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Gene Information
Gene ID:81504
Full Name:growth factor receptor bound protein 2
Organism:Rattus norvegicus (Rat)
Genetic Location:10q32.3
Physical Location:105722013-105818648 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2885    Symbol (Name): GRB2 (growth factor receptor-bound protein 2)
Ortholog Status:The human GeneID 2885 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Grb2
Fold Change:-1.14
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_030846.2NP_110473.2NC_005109.2 range: 105722013..105818648, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentISS
GO:0012506vesicle membraneCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005154epidermal growth factor receptor bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005070SH3/SH2 adaptor activityMolecular FunctionISS
GO:0051219phosphoprotein bindingMolecular FunctionIPI (8910399)
GO:0043560insulin receptor substrate bindingMolecular FunctionISS
GO:0043560insulin receptor substrate bindingMolecular FunctionIPI (12891559)
GO:0001784phosphotyrosine bindingMolecular FunctionIPI (9271418)
GO:0000165MAPKKK cascadeBiological ProcessISS
GO:0008286insulin receptor signaling pathwayBiological ProcessISS
GO:0007568agingBiological ProcessIPI (11954667)
GO:0007265Ras protein signal transductionBiological ProcessTAS (7775428)
GO:0051291protein heterooligomerizationBiological ProcessIDA (15272025)
Other Database Cross Links
NCBI Entrez Gene:81504