Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2982

Name

GUCY1A3

Synonym

GC-SA3|GUC1A3|GUCA3|GUCSA3|GUCY1A1;guanylate cyclase 1, soluble, alpha 3;GUCY1A3;guanylate cyclase 1, soluble, alpha 3

Definition

GC-S-alpha-1|GCS-alpha-1|GCS-alpha-3|guanylate cyclase soluble subunit alpha-3|soluble guanylate cyclase large subunit

Position

4q31.1-q31.2

Gene Type

protein-coding

PAH Type

Description

PAH

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

PH

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

PH

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

PH

Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR.
More detail of all Human literatures about GUCY1A3

Pathways and Diseases

Pathway

Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Purine metabolism;KEGG PATHWAY;hsa00230

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

Salivary secretion;KEGG PATHWAY;hsa04970

Pathway

actions of nitric oxide in the heart;PID BioCarta;100094

External Links

Links to Entrez Gene

2982

Links to all GeneRIF Items

2982

Links to iHOP

2982

Sequence Information

Nucleotide Sequence

>2982 : length: 2073
atgttctgcacgaagctcaaggatctcaagatcacaggagagtgtcctttctccttactg
gcaccaggtcaagttcctaacgagtcttcagaggaggcagcaggaagctcagagagctgc
aaagcaaccgtgcccatctgtcaagacattcctgagaagaacatacaagaaagtcttcct
caaagaaaaaccagtcggagccgagtctatcttcacactttggcagagagtatttgcaaa
ctgattttcccagagtttgaacggctgaatgttgcacttcagagaacattggcaaagcac
aaaataaaagaaagcaggaaatctttggaaagagaagactttgaaaaaacaattgcagag
caagcagttgcagcaggagttccagtggaggttatcaaagaatctcttggtgaagaggtt
tttaaaatatgttacgaggaagatgaaaacatccttggggtggttggaggcacccttaaa
gattttttaaacagcttcagtacccttctgaaacagagcagccattgccaagaagcagga
aaaaggggcaggcttgaggacgcctccattctatgcctggataaggaggatgattttcta
catgtttactacttcttccctaagagaaccacctccctgattcttcccggcatcataaag
gcagctgctcacgtattatatgaaacggaagtggaagtgtcgttaatgcctccctgcttc
cataatgattgcagcgagtttgtgaatcagccctacttgttgtactccgttcacatgaaa
agcaccaagccatccctgtcccccagcaaaccccagtcctcgctggtgattcccacatcg
ctattctgcaagacatttccattccatttcatgtttgacaaagatatgacaattctgcaa
tttggcaatggcatcagaaggctgatgaacaggagagactttcaaggaaagcctaatttt
gaagaatactttgaaattctgactccaaaaatcaaccagacgtttagcgggatcatgact
atgttgaatatgcagtttgttgtacgagtgaggagatgggacaactctgtgaaaaaatct
tcaagggttatggacctcaaaggccaaatgatctacattgttgaatccagtgcaatcttg
tttttggggtcaccctgtgtggacagattagaagattttacaggacgagggctctacctc
tcagacatcccaattcacaatgcactgagggatgtggtcttaataggggaacaagcccga
gctcaagatggcctgaagaagaggctggggaagctgaaggctacccttgagcaagcccac
caagccctggaggaggagaagaaaaagacagtagaccttctgtgctccatatttccctgt
gaggttgctcagcagctgtggcaagggcaagttgtgcaagccaagaagttcagtaatgtc
accatgctcttctcagacatcgttgggttcactgccatctgctcccagtgctcaccgctg
caggtcatcaccatgctcaatgcactgtacactcgcttcgaccagcagtgtggagagctg
gatgtctacaaggtggagaccattggcgatgcctattgtgtagctgggggattacacaaa
gagagtgatactcatgctgttcagatagcgctgatggccctgaagatgatggagctctct
gatgaagttatgtctccccatggagaacctatcaagatgcgaattggactgcactctgga
tcagtttttgctggcgtcgttggagttaaaatgccccgttactgtctttttggaaacaat
gtcactctggctaacaaatttgagtcctgcagtgtaccacgaaaaatcaatgtcagccca
acaacttacagattactcaaagactgtcctggtttcgtgtttacccctcgatcaagggag
gaacttccaccaaacttccctagtgaaatccccggaatctgccattttctggatgcttac
caacaaggaacaaactcaaaaccatgcttccaaaagaaagatgtggaagatggcaatgcc
aattttttaggcaaagcatcaggaatagattag

Protein Sequence

>2982 : length: 690
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID



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