| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3357 |
Name | HTR2B |
Synonym | 5-HT(2B)|5-HT2B;5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled;HTR2B;5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled |
Definition | 5-HT 2B receptor|5-HT-2B|5-hydroxytryptamine 2B receptor|5-hydroxytryptamine receptor 2B|5-hydroxytryptamine receptor 2B variant b|serotonin receptor 2B |
Position | 2q36.3-q37.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Activation of 5-HT(2B) receptors on bone marrow lineage progenitors is critical for the development of pulmonary arterial hypertension. |
PAH | Activation of 5-HT(2B) receptors on bone marrow lineage progenitors is critical for the development of pulmonary arterial hypertension. |
PAH | Treatment with the PPARgamma agonist rosiglitazone in vivo reversed the expression and the vasocontractive effect of 5-HT2BR as well as the thickening of pulmonary arteries. |
| More detail of all Mouse literatures about HTR2B | |
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Pathways and Diseases |
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Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Disease | Drug abuse;FunDO |
Disease | Hypertension;FunDO |
Disease | Colon cancer;FunDO |
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External Links |
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Links to Entrez Gene | 3357 |
Links to all GeneRIF Items | 3357 |
Links to iHOP | 3357 |
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Sequence Information |
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Nucleotide Sequence |
>3357 : length: 1446 atggctctctcttacagagtgtctgaacttcaaagcacaattcctgagcacattttgcag agcacctttgttcacgttatctcttctaactggtctggattacagacagaatcaatacca gaggaaatgaaacagattgttgaggaacagggaaataaactgcactgggcagctcttctg atactcatggtgataatacccacaattggtggaaatacccttgttattctggctgtttca ctggagaagaagctgcagtatgctactaattactttctaatgtccttggcggtggctgat ttgctggttggattgtttgtgatgccaattgccctcttgacaataatgtttgaggctatg tggcccctcccacttgttctatgtcctgcctggttatttcttgacgttctcttttcaacc gcatccatcatgcatctctgtgccatttcagtggatcgttacatagccatcaaaaagcca atccaggccaatcaatataactcacgggctacagcattcatcaagattacagtggtgtgg ttaatttcaataggcattgccattccagtccctattaaagggatagagactgatgtggac aacccaaacaatatcacttgtgtgctgacaaaggaacgttttggcgatttcatgctcttt ggctcactggctgccttcttcacacctcttgcaattatgattgtcacctactttctcact atccatgctttacagaagaaggcttacttagtcaaaaacaagccacctcaacgcctaaca tggttgactgtgtctacagttttccaaagggatgaaacaccttgctcgtcaccggaaaag gtggcaatgctggatggttctcgaaaggacaaggctctgcccaactcaggtgatgaaaca cttatgcgaagaacatccacaattgggaaaaagtcagtgcagaccatttccaacgaacag agagcctcaaaggtcctagggattgtgtttttcctctttttgcttatgtggtgtcccttc tttattacaaatataactttagttttatgtgattcctgtaaccaaactactctccaaatg ctcctggagatatttgtgtggataggctatgtttcctcaggagtgaatcctttggtctac accctcttcaataagacatttcgggatgcatttggccgatatatcacctgcaattaccgg gccacaaagtcagtaaaaactctcagaaaacgctccagtaagatctacttccggaatcca atggcagagaactctaagtttttcaagaaacatggaattcgaaatgggattaaccctgcc atgtaccagagtccaatgaggctccgaagttcaaccattcagtcttcatcaatcattcta ctagatacgcttctcctcactgaaaatgaaggtgacaaaactgaagagcaagttagttat gtatag |
Protein Sequence |
>3357 : length: 481 MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY V |