| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3371 |
Name | TNC |
Synonym | 150-225|GMEM|GP|HXB|JI|TN|TN-C;tenascin C;TNC;tenascin C |
Definition | GP 150-225|cytotactin|glioma-associated-extracellular matrix antigen|hexabrachion (tenascin)|myotendinous antigen|neuronectin|tenascin|tenascin-C isoform 14/AD1/16 |
Position | 9q33 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension. |
PH | Defective pulmonary vascular remodeling in Smad8 mutant mice. |
| More detail of all Human literatures about TNC | |
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Pathways and Diseases |
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Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Disease | Embryoma;FunDO |
Disease | Tuberculosis;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Bronchopulmonary dysplasia;FunDO |
Disease | Vulvar disease;FunDO |
Disease | Nervous system tumor;FunDO |
Disease | Lung cancer;FunDO |
Disease | Respiratory failure;FunDO |
Disease | Asthma;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Oral cancer;FunDO |
Disease | Sarcoidosis;FunDO |
Disease | achilles tendon injuries;GAD |
Disease | Endometriosis;FunDO |
Disease | Colon cancer;FunDO |
Disease | Breast cancer;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
Disease | Chondrosarcoma;FunDO |
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External Links |
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Links to Entrez Gene | 3371 |
Links to all GeneRIF Items | 3371 |
Links to iHOP | 3371 |
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Sequence Information |
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Nucleotide Sequence |
>3371 : length: 6606 atgggggccatgactcagctgttggcaggtgtctttcttgctttccttgccctcgctacc gaaggtggggtcctcaagaaagtcatccggcacaagcgacagagtggggtgaacgccacc ctgccagaagagaaccagccagtggtgtttaaccacgtttacaacatcaagctgccagtg ggatcccagtgttcggtggatctggagtcagccagtggggagaaagacctggcaccgcct tcagagcccagcgaaagctttcaggagcacacagtggatggggaaaaccagattgtcttc acacatcgcatcaacatcccccgccgggcctgtggctgtgccgcagcccctgatgttaag gagctgctgagcagactggaggagctggagaacctggtgtcttccctgagggagcaatgt actgcaggagcaggctgctgtctccagcctgccacaggccgcttggacaccaggcccttc tgtagcggtcggggcaacttcagcactgaaggatgtggctgtgtctgcgaacctggctgg aaaggccccaactgctctgagcccgaatgtccaggcaactgtcaccttcgaggccggtgc attgatgggcagtgcatctgtgacgacggcttcacgggcgaggactgcagccagctggct tgccccagcgactgcaatgaccagggcaagtgcgtaaatggagtctgcatctgtttcgaa ggctacgccggggctgactgcagccgtgaaatctgcccagtgccctgcagtgaggagcac ggcacatgtgtagatggcttgtgtgtgtgccacgatggctttgcaggcgatgactgcaac aagcctctgtgtctcaacaattgctacaaccgtggacgatgcgtggagaatgagtgcgtg tgtgatgagggtttcacgggcgaagactgcagtgagctcatctgccccaatgactgcttc gaccggggccgctgcatcaatggcacctgctactgcgaagaaggcttcacaggtgaagac tgcgggaaacccacctgcccacatgcctgccacacccagggccggtgtgaggaggggcag tgtgtatgtgatgagggctttgccggtgtggactgcagcgagaagaggtgtcctgctgac tgtcacaatcgtggccgctgtgtagacgggcggtgtgagtgtgatgatggtttcactgga gctgactgtggggagctcaagtgtcccaatggctgcagtggccatggccgctgtgtcaat gggcagtgtgtgtgtgatgagggctatactggggaggactgcagccagctacggtgcccc aatgactgtcacagtcggggccgctgtgtcgagggcaaatgtgtatgtgagcaaggcttc aagggctatgactgcagtgacatgagctgccctaatgactgtcaccagcacggccgctgt gtgaatggcatgtgtgtttgtgatgacggctacacaggggaagactgccgggatcgccaa tgccccagggactgcagcaacaggggcctctgtgtggacggacagtgcgtctgtgaggac ggcttcaccggccctgactgtgcagaactctcctgtccaaatgactgccatggccagggt cgctgtgtgaatgggcagtgcgtgtgccatgaaggatttatgggcaaagactgcaaggag caaagatgtcccagtgactgtcatggccagggccgctgcgtggacggccagtgcatctgc cacgagggcttcacaggcctggactgtggccagcactcctgccccagtgactgcaacaac ttaggacaatgcgtctcgggccgctgcatctgcaacgagggctacagcggagaagactgc tcagaggtgtctcctcccaaagacctcgttgtgacagaagtgacggaagagacggtcaac ctggcctgggacaatgagatgcgggtcacagagtaccttgtcgtgtacacgcccacccac gagggtggtctggaaatgcagttccgtgtgcctggggaccagacgtccaccatcatccag gagctggagcctggtgtggagtactttatccgtgtatttgccatcctggagaacaagaag agcattcctgtcagcgccagggtggccacgtacttacctgcacctgaaggcctgaaattc aagtccatcaaggagacatctgtggaagtggagtgggatcctctagacattgcttttgaa acctgggagatcatcttccggaatatgaataaagaagatgagggagagatcaccaaaagc ctgaggaggccagagacctcttaccggcaaactggtctagctcctgggcaagagtatgag atatctctgcacatagtgaaaaacaatacccggggccctggcctgaagagggtgaccacc acacgcttggatgcccccagccagatcgaggtgaaagatgtcacagacaccactgccttg atcacctggttcaagcccctggctgagatcgatggcattgagctgacctacggcatcaaa gacgtgccaggagaccgtaccaccatcgatctcacagaggacgagaaccagtactccatc gggaacctgaagcctgacactgagtacgaggtgtccctcatctcccgcagaggtgacatg tcaagcaacccagccaaagagaccttcacaacaggcctcgatgctcccaggaatcttcga cgtgtttcccagacagataacagcatcaccctggaatggaggaatggcaaggcagctatt gacagttacagaattaagtatgcccccatctctggaggggaccacgctgaggttgatgtt ccaaagagccaacaagccacaaccaaaaccacactcacaggtctgaggccgggaactgaa tatgggattggagtttctgctgtgaaggaagacaaggagagcaatccagcgaccatcaac gcagccacagagttggacacgcccaaggaccttcaggtttctgaaactgcagagaccagc ctgaccctgctctggaagacaccgttggccaaatttgaccgctaccgcctcaattacagt ctccccacaggccagtgggtgggagtgcagcttccaagaaacaccacttcctatgtcctg agaggcctggaaccaggacaggagtacaatgtcctcctgacagccgagaaaggcagacac aagagcaagcccgcacgtgtgaaggcatccactgaacaagcccctgagctggaaaacctc accgtgactgaggttggctgggatggcctcagactcaactggaccgcagctgaccaggcc tatgagcactttatcattcaggtgcaggaggccaacaaggtggaggcagctcggaacctc accgtgcctggcagccttcgggctgtggacataccgggcctcaaggctgctacgccttat acagtctccatctatggggtgatccagggctatagaacaccagtgctctctgctgaggcc tccacaggggaaactcccaatttgggagaggtcgtggtggccgaggtgggctgggatgcc ctcaaactcaactggactgctccagaaggggcctatgagtactttttcattcaggtgcag gaggctgacacagtagaggcagcccagaacctcaccgtcccaggaggactgaggtccaca gacctgcctgggctcaaagcagccactcattataccatcaccatccgcggggtcactcag gacttcagcacaacccctctctctgttgaagtcttgacagaggaggttccagatatggga aacctcacagtgaccgaggttagctgggatgctctcagactgaactggaccacgccagat ggaacctatgaccagtttactattcaggtccaggaggctgaccaggtggaagaggctcac aatctcacggttcctggcagcctgcgttccatggaaatcccaggcctcagggctggcact ccttacacagtcaccctgcacggcgaggtcaggggccacagcactcgaccccttgctgta gaggtcgtcacagaggatctcccacagctgggagatttagccgtgtctgaggttggctgg gatggcctcagactcaactggaccgcagctgacaatgcctatgagcactttgtcattcag gtgcaggaggtcaacaaagtggaggcagcccagaacctcacgttgcctggcagcctcagg gctgtggacatcccgggcctcgaggctgccacgccttatagagtctccatctatggggtg atccggggctatagaacaccagtactctctgctgaggcctccacagccaaagaacctgaa attggaaacttaaatgtttctgacataactcccgagagcttcaatctctcctggatggct accgatgggatcttcgagacctttaccattgaaattattgattccaataggttgctggag actgtggaatataatatctctggtgctgaacgaactgcccatatctcagggctaccccct agtactgattttattgtctacctctctggacttgctcccagcatccggaccaaaaccatc agtgccacagccacgacagaggccctgccccttctggaaaacctaaccatttccgacatt aatccctacgggttcacagtttcctggatggcatcggagaatgcctttgacagctttcta gtaacggtggtggattctgggaagctgctggacccccaggaattcacactttcaggaacc cagaggaagctggagcttagaggcctcataactggcattggctatgaggttatggtctct ggcttcacccaagggcatcaaaccaagcccttgagggctgagattgttacagaagccgaa ccggaagttgacaaccttctggtttcagatgccaccccagacggtttccgtctgtcctgg acagctgatgaaggggtcttcgacaattttgttctcaaaatcagagataccaaaaagcag tctgagccactggaaataaccctacttgcccccgaacgtaccagggacataacaggtctc agagaggctactgaatacgaaattgaactctatggaataagcaaaggaaggcgatcccag acagtcagtgctatagcaacaacagccatgggctccccaaaggaagtcattttctcagac atcactgaaaattcggctactgtcagctggagggcacccacagcccaagtggagagcttc cggattacctatgtgcccattacaggaggtacaccctccatggtaactgtggacggaacc aagactcagaccaggctggtgaaactcatacctggcgtggagtaccttgtcagcatcatc gccatgaagggctttgaggaaagtgaacctgtctcagggtcattcaccacagctctggat ggcccatctggcctggtgacagccaacatcactgactcagaagccttggccaggtggcag ccagccattgccactgtggacagttatgtcatctcctacacaggcgagaaagtgccagaa attacacgcacggtgtccgggaacacagtggagtatgctctgaccgacctcgagcctgcc acggaatacacactgagaatctttgcagagaaagggccccagaagagctcaaccatcact gccaagttcacaacagacctcgattctccaagagacttgactgctactgaggttcagtcg gaaactgccctccttacctggcgacccccccgggcatcagtcaccggttacctgctggtc tatgaatcagtggatggcacagtcaaggaagtcattgtgggtccagataccacctcctac agcctggcagacctgagcccatccacccactacacagccaagatccaggcactcaatggg cccctgaggagcaatatgatccagaccatcttcaccacaattggactcctgtaccccttc cccaaggactgctcccaagcaatgctgaatggagacacgacctctggcctctacaccatt tatctgaatggtgataaggctgaggcgctggaagtcttctgtgacatgacctctgatggg ggtggatggattgtgttcctgagacgcaaaaacggacgcgagaacttctaccaaaactgg aaggcatatgctgctggatttggggaccgcagagaagaattctggcttgggctggacaac ctgaacaaaatcacagcccaggggcagtacgagctccgggtggacctgcgggaccatggg gagacagcctttgctgtctatgacaagttcagcgtgggagatgccaagactcgctacaag ctgaaggtggaggggtacagtgggacagcaggtgactccatggcctaccacaatggcaga tccttctccacctttgacaaggacacagattcagccatcaccaactgtgctctgtcctac aaaggggctttctggtacaggaactgtcaccgtgtcaacctgatggggagatatggggac aataaccacagtcagggcgttaactggttccactggaagggccacgaacactcaatccag tttgctgagatgaagctgagaccaagcaacttcagaaatcttgaaggcaggcgcaaacgg gcataa |
Protein Sequence |
>3371 : length: 2201 MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPV GSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVK ELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGW KGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFE GYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECV CDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQ CVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVN GQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRC VNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQG RCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNN LGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTH EGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKF KSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYE ISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIK DVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLR RVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTE YGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYS LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENL TVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPY TVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQ EADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMG NLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGT PYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQ VQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPE IGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPP STDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFL VTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAE PEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGL REATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESF RITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALD GPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPA TEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLV YESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPF PKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYK LKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGD NNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA |