| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3662 |
Name | IRF4 |
Synonym | LSIRF|MUM1|NF-EM5;interferon regulatory factor 4;IRF4;interferon regulatory factor 4 |
Definition | lymphocyte-specific interferon regulatory factor|multiple myeloma oncogene 1 |
Position | 6p25-p23 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "RESULTS: Several ER stress/UPR genes, including Immunoglobulin-heavy-chain binding protein (BiP), Activating Transcription Factor-4 and -6 (ATF4 and ATF6) and a spliced form of X-box binding protein (XBP1) were upregulated in lcSSc PBMCs, with the highest levels in patients with PAH". |
| More detail of all Human literatures about IRF4 | |
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Pathways and Diseases |
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Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Disease | Eye color;NHGRI |
Disease | IMMUNE;GAD |
Disease | Bone marrow disease;FunDO |
Disease | Celiac disease;NHGRI |
Disease | Hair color;NHGRI |
Disease | Freckling;NHGRI |
Disease | HIV;GAD |
Disease | Multiple myeloma;OMIM |
Disease | Celiac Disease;GAD |
Disease | Melanoma;FunDO |
Disease | Chronic lymphocytic leukemia;GAD |
Disease | Black vs blond hair color;GAD |
Disease | Black vs. red hair color;NHGRI |
Disease | Leukemia;FunDO |
Disease | CANCER;GAD |
Disease | freckles;GAD |
Disease | INFECTION;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | Black vs red hair color;GAD |
Disease | Black vs. blond hair color;NHGRI |
Disease | Chronic lymphocytic leukemia;NHGRI |
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External Links |
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Links to Entrez Gene | 3662 |
Links to all GeneRIF Items | 3662 |
Links to iHOP | 3662 |
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Sequence Information |
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Nucleotide Sequence |
>3662 : length: 1353 atgaacctggagggcggcggccgaggcggagagttcggcatgagcgcggtgagctgcggc aacgggaagctccgccagtggctgatcgaccagatcgacagcggcaagtaccccgggctg gtgtgggagaacgaggagaagagcatcttccgcatcccctggaagcacgcgggcaagcag gactacaaccgcgaggaggacgccgcgctcttcaaggcttgggcactgtttaaaggaaag ttccgagaaggcatcgacaagccggaccctcccacctggaagacgcgcctgcggtgcgct ttgaacaagagcaatgactttgaggaactggttgagcggagccagctggacatctcagac ccgtacaaagtgtacaggattgttcctgagggagccaaaaaaggagccaagcagctcacc ctggaggacccgcagatgtccatgagccacccctacaccatgacaacgccttacccttcg ctcccagcccaggttcacaactacatgatgccacccctcgaccgaagctggagggactac gtcccggatcagccacacccggaaatcccgtaccaatgtcccatgacgtttggaccccgc ggccaccactggcaaggcccagcttgtgaaaatggttgccaggtgacaggaaccttttat gcttgtgccccacctgagtcccaggctcccggagtccccacagagccaagcataaggtct gccgaagccttggcgttctcagactgccggctgcacatctgcctgtactaccgggaaatc ctcgtgaaggagctgaccacgtccagccccgagggctgccggatctcccatggacatacg tatgacgccagcaacctggaccaggtcctgttcccctacccagaggacaatggccagagg aaaaacattgagaagctgctgagccacctggagaggggcgtggtcctctggatggccccc gacgggctctatgcgaaaagactgtgccagagcaggatctactgggacgggcccctggcg ctgtgcaacgaccggcccaacaaactggagagagaccagacctgcaagctctttgacaca cagcagttcttgtcagagctgcaagcgtttgctcaccacggccgctccctgccaagattc caggtgactctatgctttggagaggagtttccagaccctcagaggcaaagaaagctcatc acagctcacgtagaacctctgctagccagacaactatattattttgctcaacaaaacagt ggacatttcctgaggggctacgatttaccagaacacatcagcaatccagaagattaccac agatctatccgccattcctctattcaagaatga |
Protein Sequence |
>3662 : length: 450 MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQVHNYMMPPLDRSWRDY VPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRS AEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQR KNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDT QQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNS GHFLRGYDLPEHISNPEDYHRSIRHSSIQE |