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Gene Information
Gene ID:8396
Full Name:phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Organism:Homo sapiens (Human)
Genetic Location:17q12
Physical Location:34175469-34209683 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 89812 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.260603
Note:"Class I, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003559.4NP_003550.1NC_000017.9 range: 34175469..34209683, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentNR
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activityMolecular FunctionIEA
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activityMolecular FunctionIDA (9038203)
GO:0016301kinase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005057receptor signaling protein activityMolecular FunctionTAS (9038203)
GO:0007166cell surface receptor linked signal transductionBiological ProcessTAS (9038203)
GO:0046488phosphatidylinositol metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:8396
HuGE Navigator:8396