| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3480 |
Name | IGF1R |
Synonym | CD221|IGFIR|IGFR|JTK13;insulin-like growth factor 1 receptor;IGF1R;insulin-like growth factor 1 receptor |
Definition | IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2 |
Position | 15q26.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | MiRNA-328 inhibited L-type calcium channel-alpha1C expression through a miRNA-328 binding site within the 3' untranslational region of L-type calcium channel-alpha1C. |
| More detail of all Human literatures about IGF1R | |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | regulation of bad phosphorylation;PID BioCarta;100233 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | the igf-1 receptor and longevity;PID BioCarta;100115 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation;PID BioCarta;100135 |
Disease | Height;NHGRI |
Disease | Cancers of the lung and pleura;KEGG DISEASE |
Disease | Cancers of soft tissues and bone;KEGG DISEASE |
Disease | Bacteremia;GAD |
Disease | Insulin-like growth factor I, resistance to;OMIM |
Disease | breast cancer;GAD |
Disease | Oral cancer;FunDO |
Disease | Depression;FunDO |
Disease | Graves' disease;FunDO |
Disease | Synovial sarcoma;KEGG DISEASE;H00050 |
Disease | NEUROLOGICAL;GAD |
Disease | INFECTION;GAD |
Disease | Malignant pleural mesothelioma;KEGG DISEASE;H00015 |
Disease | Retinal disease;FunDO |
Disease | premature pubarche;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | blood pressure, arterial;GAD |
Disease | Sickle cell disease;FunDO |
Disease | Birth Weight;GAD |
Disease | Cancer;FunDO |
Disease | REPRODUCTION;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | Osteoporosis;FunDO |
Disease | Alzheimer's disease dementia;GAD |
Disease | Infertility;FunDO |
Disease | Septicemia;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 3480 |
Links to all GeneRIF Items | 3480 |
Links to iHOP | 3480 |
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Sequence Information |
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Nucleotide Sequence |
>3480 : length: 4104 atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcctgtttctctcc gccgcgctctcgctctggccgacgagtggagaaatctgcgggccaggcatcgacatccgc aacgactatcagcagctgaagcgcctggagaactgcacggtgatcgagggctacctccac atcctgctcatctccaaggccgaggactaccgcagctaccgcttccccaagctcacggtc attaccgagtacttgctgctgttccgagtggctggcctcgagagcctcggagacctcttc cccaacctcacggtcatccgcggctggaaactcttctacaactacgccctggtcatcttc gagatgaccaatctcaaggatattgggctttacaacctgaggaacattactcggggggcc atcaggattgagaaaaatgctgacctctgttacctctccactgtggactggtccctgatc ctggatgcggtgtccaataactacattgtggggaataagcccccaaaggaatgtggggac ctgtgtccagggaccatggaggagaagccgatgtgtgagaagaccaccatcaacaatgag tacaactaccgctgctggaccacaaaccgctgccagaaaatgtgcccaagcacgtgtggg aagcgggcgtgcaccgagaacaatgagtgctgccaccccgagtgcctgggcagctgcagc gcgcctgacaacgacacggcctgtgtagcttgccgccactactactatgccggtgtctgt gtgcctgcctgcccgcccaacacctacaggtttgagggctggcgctgtgtggaccgtgac ttctgcgccaacatcctcagcgccgagagcagcgactccgaggggtttgtgatccacgac ggcgagtgcatgcaggagtgcccctcgggcttcatccgcaacggcagccagagcatgtac tgcatcccttgtgaaggtccttgcccgaaggtctgtgaggaagaaaagaaaacaaagacc attgattctgttacttctgctcagatgctccaaggatgcaccatcttcaagggcaatttg ctcattaacatccgacgggggaataacattgcttcagagctggagaacttcatggggctc atcgaggtggtgacgggctacgtgaagatccgccattctcatgccttggtctccttgtcc ttcctaaaaaaccttcgcctcatcctaggagaggagcagctagaagggaattactccttc tacgtcctcgacaaccagaacttgcagcaactgtgggactgggaccaccgcaacctgacc atcaaagcagggaaaatgtactttgctttcaatcccaaattatgtgtttccgaaatttac cgcatggaggaagtgacggggactaaagggcgccaaagcaaaggggacataaacaccagg aacaacggggagagagcctcctgtgaaagtgacgtcctgcatttcacctccaccaccacg tcgaagaatcgcatcatcataacctggcaccggtaccggccccctgactacagggatctc atcagcttcaccgtttactacaaggaagcaccctttaagaatgtcacagagtatgatggg caggatgcctgcggctccaacagctggaacatggtggacgtggacctcccgcccaacaag gacgtggagcccggcatcttactacatgggctgaagccctggactcagtacgccgtttac gtcaaggctgtgaccctcaccatggtggagaacgaccatatccgtggggccaagagtgag atcttgtacattcgcaccaatgcttcagttccttccattcccttggacgttctttcagca tcgaactcctcttctcagttaatcgtgaagtggaaccctccctctctgcccaacggcaac ctgagttactacattgtgcgctggcagcggcagcctcaggacggctacctttaccggcac aattactgctccaaagacaaaatccccatcaggaagtatgccgacggcaccatcgacatt gaggaggtcacagagaaccccaagactgaggtgtgtggtggggagaaagggccttgctgc gcctgccccaaaactgaagccgagaagcaggccgagaaggaggaggctgaataccgcaaa gtctttgagaatttcctgcacaactccatcttcgtgcccagacctgaaaggaagcggaga gatgtcatgcaagtggccaacaccaccatgtccagccgaagcaggaacaccacggccgca gacacctacaacatcaccgacccggaagagctggagacagagtaccctttctttgagagc agagtggataacaaggagagaactgtcatttctaaccttcggcctttcacattgtaccgc atcgatatccacagctgcaaccacgaggctgagaagctgggctgcagcgcctccaacttc gtctttgcaaggactatgcccgcagaaggagcagatgacattcctgggccagtgacctgg gagccaaggcctgaaaactccatctttttaaagtggccggaacctgagaatcccaatgga ttgattctaatgtatgaaataaaatacggatcacaagttgaggatcagcgagaatgtgtg tccagacaggaatacaggaagtatggaggggccaagctaaaccggctaaacccggggaac tacacagcccggattcaggccacatctctctctgggaatgggtcgtggacagatcctgtg ttcttctatgtccaggccaaaacaggatatgaaaacttcatccatctgatcatcgctctg cccgtcgctgtcctgttgatcgtgggagggttggtgattatgctgtacgtcttccataga aagagaaataacagcaggctggggaatggagtgctgtatgcctctgtgaacccggagtac ttcagcgctgctgatgtgtacgttcctgatgagtgggaggtggctcgggagaagatcacc atgagccgggaacttgggcaggggtcgtttgggatggtctatgaaggagttgccaagggt gtggtgaaagatgaacctgaaaccagagtggccattaaaacagtgaacgaggccgcaagc atgcgtgagaggattgagtttctcaacgaagcttctgtgatgaaggagttcaattgtcac catgtggtgcgattgctgggtgtggtgtcccaaggccagccaacactggtcatcatggaa ctgatgacacggggcgatctcaaaagttatctccggtctctgaggccagaaatggagaat aatccagtcctagcacctccaagcctgagcaagatgattcagatggccggagagattgca gacggcatggcatacctcaacgccaataagttcgtccacagagaccttgctgcccggaat tgcatggtagccgaagatttcacagtcaaaatcggagattttggtatgacgcgagatatc tatgagacagactattaccggaaaggagggaaagggctgctgcccgtgcgctggatgtct cctgagtccctcaaggatggagtcttcaccacttactcggacgtctggtccttcggggtc gtcctctgggagatcgccacactggccgagcagccctaccagggcttgtccaacgagcaa gtccttcgcttcgtcatggagggcggccttctggacaagccagacaactgtcctgacatg ctgtttgaactgatgcgcatgtgctggcagtataaccccaagatgaggccttccttcctg gagatcatcagcagcatcaaagaggagatggagcctggcttccgggaggtctccttctac tacagcgaggagaacaagctgcccgagccggaggagctggacctggagccagagaacatg gagagcgtccccctggacccctcggcctcctcgtcctccctgccactgcccgacagacac tcaggacacaaggccgagaacggccccggccctggggtgctggtcctccgcgccagcttc gacgagagacagccttacgcccacatgaacgggggccgcaagaacgagcgggccttgccg ctgccccagtcttcgacctgctga |
Protein Sequence |
>3480 : length: 1367 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC |