| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3091 |
Name | HIF1A |
Synonym | HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78;hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor);HIF1A;hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
Definition | ARNT interacting protein|ARNT-interacting protein|HIF-1-alpha|PAS domain-containing protein 8|basic-helix-loop-helix-PAS protein MOP1|class E basic helix-loop-helix protein 78|hypoxia-inducible factor 1 alpha isoform I.3|hypoxia-inducible factor 1, alpha |
Position | 14q23.2 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | "HIF-1alpha, procollagen-proline dioxygenases and OS-9 are all involved in the pathogenesis of hypoxic pulmonary hypertension in rats." |
HPH | Hypoxic pulmonary hypertension is closely associated with increased expression of HIF-1alpha and VEGF in high altitide areas. |
PAH | HIF-1alpha was found to be primarily expressed in neointimal lesion areas in a model of pulmonary arterial hypertension. |
PAH | HIF-1alpha was found to be primarily expressed in neointimal lesion areas in a model of pulmonary arterial hypertension. |
| More detail of all Rat literatures about HIF1A | |
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Pathways and Diseases |
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Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | hypoxia-inducible factor in the cardivascular system;PID BioCarta;100145 |
Pathway | vegf hypoxia and angiogenesis;PID BioCarta;100006 |
Pathway | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha;PID Curated;200122 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | mTOR signaling pathway;KEGG PATHWAY;hsa04150 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Disease | Ischemia;FunDO |
Disease | Vasculitis;FunDO |
Disease | Infection;FunDO |
Disease | cervical cancer endometrial cancer ovarian cancer;GAD |
Disease | kidney cancer;GAD |
Disease | Hyperglycemia;FunDO |
Disease | osteonecrosis;GAD |
Disease | Cancer;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
Disease | Metabolism disease;FunDO |
Disease | Barrett's esophagus;FunDO |
Disease | stroke, ischemic;GAD |
Disease | Dermatitis;FunDO |
Disease | VISION;GAD |
Disease | Aseptic necrosis of bone;FunDO |
Disease | oxygen consumption;GAD |
Disease | METABOLIC;GAD |
Disease | Stroke;FunDO |
Disease | retinopathy, diabetic;GAD |
Disease | colorectal cancer;GAD |
Disease | Drug abuse;FunDO |
Disease | diabetes, type 2;GAD |
Disease | esophageal cancer;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | Moyamoya disease;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Retinal disease;FunDO |
Disease | Pre-Eclampsia;FunDO |
Disease | Polycythemia;FunDO |
Disease | HIF-1alpha protein expression;GAD |
Disease | hypoxia;GAD |
Disease | CANCER;GAD |
Disease | Obesity;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 3091 |
Links to all GeneRIF Items | 3091 |
Links to iHOP | 3091 |
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Sequence Information |
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Nucleotide Sequence |
>3091 : length: 2481 atggagggcgccggcggcgcgaacgacaagaaaaagataagttctgaacgtcgaaaagaa aagtctcgagatgcagccagatctcggcgaagtaaagaatctgaagttttttatgagctt gctcatcagttgccacttccacataatgtgagttcgcatcttgataaggcctctgtgatg aggcttaccatcagctatttgcgtgtgaggaaacttctggatgctggtgatttggatatt gaagatgacatgaaagcacagatgaattgcttttatttgaaagccttggatggttttgtt atggttctcacagatgatggtgacatgatttacatttctgataatgtgaacaaatacatg ggattaactcagtttgaactaactggacacagtgtgtttgattttactcatccatgtgac catgaggaaatgagagaaatgcttacacacagaaatggccttgtgaaaaagggtaaagaa caaaacacacagcgaagcttttttctcagaatgaagtgtaccctaactagccgaggaaga actatgaacataaagtctgcaacatggaaggtattgcactgcacaggccacattcacgta tatgataccaacagtaaccaacctcagtgtgggtataagaaaccacctatgacctgcttg gtgctgatttgtgaacccattcctcacccatcaaatattgaaattcctttagatagcaag actttcctcagtcgacacagcctggatatgaaattttcttattgtgatgaaagaattacc gaattgatgggatatgagccagaagaacttttaggccgctcaatttatgaatattatcat gctttggactctgatcatctgaccaaaactcatcatgatatgtttactaaaggacaagtc accacaggacagtacaggatgcttgccaaaagaggtggatatgtctgggttgaaactcaa gcaactgtcatatataacaccaagaattctcaaccacagtgcattgtatgtgtgaattac gttgtgagtggtattattcagcacgacttgattttctcccttcaacaaacagaatgtgtc cttaaaccggttgaatcttcagatatgaaaatgactcagctattcaccaaagttgaatca gaagatacaagtagcctctttgacaaacttaagaaggaacctgatgctttaactttgctg gccccagccgctggagacacaatcatatctttagattttggcagcaacgacacagaaact gatgaccagcaacttgaggaagtaccattatataatgatgtaatgctcccctcacccaac gaaaaattacagaatataaatttggcaatgtctccattacccaccgctgaaacgccaaag ccacttcgaagtagtgctgaccctgcactcaatcaagaagttgcattaaaattagaacca aatccagagtcactggaactttcttttaccatgccccagattcaggatcagacacctagt ccttccgatggaagcactagacaaagttcacctgagcctaatagtcccagtgaatattgt ttttatgtggatagtgatatggtcaatgaattcaagttggaattggtagaaaaacttttt gctgaagacacagaagcaaagaacccattttctactcaggacacagatttagacttggag atgttagctccctatatcccaatggatgatgacttccagttacgttccttcgatcagttg tcaccattagaaagcagttccgcaagccctgaaagcgcaagtcctcaaagcacagttaca gtattccagcagactcaaatacaagaacctactgctaatgccaccactaccactgccacc actgatgaattaaaaacagtgacaaaagaccgtatggaagacattaaaatattgattgca tctccatctcctacccacatacataaagaaactactagtgccacatcatcaccatataga gatactcaaagtcggacagcctcaccaaacagagcaggaaaaggagtcatagaacagaca gaaaaatctcatccaagaagccctaacgtgttatctgtcgctttgagtcaaagaactaca gttcctgaggaagaactaaatccaaagatactagctttgcagaatgctcagagaaagcga aaaatggaacatgatggttcactttttcaagcagtaggaattggaacattattacagcag ccagacgatcatgcagctactacatcactttcttggaaacgtgtaaaaggatgcaaatct agtgaacagaatggaatggagcaaaagacaattattttaataccctctgatttagcatgt agactgctggggcaatcaatggatgaaagtggattaccacagctgaccagttatgattgt gaagttaatgctcctatacaaggcagcagaaacctactgcagggtgaagaattactcaga gctttggatcaagttaactga |
Protein Sequence |
>3091 : length: 826 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN |