| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1588 |
Name | CYP19A1 |
Synonym | ARO|ARO1|CPV1|CYAR|CYP19|CYPXIX|P-450AROM;cytochrome P450, family 19, subfamily A, polypeptide 1;CYP19A1;cytochrome P450, family 19, subfamily A, polypeptide 1 |
Definition | aromatase|cytochrome P-450AROM|cytochrome P450 19A1|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthase|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase |
Position | 15q21.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Personal communication to Dr. Eric D. Austin. |
PH | The study sample included 31 cases and 104 controls. Twenty-nine SNPs in 15 candidate genes were associated with the risk of PPHTN (P < 0.05). Multiple SNPs in the genes coding for estrogen receptor 1, aromatase, phosphodiesterase 5, angiopoietin 1, and calcium binding protein A4 were associated with the risk of PPHTN. |
| More detail of all Human literatures about CYP19A1 | |
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Pathways and Diseases |
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Pathway | Steroid hormone biosynthesis;KEGG PATHWAY;hsa00140 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | estrogen biosynthesis;BioCyc;PWY66-380 |
Pathway | Estrogen biosynthesis;PID Reactome;500777 |
Pathway | Endogenous sterols;PID Reactome;500195 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Disease | Height;NHGRI |
Disease | menopause;GAD |
Disease | adult male height;GAD |
Disease | Polyarthritis;FunDO |
Disease | Uterine disease;FunDO |
Disease | Breast cancer;FunDO |
Disease | DEVELOPMENTAL;GAD |
Disease | Osteoporosis, Postmenopausal;GAD |
Disease | Prostate cancer;FunDO |
Disease | endometriosis;GAD |
Disease | Aromatase excess syndrome;OMIM |
Disease | fractures;GAD |
Disease | prostate cancer;GAD |
Disease | hormone disturbance;GAD |
Disease | Infiltrating cancer;FunDO |
Disease | Urogenital abnormalities;FunDO |
Disease | METABOLIC;GAD |
Disease | bone density;GAD |
Disease | fractures, vertebral;GAD |
Disease | REPRODUCTION;GAD |
Disease | CANCER;GAD |
Disease | Adrenal gland tumor;FunDO |
Disease | Female pseudohermaphroditism;GAD |
Disease | Endometriosis;FunDO |
Disease | height;GAD |
Disease | Hypertension;FunDO |
Disease | bone mass;GAD |
Disease | diabetes, type 2 insulin metabolic syndrome;GAD |
Disease | aromatase excess syndrome;GAD |
Disease | Osteoporosis;FunDO |
Disease | breast cancer;GAD |
Disease | Ovarian cancer;FunDO |
Disease | Obesity;FunDO |
Disease | endometrial cancer;GAD |
Disease | Aromatase deficiency;OMIM |
Disease | prostate carcinoma;GAD |
Disease | Hyperandrogenism;GAD |
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External Links |
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Links to Entrez Gene | 1588 |
Links to all GeneRIF Items | 1588 |
Links to iHOP | 1588 |
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Sequence Information |
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Nucleotide Sequence |
>1588 : length: 1512 atggttttggaaatgctgaacccgatacattataacatcaccagcatcgtgcctgaagcc atgcctgctgccaccatgccagtcctgctcctcactggcctttttctcttggtgtggaat tatgagggcacatcctcaataccaggtcctggctactgcatgggaattggacccctcatc tcccacggcagattcctgtggatggggatcggcagtgcctgcaactactacaaccgggta tatggagaattcatgcgagtctggatctctggagaggaaacactcattatcagcaagtcc tcaagtatgttccacataatgaagcacaatcattacagctctcgattcggcagcaaactt gggctgcagtgcatcggtatgcatgagaaaggcatcatatttaacaacaatccagagctc tggaaaacaactcgacccttctttatgaaagctctgtcaggccccggccttgttcgtatg gtcacagtctgtgctgaatccctcaaaacacatctggacaggttggaggaggtgaccaat gaatcgggctatgtggacgtgttgacccttctgcgtcgtgtcatgctggacacctctaac acgctcttcttgaggatccctttggacgaaagtgctatcgtggttaaaatccaaggttat tttgatgcatggcaagctctcctcatcaaaccagacatcttctttaagatttcttggcta tacaaaaagtatgagaagtctgtcaaggatttgaaagatgccatagaagttctgatagca gaaaaaagacgcaggatttccacagaagagaaactggaagaatgtatggactttgccact gagttgattttagcagagaaacgtggtgacctgacaagagagaatgtgaaccagtgcata ttggaaatgctgatcgcagctcctgacaccatgtctgtctctttgttcttcatgctattt ctcattgcaaagcaccctaatgttgaagaggcaataataaaggaaatccagactgttatt ggtgagagagacataaagattgatgatatacaaaaattaaaagtgatggaaaacttcatt tatgagagcatgcggtaccagcctgtcgtggacttggtcatgcgcaaagccttagaagat gatgtaatcgatggctacccagtgaaaaaggggacaaacattatcctgaatattggaagg atgcacagactcgagtttttccccaaacccaatgaatttactcttgaaaattttgcaaag aatgttccttataggtactttcagccatttggctttgggccccgtggctgtgcaggaaag tacatcgccatggtgatgatgaaagccatcctcgttacacttctgagacgattccacgtg aagacattgcaaggacagtgtgttgagagcatacagaagatacacgacttgtccttgcac ccagatgagactaaaaacatgctggaaatgatctttaccccaagaaactcagacaggtgt ctggaacactag |
Protein Sequence |
>1588 : length: 503 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH PDETKNMLEMIFTPRNSDRCLEH |