| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5265 |
Name | SERPINA1 |
Synonym | A1A|A1AT|AAT|PI|PI1|PRO2275|alpha1AT;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1;SERPINA1;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Definition | alpha-1 protease inhibitor|alpha-1-antiproteinase|alpha-1-antitrypsin|alpha-1-antitrypsin null|protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin|serine (or cysteine) proteinase inhibitor, clade A, member 1|serpin A1 |
Position | 14q32.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Regulation of kininogen gene expression and localization in the lung after monocrotaline-induced pulmonary hypertension in rats. |
| More detail of all Rat literatures about SERPINA1 | |
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Pathways and Diseases |
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Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | FOXA1 transcription factor network;PID Curated;200194 |
Disease | chronic obstructive airways disease.;GAD |
Disease | alpha 1-antitrypsin indicate a single origin for deficiency allele PI Z;GAD |
Disease | heart disease, ischemic;GAD |
Disease | cerebrovascular disease, ischemic;GAD |
Disease | Emphysema due to AAT deficiency;OMIM |
Disease | Hemorrhagic diathesis due to 'antithrombin' Pittsburgh;OMIM |
Disease | IMMUNE;GAD |
Disease | HIV;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | lung function;GAD |
Disease | psoriasis;GAD |
Disease | Emphysema-cirrhosis, due to AAT deficiency;OMIM |
Disease | Serum alpha 1-antitrypsin deficiency;GAD |
Disease | alphal-antitrypsin deficiency;GAD |
Disease | alpha 1-Antitrypsin Deficiency;GAD |
Disease | INFECTION;GAD |
Disease | cystic fibrosis;GAD |
Disease | Pulmonary disease, chronic obstructive, susceptibility to;OMIM |
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External Links |
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Links to Entrez Gene | 5265 |
Links to all GeneRIF Items | 5265 |
Links to iHOP | 5265 |
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Sequence Information |
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Nucleotide Sequence |
>5265 : length: 1257 atgccgtcttctgtctcgtggggcatcctcctgctggcaggcctgtgctgcctggtccct gtctccctggctgaggatccccagggagatgctgcccagaagacagatacatcccaccat gatcaggatcacccaaccttcaacaagatcacccccaacctggctgagttcgccttcagc ctataccgccagctggcacaccagtccaacagcaccaatatcttcttctccccagtgagc atcgctacagcctttgcaatgctctccctggggaccaaggctgacactcacgatgaaatc ctggagggcctgaatttcaacctcacggagattccggaggctcagatccatgaaggcttc caggaactcctccgtaccctcaaccagccagacagccagctccagctgaccaccggcaat ggcctgttcctcagcgagggcctgaagctagtggataagtttttggaggatgttaaaaag ttgtaccactcagaagccttcactgtcaacttcggggacaccgaagaggccaagaaacag atcaacgattacgtggagaagggtactcaagggaaaattgtggatttggtcaaggagctt gacagagacacagtttttgctctggtgaattacatcttctttaaaggcaaatgggagaga ccctttgaagtcaaggacaccgaggaagaggacttccacgtggaccaggtgaccaccgtg aaggtgcctatgatgaagcgtttaggcatgtttaacatccagcactgtaagaagctgtcc agctgggtgctgctgatgaaatacctgggcaatgccaccgccatcttcttcctgcctgat gaggggaaactacagcacctggaaaatgaactcacccacgatatcatcaccaagttcctg gaaaatgaagacagaaggtctgccagcttacatttacccaaactgtccattactggaacc tatgatctgaagagcgtcctgggtcaactgggcatcactaaggtcttcagcaatggggct gacctctccggggtcacagaggaggcacccctgaagctctccaaggccgtgcataaggct gtgctgaccatcgacgagaaagggactgaagctgctggggccatgtttttagaggccata cccatgtctatcccccccgaggtcaagttcaacaaaccctttgtcttcttaatgattgaa caaaataccaagtctcccctcttcatgggaaaagtggtgaatcccacccaaaaataa |
Protein Sequence |
>5265 : length: 418 MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFS LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQ INDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTV KVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFL ENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKA VLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK |