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Gene Information
Gene ID:89812
Full Name:phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Organism:Rattus norvegicus (Rat)
Genetic Location:10q31
Physical Location:86464210-86490406 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8396    Symbol (Name): PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase, type II, beta)
Ortholog Status:The human GeneID 8396 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pip5k2b
Fold Change:-1.21
P Value:0.008
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053550.1NP_446002.1NC_005109.2 range: 86464210..86490406, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activityMolecular FunctionIEA
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activityMolecular FunctionISS
GO:0016301kinase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0046488phosphatidylinositol metabolic processBiological ProcessIEA
GO:0046488phosphatidylinositol metabolic processBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:89812