| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2983 |
Name | GUCY1B3 |
Synonym | GC-S-beta-1|GC-SB3|GUC1B3|GUCB3|GUCSB3|GUCY1B1;guanylate cyclase 1, soluble, beta 3;GUCY1B3;guanylate cyclase 1, soluble, beta 3 |
Definition | GCS-beta-1|GCS-beta-3|guanylate cyclase soluble subunit beta-1|guanylate cyclase soluble subunit beta-3|soluble guanylate cyclase small subunit |
Position | 4q31.3-q33 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Upregulation of soluble guanylate cyclase in pulmonary arterial smooth muscle cells was noted in human idiopathic pulmonary arterial hypertension lungs and lungs from animal models of pulmonary arterial hypertension. Stimulation of soluble guanylate cyclase reversed right heart hypertrophy and structural lung vascular remodelling. Soluble guanylate cyclase may thus offer a new target for therapeutic intervention in pulmonary arterial hypertension. |
| More detail of all Human literatures about GUCY1B3 | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Purine metabolism;KEGG PATHWAY;hsa00230 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | actions of nitric oxide in the heart;PID BioCarta;100094 |
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External Links |
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Links to Entrez Gene | 2983 |
Links to all GeneRIF Items | 2983 |
Links to iHOP | 2983 |
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Sequence Information |
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Nucleotide Sequence |
>2983 : length: 1860 atgtacggatttgtgaatcacgccctggagttgctggtgatccgcaattacggccccgag gtgtgggaagacatcaaaaaagaggcacagttagatgaagaaggacagtttcttgtcaga ataatatatgatgactccaaaacttatgatttggttgctgctgcaagcaaagtcctcaat ctcaatgctggagaaatcctccaaatgtttgggaagatgtttttcgtcttttgccaagaa tctggttatgatacaatcttgcgtgtcctgggctctaatgtcagagaatttctacagaac cttgatgctctgcacgaccaccttgctaccatctacccaggaatgcgtgcaccttccttt aggtgcactgatgcagaaaagggcaaaggactcattttgcactactactcagagagagaa ggacttcaggatattgtcattggaatcatcaaaacagtggcacaacaaatccatggcact gaaatagacatgaaggttattcagcaaagaaatgaagaatgtgatcatactcaattttta attgaagaaaaagagtcaaaagaagaggatttttatgaagatcttgacagatttgaagaa aatggtacccaggaatcacgcatcagcccatatacattctgcaaagcttttccttttcat ataatatttgaccgggacctagtggtcactcagtgtggcaatgctatatacagagttctc ccccagctccagcctgggaattgcagccttctgtctgtcttctcgctggttcgtcctcat attgatattagtttccatgggatcctttctcacatcaatactgtttttgtattgagaagc aaggaaggattgttggatgtggagaaattagaatgtgaggatgaactgactgggactgag atcagctgcttacgtctcaagggtcaaatgatctacttacctgaagcagatagcatactt tttctatgttcaccaagtgtcatgaacctggacgatttgacaaggagagggctgtatcta agtgacatccctctgcatgatgccacgcgcgatcttgttcttttgggagaacaatttaga gaggaatacaaactcacccaagaactggaaatcctcactgacaggctacagctcacgtta agagccctggaagatgaaaagaaaaagacagacacattgctgtattctgtccttcctccg tctgttgccaatgagctgcggcacaagcgtccagtgcctgccaaaagatatgacaatgtg accatcctctttagtggcattgtgggcttcaatgctttctgtagcaagcatgcatctgga gaaggagccatgaagatcgtcaacctcctcaacgacctctacaccagatttgacacactg actgattcccggaaaaacccatttgtttataaggtggagactgttggtgacaagtatatg acagtgagtggtttaccagagccatgcattcaccatgcacgatccatctgccacctggcc ttggacatgatggaaattgctggccaggttcaagtagatggtgaatctgttcagataaca atagggatacacactggagaggtagttacaggtgtcataggacagcggatgcctcgatac tgtctttttgggaatactgtcaacctcacaagccgaacagaaaccacaggagaaaaggga aaaataaatgtgtctgaatatacatacagatgtcttatgtctccagaaaattcagatcca caattccacttggagcacagaggcccagtgtccatgaagggcaaaaaagaaccaatgcaa gtttggtttctatccagaaaaaatacaggaacagaggaaacaaagcaggatgatgactga |
Protein Sequence |
>2983 : length: 619 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ VWFLSRKNTGTEETKQDDD |