| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3351 |
Name | HTR1B |
Synonym | 5-HT1B|5-HT1DB|HTR1D2|HTR1DB|S12;5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled;HTR1B;5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled |
Definition | 5-HT-1B|5-HT-1D-beta|5-hydroxytryptamine receptor 1B|serotonin 1D beta receptor|serotonin receptor 1B |
Position | 6q13 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935. |
PAH | Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935. |
PH | These data show that activation of 5-HT(2B) receptors is a limiting step in the development of pulmonary hypertension. |
| More detail of all Mouse literatures about HTR1B | |
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Pathways and Diseases |
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Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080 |
Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026 |
Pathway | 5HT1 type receptor mediated signaling pathway;PANTHER;P04373 |
Disease | ADHD;GAD |
Disease | major depression;GAD |
Disease | obsessive-compulsive disorder;GAD |
Disease | schizoaffective disorder;GAD |
Disease | aggressive behavior;GAD |
Disease | Depression;FunDO |
Disease | migraine migraine with aura;GAD |
Disease | self-harm behavior;GAD |
Disease | METABOLIC;GAD |
Disease | alcoholism;GAD |
Disease | minimum lifetime body mass index;GAD |
Disease | Drug abuse;FunDO |
Disease | alcohol dependence;GAD |
Disease | PSYCH;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | attention-deficit hyperactivity disorder;GAD |
Disease | suicide;GAD |
Disease | attention deficit hyperactivity disorder;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | Bipolar disorder;FunDO |
Disease | Hypertension;FunDO |
Disease | body mass;GAD |
Disease | bipolar disorder;GAD |
Disease | Behavior disease;FunDO |
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External Links |
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Links to Entrez Gene | 3351 |
Links to all GeneRIF Items | 3351 |
Links to iHOP | 3351 |
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Sequence Information |
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Nucleotide Sequence |
>3351 : length: 1173 atggaggaaccgggtgctcagtgcgctccaccgccgcccgcgggctccgagacctgggtt cctcaagccaacttatcctctgctccctcccaaaactgcagcgccaaggactacatttac caggactccatctccctaccctggaaagtactgctggttatgctattggcgctcatcacc ttggccaccacgctctccaatgcctttgtgattgccacagtgtaccggacccggaaactg cacaccccggctaactacctgatcgcctctctggcggtcaccgacctgcttgtgtccatc ctggtgatgcccatcagcaccatgtacactgtcaccggccgctggacactgggccaggtg gtctgtgacttctggctgtcgtcggacatcacttgttgcactgcctccatcctgcacctc tgtgtcatcgccctggaccgctactgggccatcacggacgccgtggagtactcagctaaa aggactcccaagagggcggcggtcatgatcgcgctggtgtgggtcttctccatctctatc tcgctgccgcccttcttctggcgtcaggctaaggccgaagaggaggtgtcggaatgcgtg gtgaacaccgaccacatcctctacacggtctactccacggtgggtgctttctacttcccc accctgctcctcatcgccctctatggccgcatctacgtagaagcccgctcccggattttg aaacagacgcccaacaggaccggcaagcgcttgacccgagcccagctgataaccgactcc cccgggtccacgtcctcggtcacctctattaactcgcgggttcccgacgtgcccagcgaa tccggatctcctgtgtatgtgaaccaagtcaaagtgcgagtctccgacgccctgctggaa aagaagaaactcatggccgctagggagcgcaaagccaccaagaccctagggatcattttg ggagcctttattgtgtgttggctacccttcttcatcatctccctagtgatgcctatctgc aaagatgcctgctggttccacctagccatctttgacttcttcacatggctgggctatctc aactccctcatcaaccccataatctataccatgtccaatgaggactttaaacaagcattc cataaactgatacgttttaagtgcacaagttga |
Protein Sequence |
>3351 : length: 390 MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL NSLINPIIYTMSNEDFKQAFHKLIRFKCTS |