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Gene Information
Gene ID:933
Symbol:CD22
Full Name:CD22 molecule
Alias:FLJ22814|MGC130020|SIGLEC-2|SIGLEC2
Organism:Homo sapiens (Human)
Chromosome:19
Genetic Location:19q13.1
Physical Location:40511918-40530103 on NC_000019.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X98405
Dataset Information
Name:12065639
Method:Microarray
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Information
Original ID1:M29273
Fold Change:2.1
Dataset Information
Name:15236863
Method:Microarray
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Information
Original ID1:CD22
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001771.2NP_001762.2NC_000019.8 range: 40511918..40530103
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentNR
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentTAS (8496602)
GO:0005515protein bindingMolecular FunctionIPI (8627166|8647200)
GO:0005529sugar bindingMolecular FunctionIEA
GO:0006955immune responseBiological ProcessTAS (8496602)
GO:0016337cell-cell adhesionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:933
HGNC:1643
Ensembl:ENSG00000012124
MIM:107266
HPRD:00114
HuGE Navigator:933
dbSNP:CD22
GeneCard:CD22
AceView:CD22