| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3337 |
Name | DNAJB1 |
Synonym | HSPF1|Hdj1|Hsp40|RSPH16B|Sis1;DnaJ (Hsp40) homolog, subfamily B, member 1;DNAJB1;DnaJ (Hsp40) homolog, subfamily B, member 1 |
Definition | DnaJ (Hsp40) homolog, subfmaily B, member 1|dnaJ homolog subfamily B member 1|dnaJ protein homolog 1|hDj-1|heat shock 40 kDa protein 1|heat shock 40kD protein 1|heat shock protein 40|human DnaJ protein 1|radial spoke 16 homolog B |
Position | 19p13.2 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | "Several ER stress/UPR genes, including Immunoglobulin-heavy-chain binding protein (BiP), Activating Transcription Factor-4 and -6 (ATF4 and ATF6) and a spliced form of X-box binding protein (XBP1) were upregulated in lcSSc PBMCs, with the highest levels in patients with PAH. TG upregulated Heat shock proteins (HSP) and Interferon-regulated genes in control PBMCs. Selected HSP genes, particularly DNAJB1, and IFN-related genes were also found at significantly elevated levels in PBMCs from lcSSc patients, while IRF4 was significantly decreased. There was a positive correlation between DNAJB1 and severity of PAH disease (PAP) (r = 0.56, p<0.05) and between ER stress markers and IL-6 levels (r = 0.53, p< 0.0001) in lcSSc PBMCs." |
| More detail of all Human literatures about DNAJB1 | |
|
Pathways and Diseases |
|
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Disease | Schizophrenia;FunDO |
Disease | Herpes;FunDO |
Disease | Bipolar disorder;FunDO |
|
External Links |
|
Links to Entrez Gene | 3337 |
Links to all GeneRIF Items | 3337 |
Links to iHOP | 3337 |
|
Sequence Information |
|
Nucleotide Sequence |
>3337 : length: 1023 atgggtaaagactactaccagacgttgggcctggcccgcggcgcgtcggacgaggagatc aagcgggcctaccgccgccaggcgctgcgctaccacccggacaagaacaaggagcccggc gccgaggagaagttcaaggagatcgctgaggcctacgacgtgctcagcgacccgcgcaag cgcgagatcttcgaccgctacggggaggaaggcctaaaggggagtggccccagtggcggt agcggcggtggtgccaatggtacctctttcagctacacattccatggagaccctcatgcc atgtttgctgagttcttcggtggcagaaatccctttgacaccttttttgggcagcggaac ggggaggaaggcatggacattgatgacccattctctggcttccctatgggcatgggtggc ttcaccaacgtgaactttggccgctcccgctctgcccaagagcccgcccgaaagaagcaa gatcccccagtcacccacgaccttcgagtctcccttgaagagatctacagcggctgtacc aagaagatgaaaatctcccacaagcggctaaaccccgacggaaagagcattcgaaacgaa gacaaaatattgaccatcgaagtgaagaaggggtggaaagaaggaaccaaaatcactttc cccaaggaaggagaccagacctccaacaacattccagctgatatcgtctttgttttaaag gacaagccccacaatatctttaagagagatggctctgatgtcatttatcctgccaggatc agcctccgggaggctctgtgtggctgcacagtgaacgtccccactctggacggcaggacg atacccgtcgtattcaaagatgttatcaggcctggcatgcggcgaaaagttcctggagaa ggcctccccctccccaaaacacccgagaaacgtggggacctcattattgagtttgaagtg atcttccccgaaaggattccccagacatcaagaaccgtacttgagcaggttcttccaata tag |
Protein Sequence |
>3337 : length: 340 MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRK REIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRN GEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCT KKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLK DKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGE GLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI |