| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 384 |
Name | ARG2 |
Synonym | -;arginase, type II;ARG2;arginase, type II |
Definition | L-arginine amidinohydrolase|L-arginine ureahydrolase|arginase 2|arginase-2, mitochondrial|kidney arginase|kidney-type arginase|non-hepatic arginase|nonhepatic arginase|type II arginase |
Position | 14q24.1 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. |
PH | IL-13 contributes to the development of pulmonary hypertension via an IL-13receptor alpha2-arginase 2-dependent pathway. |
| More detail of all Human literatures about ARG2 | |
|
Pathways and Diseases |
|
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | superpathway of citrulline metabolism;BioCyc;PWY-5004 |
Pathway | Arginine and proline metabolism;KEGG PATHWAY;hsa00330 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Metabolism of amino acids and derivatives;Reactome;REACT:13 |
Pathway | arginine degradation I (arginase pathway);BioCyc;ARGASEDEG-PWY |
Pathway | urea cycle;BioCyc;PWY-4984 |
Pathway | citrulline biosynthesis;BioCyc;CITRULBIO-PWY |
Pathway | arginine degradation VI (arginase 2 pathway);BioCyc;ARG-PRO-PWY |
Disease | Sickle cell disease;FunDO |
Disease | Lung cancer;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
Disease | Prostate cancer;FunDO |
|
External Links |
|
Links to Entrez Gene | 384 |
Links to all GeneRIF Items | 384 |
Links to iHOP | 384 |
|
Sequence Information |
|
Nucleotide Sequence |
>384 : length: 1065 atgtccctaaggggcagcctctcgcgtctcctccagacgcgagtgcattccatcctgaag aaatccgtccactccgtggctgtgataggagccccgttctcacaagggcagaaaagaaaa ggagtggagcatggtcccgctgccataagagaagctggcttgatgaaaaggctctccagt ttgggctgccacctaaaagactttggagatttgagttttactccagtccccaaagatgat ctctacaacaacctgatagtgaatccacgctcagtgggtcttgccaaccaggaactggct gaggtggttagcagagctgtgtcagatggctacagctgtgtcacactgggaggagaccac agcctggcaatcggtaccattagtggccatgcccgacactgcccagacctttgtgttgtc tgggttgatgcccatgctgacatcaacacaccccttaccacttcatcaggaaatctccat ggacagccagtttcatttctcctcagagaactacaggataaggtaccacaactcccagga ttttcctggatcaaaccttgtatctcttctgcaagtattgtgtatattggtctgagagac gtggaccctcctgaacattttattttaaagaactatgatatccagtatttttccatgaga gatattgatcgacttggtatccagaaggtcatggaacgaacatttgatctgctgattggc aagagacaaagaccaatccatttgagttttgatattgatgcatttgaccctacactggct ccagccacaggaactcctgttgtcgggggactaacctatcgagaaggcatgtatattgct gaggaaatacacaatacagggttgctatcagcactggatcttgttgaagtcaatcctcag ttggccacctcagaggaagaggcgaagactacagctaacctggcagtagatgtgattgct tcaagctttggtcagacaagagaaggagggcatattgtctatgaccaacttcctactccc agttcaccagatgaatcagaaaatcaagcacgtgtgagaatttag |
Protein Sequence |
>384 : length: 354 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI |