb2
Fold Change:		-1.14
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_030846.2	NP_110473.2	NC_005109.2 range: 105722013..105818648, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	ISS
GO:0012506	vesicle membrane	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005154	epidermal growth factor receptor binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005070	SH3/SH2 adaptor activity	Molecular Function	ISS
GO:0051219	phosphoprotein binding	Molecular Function	IPI (8910399)
GO:0043560	insulin receptor substrate binding	Molecular Function	ISS
GO:0043560	insulin receptor substrate binding	Molecular Function	IPI (12891559)
GO:0001784	phosphotyrosine binding	Molecular Function	IPI (9271418)
GO:0000165	MAPKKK cascade	Biological Process	ISS
GO:0008286	insulin receptor signaling pathway	Biological Process	ISS
GO:0007568	aging	Biological Process	IPI (11954667)
GO:0007265	Ras protein signal transduction	Biological Process	TAS (7775428)
GO:0051291	protein heterooligomerization	Biological Process	IDA (15272025)