| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5157 |
Name | PDGFRL |
Synonym | PDGRL|PRLTS;platelet-derived growth factor receptor-like;PDGFRL;platelet-derived growth factor receptor-like |
Definition | PDGF receptor beta-like tumor suppressor|PDGFR-like protein|platelet-derived growth factor receptor-like protein|platelet-derived growth factor-beta-like tumor suppressor |
Position | 8p22-p21.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | CONCLUSIONS: We suggest that dual inhibition of PDGF receptor and Src kinases potently inhibits mitogenic and motogenic responses to growth factors in PASMCs and pulmonary vascular remodeling in vivo so that dual inhibition may represent an alternative therapeutic approach for pulmonary arterial hypertension. |
| More detail of all Human literatures about PDGFRL | |
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Pathways and Diseases |
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Pathway | PDGF signaling pathway;PANTHER;P00047 |
Disease | Colorectal cancer;OMIM |
Disease | Hepatocellular cancer;OMIM |
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External Links |
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Links to Entrez Gene | 5157 |
Links to all GeneRIF Items | 5157 |
Links to iHOP | 5157 |
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Sequence Information |
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Nucleotide Sequence |
>5157 : length: 1128 atgaaggtctggctgctgcttggtcttctgctggtgcacgaagcgctggaggatgttact ggccaacaccttcccaagaacaagcgtccaaaagaaccaggagagaatagaatcaaacct accaacaagaaggtgaagcccaaaattcctaaaatgaaggacagggactcagccaattca gcaccaaagacgcagtctatcatgatgcaagtgctggataaaggtcgcttccagaaaccc gccgctaccctgagtctgctggcggggcaaactgtagagcttcgatgtaaagggagtaga attgggtggagctaccctgcgtatctggacacctttaaggattctcgcctcagcgtcaag cagaatgagcgctacggccagttgactctggtcaactccacctcggcagacacaggtgaa ttcagctgctgggtgcagctctgcagcggctacatctgcaggaaggacgaggccaaaacg ggctccacctacatcttttttacagagaaaggagaactctttgtaccttctcccagctac ttcgatgttgtctacttgaacccggacagacaggctgtggttccttgtcgggtgaccgtg ctgtcggccaaagtcacgctccacagggaattcccagccaaggagatcccagccaatgga acggacattgtttatgacatgaagcggggctttgtgtatctgcaacctcattccgagcac cagggtgtggtttactgcagggcggaggccgggggcagatctcagatctccgtcaagtac cagctgctctacgtggcggttcccagtggccctccctcaacaaccatcttggcttcttca aacaaagtgaaaagtggggacgacatcagtgtgctctgcactgtcctgggggagcccgat gtggaggtggagttcacctggatcttcccagggcagaaggatgaaaggcctgtgacgatc caagacacttggaggttgatccacagaggactgggacacaccacgagaatctcccagagt gtcattacagtggaagactttgagacgattgatgcaggatattacatttgcactgctcag aatcttcaaggacagaccacagtagctaccactgttgagttttcctga |
Protein Sequence |
>5157 : length: 375 MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANS APKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVK QNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSY FDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ NLQGQTTVATTVEFS |