| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5136 |
Name | PDE1A |
Synonym | CAM-PDE-1A|HCAM-1|HCAM1|HSPDE1A;phosphodiesterase 1A, calmodulin-dependent;PDE1A;phosphodiesterase 1A, calmodulin-dependent |
Definition | 61 kDa Cam-PDE|calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A|calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase|cam-PDE 1A |
Position | 2q32.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "In chronically hypoxic mouse lungs and lungs from monocrotaline-injected rats, PDE1A upregulation was detected in the structurally remodeled arterial muscular layer. Long-term infusion of the PDE1 inhibitor 8-methoxymethyl 3-isobutyl-1-methylxanthine in hypoxic mice and monocrotaline-injected rats with fully established pulmonary hypertension reversed the pulmonary artery pressure elevation, structural remodeling of the lung vasculature (nonmuscularized versus partially muscularized versus fully muscularized small pulmonary arteries), and right heart hypertrophy." |
| More detail of all Human literatures about PDE1A | |
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Pathways and Diseases |
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Pathway | Taste transduction;KEGG PATHWAY;hsa04742 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Purine metabolism;KEGG PATHWAY;hsa00230 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Disease | Depression;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 5136 |
Links to all GeneRIF Items | 5136 |
Links to iHOP | 5136 |
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Sequence Information |
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Nucleotide Sequence |
>5136 : length: 1608 atggggtctagtgccacagagattgaagaattggaaaacaccacttttaagtatcttaca ggagaacagactgaaaaaatgtggcagcgcctgaaaggaatactaagatgcttggtgaag cagctggaaagaggtgatgttaacgtcgtcgacttaaagaagaatattgaatatgcggca tctgtgctggaagcagtttatatcgatgaaacaagaagacttctggatactgaagatgag ctcagtgacattcagactgactcagtcccatctgaagtccgggactggttggcttctacc tttacacggaaaatggggatgacaaaaaagaaacctgaggaaaaaccaaaatttcggagc attgtgcatgctgttcaagctggaatttttgtggaaagaatgtaccgaaaaacatatcat atggttggtttggcatatccagcagctgtcatcgtaacattaaaggatgttgataaatgg tctttcgatgtatttgccctaaatgaagcaagtggagagcatagtctgaagtttatgatt tatgaactgtttaccagatatgatcttatcaaccgtttcaagattcctgtttcttgccta atcacctttgcagaagctttagaagttggttacagcaagtacaaaaatccatatcacaat ttgattcatgcagctgatgtcactcaaactgtgcattacataatgcttcatacaggtatc atgcactggctcactgaactggaaattttagcaatggtctttgctgctgccattcatgat tatgagcatacagggacaacaaacaactttcacattcagacaaggtcagatgttgccatt ttgtataatgatcgctctgtccttgagaatcaccacgtgagtgcagcttatcgacttatg caagaagaagaaatgaatatcttgataaatttatccaaagatgactggagggatcttcgg aacctagtgattgaaatggttttatctacagacatgtcaggtcacttccagcaaattaaa aatataagaaacagtttgcagcagcctgaagggattgacagagccaaaaccatgtccctg attctccacgcagcagacatcagccacccagccaaatcctggaagctgcattatcggtgg accatggccctaatggaggagtttttcctgcagggagataaagaagctgaattagggctt ccattttccccactttgtgatcggaagtcaaccatggtggcccagtcacaaataggtttc atcgatttcatagtagagccaacattttctcttctgacagactcaacagagaaaattgtt attcctcttatagaggaagcctcaaaagccgaaacttcttcctatgtggcaagcagctca accaccattgtggggttacacattgctgatgcactaagacgatcaaatacaaaaggctcc atgagtgatgggtcctattccccagactactcccttgcagcagtggacctgaagagtttc aagaacaacctggtggacatcattcagcagaacaaagagaggtggaaagagttagctgca caagaagcaagaaccagttcacagaagtgtgagtttattcatcagtaa |
Protein Sequence |
>5136 : length: 535 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ |