Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2837

Name

UTS2R

Synonym

GPR14|UR-2-R|UTR|UTR2;urotensin 2 receptor;UTS2R;urotensin 2 receptor

Definition

G protein-coupled receptor 14|G-protein coupled receptor 14|UR-II-R|urotensin II receptor|urotensin-2 receptor

Position

17q25.3

Gene Type

protein-coding

PAH Type

Description

PH

The dynamic changes of urotensin II receptor in pulmonary arterioles might have an important contribution to the development of pulmonary hypertension and pulmonary arteriole remodeling induced by chronic hypoxia-hypercapnia in rats.

PH

The expression of U II and Uts2R in right ventricle arteries and right ventricle myocytes increases significantly during the formation of pulmonary hypertension and right ventricle hypertrophy in rats chronically exposed to hypoxia-hypercapnia.
More detail of all Rat literatures about UTS2R

Pathways and Diseases

Pathway

Signaling by GPCR;Reactome;REACT:14797

Pathway

Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080

Pathway

Peptide ligand-binding receptors;PID Reactome;500405

Disease

METABOLIC;GAD

Disease

glucose tolerance insulin;GAD

External Links

Links to Entrez Gene

2837

Links to all GeneRIF Items

2837

Links to iHOP

2837

Sequence Information

Nucleotide Sequence

>2837 : length: 1170
atggcgctgacccccgagtccccgagcagcttccctgggctggccgccaccggcagctct
gtgccggagccgcctggcggccccaacgcaaccctcaacagctcctgggccagcccgacc
gagcccagctccctggaggacctggtggccacgggcaccattgggactctgctgtcggcc
atgggcgtggtgggcgtggtgggcaacgcctacacgctggtggtcacctgccgctccctg
cgtgcggtggcctccatgtacgtctacgtggtcaacctggcgctggccgacctgctgtac
ctgctcagcatccccttcatcgtggccacctacgtcaccaaggagtggcacttcggggac
gtgggctgccgcgtgctcttcggcctggacttcctgaccatgcacgccagcatcttcacg
ctgaccgtcatgagcagcgagcgctacgctgcggtgctgcggccgctggacaccgtgcag
cgccccaagggctaccgcaagctgctggcgctgggcacctggctgctggcgctgctgctg
acgctgcccgtgatgctggccatgcggctggtgcgccggggtcccaagagcctgtgcctg
cccgcctggggcccgcgcgcccaccgcgcctacctgacgctgctcttcgccaccagcatc
gcggggcccgggctgctcatcgggctgctctacgcgcgcctggcccgcgcctaccgccgc
tcgcagcgcgcctccttcaagcgggcccggcggccgggggcgcgcgcgctgcgcctggtg
ctgggcatcgtgctgctcttctgggcctgcttcctgcccttctggctgtggcagctgctc
gcccagtaccaccaggccccgctggcgccgcggacggcgcgcatcgtcaactacctgacc
acctgcctcacctacggcaacagctgcgccaaccccttcctctacacgctgctcaccagg
aactaccgcgaccacctgcgcggccgcgtgcggggcccgggcagcgggggaggccggggg
cccgttccctccctgcagccccgcgcccgcttccagcgctgttcgggccgctccctgtct
tcctgcagcccacagcccactgacagcctcgtgctggccccagcggccccggcccgacct
gcgcccgagggtcccagggccccggcgtga

Protein Sequence

>2837 : length: 389
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA



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