| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5164 |
Name | PDK2 |
Synonym | PDHK2|PDKII;pyruvate dehydrogenase kinase, isozyme 2;PDK2;pyruvate dehydrogenase kinase, isozyme 2 |
Definition | PDH kinase 2|pyruvate dehydrogenase kinase, isoenzyme 2|pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial |
Position | 17q21.33 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | "Pyruvate dehydrogenase kinase (PDK) is pathologically activated in both conditions. This enzyme phosphorylates and inhibits pyruvate dehydrogenase (PDH). PDH catalyses the irreversible oxidation of pyruvate, yielding acetylCoA and CO2 and is a key enzyme controlling the rate of oxidative metabolism. PDK activation thus impairs the Krebs' cycle and creates a glycolytic shift in glucose metabolism. ". |
| More detail of all Human literatures about PDK2 | |
|
Pathways and Diseases |
|
Pathway | Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046 |
Pathway | TCA cycle;PANTHER;P00051 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Pathway | mtor signaling pathway;PID BioCarta;100101 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | regulation of eif-4e and p70s6 kinase;PID BioCarta;100178 |
|
External Links |
|
Links to Entrez Gene | 5164 |
Links to all GeneRIF Items | 5164 |
Links to iHOP | 5164 |
|
Sequence Information |
|
Nucleotide Sequence |
>5164 : length: 1032 atgaaagagatcaacctgcttcccgaccgagtgctgagcacaccctccgtgcagctggtg cagagctggtatgtccagagcctcctggacatcatggagttcctggacaaggatcccgag gaccatcgcaccctgagccagttcactgacgccctggtcaccatccggaaccggcacaac gacgtggtgcccaccatggcacaaggcgtgcttgagtacaaggacacctacggcgatgac cccgtctccaaccagaacatccagtacttcctggaccgcttctacctcagccgcatctcc atccgcatgctcatcaaccagcacaccctcatctttgatggcagcaccaacccagcccat cccaaacacatcggcagcatcgaccccaactgcaacgtctctgaggtggtcaaagatgcc tacgacatggctaagctcctgtgtgacaagtattacatggcctcacctgacctggagatc caggagatcaatgcagccaactccaaacagccgattcacatggtctacgtcccctcccac ctctaccacatgctctttgagctcttcaagaatgccatgagggcgactgtggaaagccat gagtccagcctcattctcccacccatcaaggtcatggtggccttgggtgaggaagatctg tccatcaagatgagtgaccgaggtgggggtgttcccttgaggaagattgagcgactcttc agctacatgtactccacagcacccaccccccagcctggcaccgggggaacgccgctggct ggctttggttatgggctccccatttcccgcctctacgccaagtacttccagggagacctg cagctcttctccatggaaggctttgggaccgatgctgtcatctatctcaaggccctgtcc acggactcggtggagcgcctgcctgtctacaacaagtcagcctggcgccactaccagacc atccaggaggccggcgactggtgtgtgcccagcacggagcccaagaacacgtccacgtac cgcgtcagctaa |
Protein Sequence |
>5164 : length: 343 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHN DVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAH PKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSH LYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLF SYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALS TDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS |