ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

84575

Symbol:

Fads1

Full Name:

fatty acid desaturase 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q43

Physical Location:

212670770-212685711 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3992 Symbol (Name): FADS1 (fatty acid desaturase 1)

Ortholog Status:

The human GeneID 3992 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fads1
Fold Change:		1.19
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053445.2	NP_445897.2	NC_005100.2 range: 212670770..212685711

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (7770068)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IDA (8177224)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	ISS
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Molecular Function	IDA (11414679)
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0019369	arachidonic acid metabolic process	Biological Process	IMP (11414679)
GO:0032868	response to insulin stimulus	Biological Process	IEP (16099631)
GO:0014070	response to organic cyclic substance	Biological Process	IEP (16099631)
GO:0010033	response to organic substance	Biological Process	IEP (11841597)
GO:0009744	response to sucrose stimulus	Biological Process	IEP (14506836)
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA
GO:0006636	unsaturated fatty acid biosynthetic process	Biological Process	IDA (11414679)
GO:0006636	unsaturated fatty acid biosynthetic process	Biological Process	ISS
GO:0006810	transport	Biological Process	IEA
GO:0006950	response to stress	Biological Process	IEP (8115350)
GO:0007568	aging	Biological Process	IEP (8487621)
GO:0007584	response to nutrient	Biological Process	IEP (16333142)
GO:0009267	cellular response to starvation	Biological Process	ISS
GO:0033189	response to vitamin A	Biological Process	IEP (11414679)