| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4842 |
Name | NOS1 |
Synonym | IHPS1|N-NOS|NC-NOS|NOS|bNOS|nNOS;nitric oxide synthase 1 (neuronal);NOS1;nitric oxide synthase 1 (neuronal) |
Definition | NOS type I|constitutive NOS|neuronal NOS|nitric oxide synthase, brain|peptidyl-cysteine S-nitrosylase NOS1 |
Position | 12q24.2-q24.31 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | "Both bosentan and tezosentan reduced ET-1 and cytokine plasma levels and tissue expression, and inducible NOS and COX-2 RV activities". |
PH | Supplemental Table 1: A list of genes and functional categories that comprises a PHrelevant gene module (PH-module). |
| More detail of all Human literatures about NOS1 | |
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Pathways and Diseases |
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Pathway | sumoylation as a mechanism to modulate ctbp-dependent gene responses;PID BioCarta;100195 |
Pathway | superpathway of citrulline metabolism;BioCyc;PWY-5004 |
Pathway | nitric oxide signaling pathway;PID BioCarta;100092 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Arginine and proline metabolism;KEGG PATHWAY;hsa00330 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | citrulline-nitric oxide cycle;BioCyc;PWY-4983 |
Disease | atopy;GAD |
Disease | Parkinson's disease;GAD |
Disease | Alzheimer's disease;GAD |
Disease | Pyloric stenosis, infantile hypertrophic 1;OMIM |
Disease | infantile hypertrophic pyloric stenosis.;GAD |
Disease | IMMUNE;GAD |
Disease | sickle cell disease;GAD |
Disease | Asthma;GAD |
Disease | tIgE;GAD |
Disease | PSYCH;GAD |
Disease | asthma IgE;GAD |
Disease | cystic fibrosis;GAD |
Disease | suicide;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | cognitive trait;GAD |
Disease | nitric oxide, exhaled;GAD |
Disease | schizophrenia;GAD |
Disease | nitric oxide;GAD |
Disease | bipolar disorder;GAD |
Disease | slow transit constipation;GAD |
Disease | neuronal NO synthase (NOS1) gene polymorphism;GAD |
Disease | EO;GAD |
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External Links |
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Links to Entrez Gene | 4842 |
Links to all GeneRIF Items | 4842 |
Links to iHOP | 4842 |
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Sequence Information |
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Nucleotide Sequence |
>4842 : length: 4305 atggaggatcacatgttcggtgttcagcaaatccagcccaatgtcatttctgttcgtctc ttcaagcgcaaagttgggggcctgggatttctggtgaaggagcgggtcagtaagccgccc gtgatcatctctgacctgattcgtgggggcgccgcagagcagagtggcctcatccaggcc ggagacatcattcttgcggtcaacggccggcccttggtggacctgagctatgacagcgcc ctggaggtactcagaggcattgcctctgagacccacgtggtcctcattctgaggggccct gaaggtttcaccacgcacctggagaccacctttacaggtgatgggacccccaagaccatc cgggtgacacagcccctgggtccccccaccaaagccgtggatctgtcccaccagccaccg gccggcaaagaacagcccctggcagtggatggggcctcgggtcccgggaatgggcctcag catgcctacgatgatgggcaggaggctggctcactcccccatgccaacggcctggccccc aggcccccaggccaggaccccgcgaagaaagcaaccagagtcagcctccaaggcagaggg gagaacaatgaactgctcaaggagatagagcctgtgctgagccttctcaccagtgggagc agaggggtcaagggaggggcacctgccaaggcagagatgaaagatatgggaatccaggtg gacagagatttggacggcaagtcacacaaacctctgcccctcggcgtggagaacgaccga gtcttcaatgacctatgggggaagggcaatgtgcctgtcgtcctcaacaacccatattca gagaaggagcagccccccacctcaggaaaacagtcccccacaaagaatggcagcccctcc aagtgtccacgcttcctcaaggtcaagaactgggagactgaggtggttctcactgacacc ctccaccttaagagcacattggaaacgggatgcactgagtacatctgcatgggctccatc atgcatccttctcagcatgcaaggaggcctgaagacgtccgcacaaaaggacagctcttc cctctcgccaaagagtttattgatcaatactattcatcaattaaaagatttggctccaaa gcccacatggaaaggctggaagaggtgaacaaagagatcgacaccactagcacttaccag ctcaaggacacagagctcatctatggggccaagcacgcctggcggaatgcctcgcgctgt gtgggcaggatccagtggtccaagctgcaggtattcgatgcccgtgactgcaccacggcc cacgggatgttcaactacatctgtaaccatgtcaagtatgccaccaacaaagggaacctc aggtctgccatcaccatattcccccagaggacagacggcaagcacgacttccgagtctgg aactcccagctcatccgctacgctggctacaagcagcctgacggctccaccctgggggac ccagccaatgtgcagttcacagagatatgcatacagcagggctggaaaccgcctagaggc cgcttcgatgtcctgccgctcctgcttcaggccaacggcaatgaccctgagctcttccag attcctccagagctggtgttggaagttcccatcaggcaccccaagtttgagtggttcaag gacctggggctgaagtggtacggcctccccgccgtgtccaacatgctcctagagattggc ggcctggagttcagcgcctgtcccttcagtggctggtacatgggcacagagattggtgtc cgcgactactgtgacaactcccgctacaatatcctggaggaagtggccaagaagatgaac ttagacatgaggaagacgtcctccctgtggaaggaccaggcgctggtggagatcaatatc gcggttctctatagcttccagagtgacaaagtgaccattgttgaccatcactccgccacc gagtccttcattaagcacatggagaatgagtaccgctgccgggggggctgccctgccgac tgggtgtggatcgtgccccccatgtccggaagcatcacccctgtgttccaccaggagatg ctcaactaccggctcaccccctccttcgaataccagcctgatccctggaacacgcatgtc tggaaaggcaccaacgggacccccacaaagcggcgagccattggcttcaagaagctagca gaagctgtcaagttctcggccaagctgatggggcaggctatggccaagagggtgaaagcg accatcctctatgccacagagacaggcaaatcgcaagcttatgccaagaccttgtgtgag atcttcaaacacgcctttgatgccaaggtgatgtccatggaagaatatgacattgtgcac ctggaacatgaaactctggtccttgtggtcaccagcacctttggcaatggagatccccct gagaatggggagaaattcggctgtgctttgatggaaatgaggcaccccaactctgtgcag gaagaaaggaagagctacaaggtccgattcaacagcgtctcctcctactctgactcccaa aaatcatcaggcgatgggcccgacctcagagacaactttgagagtgctggacccctggcc aatgtgaggttctcagtttttggcctcggctcacgagcataccctcacttttgcgccttc ggacacgctgtggacaccctcctggaagaactgggaggggagaggatcctgaagatgagg gaaggggatgagctctgtgggcaggaagaggctttcaggacctgggccaagaaggtcttc aaggcagcctgtgatgtcttctgtgtgggagatgatgtcaacattgaaaaggccaacaat tccctcatcagcaatgatcgcagctggaagagaaacaagttccgcctcacctttgtggcc gaagctccagaactcacacaaggtctatccaatgtccacaaaaagcgagtctcagctgcc cggctccttagccgtcaaaacctccagagccctaaatccagtcggtcaactatcttcgtg cgtctccacaccaacgggagccaggagctgcagtaccagcctggggaccacctgggtgtc ttccctggcaaccacgaggacctcgtgaatgccctgatcgagcggctggaggacgcgccg cctgtcaaccagatggtgaaagtggaactgctggaggagcggaacacggctttaggtgtc atcagtaactggacagacgagctccgcctcccgccctgcaccatcttccaggccttcaag tactacctggacatcaccacgccaccaacgcctctgcagctgcagcagtttgcctcccta gctaccagcgagaaggagaagcagcgtctgctggtcctcagcaagggtttgcaggagtac gaggaatggaaatggggcaagaaccccaccatcgtggaggtgctggaggagttcccatct atccagatgccggccaccctgctcctgacccagctgtccctgctgcagccccgctactat tccatcagctcctccccagacatgtaccctgatgaagtgcacctcactgtggccatcgtt tcctaccgcactcgagatggagaaggaccaattcaccacggcgtatgctcctcctggctc aaccggatacaggctgacgaactggtcccctgtttcgtgagaggagcacccagcttccac ctgccccggaacccccaagtcccctgcatcctcgttggaccaggcaccggcattgcccct ttccgaagcttctggcaacagcggcaatttgatatccaacacaaaggaatgaacccctgc cccatggtcctggtcttcgggtgccggcaatccaagatagatcatatctacagggaagag accctgcaggccaagaacaagggggtcttcagagagctgtacacggcttactcccgggag ccagacaaaccaaagaagtacgtgcaggacatcctgcaggagcagctggcggagtctgtg taccgagccctgaaggagcaagggggccacatatacgtctgtggggacgtcaccatggct gctgatgtcctcaaagccatccagcgcatcatgacccagcaggggaagctctcggcagag gacgccggcgtattcatcagccggatgagggatgacaaccgataccatgaggatattttt ggagtcaccctgcgaacgtacgaagtgaccaaccgccttagatctgagtccattgccttc attgaagagagcaaaaaagacaccgatgaggttttcagctcctaa |
Protein Sequence |
>4842 : length: 1434 MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS |