ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PIP4K2B

Full Name:

phosphatidylinositol-5-phosphate 4-kinase, type II, beta

Alias:

PI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q12

Physical Location:

34175469-34209683 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 89812 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.260603
Note:		"Class I, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003559.4	NP_003550.1	NC_000017.9 range: 34175469..34209683, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	NR
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Molecular Function	IEA
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Molecular Function	IDA (9038203)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005057	receptor signaling protein activity	Molecular Function	TAS (9038203)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	TAS (9038203)
GO:0046488	phosphatidylinositol metabolic process	Biological Process	IEA