| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3741 |
Name | KCNA5 |
Synonym | ATFB7|HCK1|HK2|HPCN1|KV1.5|PCN1;potassium voltage-gated channel, shaker-related subfamily, member 5;KCNA5;potassium voltage-gated channel, shaker-related subfamily, member 5 |
Definition | cardiac potassium channel|insulinoma and islet potassium channel|potassium channel 1|potassium voltage-gated channel subfamily A member 5|voltage-gated potassium channel HK2|voltage-gated potassium channel protein Kv1.5|voltage-gated potassium channel sub |
Position | 12p13 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Overexpression of human KCNA5 increases IK V and enhances apoptosis. |
PAH | Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. |
PAH | "Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer." |
PAH | Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. |
PAH | Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population. |
PH | Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. |
PH | The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. |
| More detail of all Human literatures about KCNA5 | |
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External Links |
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Links to Entrez Gene | 3741 |
Links to all GeneRIF Items | 3741 |
Links to iHOP | 3741 |
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Sequence Information |
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Nucleotide Sequence |
>3741 : length: 1842 atggagatcgccctggtgcccctggagaacggcggtgccatgaccgtcagaggaggcgat gaggcccgggcaggctgcggccaggccacagggggagagctccagtgtcccccgacggct gggctcagcgatgggcccaaggagccggcgccaaaggggcgcggcgcgcagagagacgcg gactcgggagtgcggcccttgcctccgctgccggacccgggagtgcggcccttgcctccg ctgccagaggagctgccacggcctcgacggccgcctcccgaggacgaggaggaagaaggc gatcccggcctgggcacggtggaggaccaggctctgggcacggcgtccctgcaccaccag cgcgtccacatcaacatctccgggctgcgctttgagacgcagctgggcaccctggcgcag ttccccaacacactcctgggggaccccgccaagcgcctgcgctacttcgaccccctgagg aacgagtacttcttcgaccgcaaccggcccagcttcgacggtatcctctactactaccag tccgggggccgcctgcggaggccggtcaacgtctccctggacgtgttcgcggacgagata cgcttctaccagctgggggacgaggccatggagcgcttccgcgaggatgagggcttcatt aaagaagaggagaagcccctgccccgcaacgagttccagcgccaggtgtggcttatcttc gagtatccggagagctctgggtccgcgcgggccatcgccatcgtctcggtcttggttatc ctcatctccatcatcaccttctgcttggagaccctgcctgagttcagggatgaacgtgag ctgctccgccaccctccggcgccccaccagcctcccgcgcccgcccctggggccaacggc agcggggtcatggccccgccctctggccctacggtggcaccgctcctgcccaggaccctg gccgaccccttcttcatcgtggagaccacgtgcgtcatctggttcaccttcgagctgctc gtgcgcttcttcgcctgccccagcaaggcagggttctcccggaacatcatgaacatcatc gatgtggtggccatcttcccctacttcatcaccctgggcaccgaactggcagagcagcag ccagggggtggaggaggcggccagaatgggcagcaggccatgtccctggccatcctccga gtcatccgcctggtccgggtgttccgcatcttcaagctctcccgccactccaaggggctg cagatcctgggcaagaccttgcaggcctccatgagggagctggggctgctcatcttcttc ctcttcatcggggtcatcctcttctccagtgccgtctacttcgcagaggctgacaaccag ggaacccatttctctagcatccctgacgccttctggtgggcagtggtcaccatgaccact gtgggctacggggacatgaggcccatcactgttgggggcaagatcgtgggctcgctgtgt gccatcgccggggtcctcaccattgccctgcctgtgcccgtcatcgtctccaacttcaac tacttctaccaccgggaaacggatcacgaggagccggcagtccttaaggaagagcagggc actcagagccaggggccggggctggacagaggagtccagcggaaggtcagcgggagcagg ggatccttctgcaaggctggggggaccctggagaatgcagacagtgcccgaaggggcagc tgccccctagagaagtgtaacgtcaaggccaagagcaacgtggacttgcggaggtccctt tatgccctctgcctggacaccagccgggaaacagatttgtga |
Protein Sequence |
>3741 : length: 613 MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL YALCLDTSRETDL |