ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

UBE2M

Full Name:

ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)

Alias:

UBC-RS2|UBC12|hUbc12

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.43

Physical Location:

63758890-63762154 on NC_000019.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22192 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.406068
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003969.3	NP_003960.1	NC_000019.8 range: 63758890..63762154, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IMP (15694336)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	TAS (9694792)
GO:0005515	protein binding	Molecular Function	IPI (15361859)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0018169	ribosomal S6-glutamic acid ligase activity	Molecular Function	IDA (15361859)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0051246	regulation of protein metabolic process	Biological Process	IEA