Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2977

Name

GUCY1A2

Synonym

GC-SA2|GUC1A2;guanylate cyclase 1, soluble, alpha 2;GUCY1A2;guanylate cyclase 1, soluble, alpha 2

Definition

GCS-alpha-2|guanylate cyclase soluble subunit alpha-2

Position

11q21-q22

Gene Type

protein-coding

PAH Type

Description

PH

Supplemental Table 1: A list of genes and functional categories that comprises a PHrelevant gene module (PH-module).
More detail of all Human literatures about GUCY1A2

Pathways and Diseases

Pathway

Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270

Pathway

ion channels and their functional role in vascular endothelium;PID BioCarta;100055

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Purine metabolism;KEGG PATHWAY;hsa00230

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

Salivary secretion;KEGG PATHWAY;hsa04970

Pathway

actions of nitric oxide in the heart;PID BioCarta;100094

External Links

Links to Entrez Gene

2977

Links to all GeneRIF Items

2977

Links to iHOP

2977

Sequence Information

Nucleotide Sequence

>2977 : length: 2199
atgtctcgaaggaagatttcgtccgagtccttcagctccctgggctccgactacctggag
accagcccggaggaggagggggagtgccccctgtctaggctctgctggaatggcagccgg
agcccgcccgggccgctggagcccagcccggccgcagctgccgctgccgccgccccggcc
ccgaccccggctgcttctgccgccgccgccgctgccactgccggggccaggagggtgcag
cgccggaggcgggtcaacctggactcgctgggcgagagcatcagccgcctgacggcgccc
tcgcctcagacgatacagcagactctcaagaggacactgcagtattatgaacatcaagtt
attggttacagggatgcagaaaagaatttccacaatatctctaacagatgctcctatgca
gaccactccaacaaagaagaaattgaagatgtctcaggaattcttcagtgtactgctaat
atactcggtttgaagtttgaggaaattcaaaaaagatttggtgaagagttctttaatata
tgctttcatgagaatgagagagtccttcgagctgtaggtggcactttgcaggactttttt
aacggctttgatgctttgttggaacacattagaacttcttttggaaaacaggccactctg
gagtcaccatctttcctatgcaaagagctccctgaaggtactctcatgctccactacttc
caccctcaccatattgtggggtttgcaatgctggggatgattaaggctgcaggaaagaag
atctatcggctggatgtggaagtggaacaggttgcaaatgagaagctatgctctgatgtt
tcaaacccaggcaattgtagctgtcttactttccttatcaaagaatgtgaaaatactaat
atcatgaagaaccttccacagggaacctcccaagttcctgcggacctcagaattagcatc
aacaccttctgtagagccttccctttccacttgatgtttgatcccagcatgtcagtcctt
cagttgggggaaggtctaaggaagcagcttcgatgtgacactcacaaagtgctcaagttt
gaggactgcttcgagattgtatctccaaaggttaatgccacctttgaaagggtcctgctg
cgactgtctaccccgtttgtgattagaaccaagcctgaggcttctggctctgaaaataaa
gacaaggtgatggaagtcaaaggacaaatgatccatgttccagaatcaaattccatttta
tttttgggctctccatgtgtggacaagttggatgaactcatgggccgagggctacatctc
tcagacatccctatccatgatgccacccgagatgtcattttggttggtgagcaggcaaag
gcccaagatgggttgaagaaaaggatggataaattaaaggcaactttagaaagaactcac
caggccctggaagaagagaaaaagaagacagtggatcttctatattctattttccctggt
gatgtagcccagcaattatggcaagggcagcaagtacaggccagaaagtttgatgatgtc
accatgctcttttcagacattgttggcttcacagccatatgtgcccagtgtactcccatg
caagtaatcagcatgctgaatgaactgtacaccagatttgaccaccagtgtggatttttg
gatatttataaggtggaaacaataggtgatgcctactgtgttgcagcagggctccacaga
aaaagcctctgccatgctaaacccattgctctgatggccttgaagatgatggaactttca
gaagaggtgctgacacctgatggaagaccgattcagatgaggataggaattcactcaggc
tccgtgctggctggagttgttggggtgcgaatgccacgttattgcctgtttggaaataat
gtcacactggcaagcaaattcgagtcgggaagtcaccctcggcgcatcaatgtcagccca
accacttaccaattattaaaacgagaagaaagtttcacattcattccgcggtctcgtgaa
gagcttccagacaactttccaaaggaaattcctgggatctgctatttcctggaggtaagg
actggtccaaagccaccaaagccttctctttcttcgtcgagaataaaaaaggtttcctac
aacatcggcaccatgttcctccgggagacaagcctctga

Protein Sequence

>2977 : length: 732
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA
PTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQV
IGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI
CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYF
HPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTN
IMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF
EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSIL
FLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH
QALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM
QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELS
EEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP
TTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSY
NIGTMFLRETSL



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