Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

59341

Name

TRPV4

Synonym

CMT2C|HMSN2C|OTRPC4|SMAL|SPSMA|SSQTL1|TRP12|VRL2|VROAC;transient receptor potential cation channel, subfamily V, member 4;TRPV4;transient receptor potential cation channel, subfamily V, member 4

Definition

OSM9-like transient receptor potential channel 4|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential protein 12|vanilloid receptor-like

Position

12q24.1

Gene Type

protein-coding

PAH Type

Description

HPH

Relevance of the TRPV4-RyR2 signaling pathway under hypoxic conditions that may lead to pulmonary hypertension.
More detail of all Rat literatures about TRPV4

External Links

Links to Entrez Gene

59341

Links to all GeneRIF Items

59341

Links to iHOP

59341

Sequence Information

Nucleotide Sequence

>59341 : length: 2475
atggcggattccagcgaaggcccccgcgcggggcccggggaggtggctgagctccccggg
gatgagagtggcaccccaggtggggaggcttttcctctctcctccctggccaatctgttt
gagggggaggatggctccctttcgccctcaccggctgatgccagtcgccctgctggccca
ggcgatgggcgaccaaatctgcgcatgaagttccagggcgccttccgcaagggggtgccc
aaccccatcgatctgctggagtccaccctatatgagtcctcggtggtgcctgggcccaag
aaagcacccatggactcactgtttgactacggcacctatcgtcaccactccagtgacaac
aagaggtggaggaagaagatcatagagaagcagccgcagagccccaaagcccctgcccct
cagccgccccccatcctcaaagtcttcaaccggcctatcctctttgacatcgtgtcccgg
ggctccactgctgacctggacgggctgctcccattcttgctgacccacaagaaacgccta
actgatgaggagtttcgagagccatctacggggaagacctgcctgcccaaggccttgctg
aacctgagcaatggccgcaacgacaccatccctgtgctgctggacatcgcggagcgcacc
ggcaacatgagggagttcattaactcgcccttccgtgacatctactatcgaggggagctg
cccctgtcgctggctgcctgcaccaaccagccccacattgtcaactacctgacggagaac
ccccacaagaaggcggacatgcggcgccaggactcgcgaggcaacacagtgctgcatgcg
ctggtggccattgctgacaacacccgtgagaacaccaagtttgttaccaagatgtacgac
ctgctgctgctcaagtgtgcccgcctcttccccgacagcaacctggaggccgtgctcaac
aacgacggcctctcgcccctcatgatggctgccaagacgggcaagattgggatctttcag
cacatcatccggcgggaggtgacggatgaggacacacggcacctgtcccgcaagttcaag
gactgggcctatgggccagtgtattcctcgctttatgacctctcctccctggacacgtgt
ggggaagaggcctccgtgctggagatcctggtgtacaacagcaagattgagaaccgccac
gagatgctggctgtggagcccatcaatgaactgctgcgggacaagtggcgcaagttcggg
gccgtctccttctacatcaacgtggtctcctacctgtgtgccatggtcatcttcactctc
accgcctactaccagccgctggagggcacaccgccgtacccttaccgcaccacggtggac
tacctgcggctggctggcgaggtcattacgctcttcactggggtcctgttcttcttcacc
aacatcaaagacttgttcatgaagaaatgccctggagtgaattctctcttcattgatggc
tccttccagctgctctacttcatctactctgtcctggtgatcgtctcagcagccctctac
ctggcagggatcgaggcctacctggccgtgatggtctttgccctggtcctgggctggatg
aatgccctttacttcacccgtgggctgaagctgacggggacctatagcatcatgatccag
aagattctcttcaaggaccttttccgattcctgctcgtctacttgctcttcatgatcggc
tacgcttcagccctggtctccctcctgaacccgtgtgccaacatgaaggtgtgcaatgag
gaccagaccaactgcacagtgcccacttacccctcgtgccgtgacagcgagaccttcagc
accttcctcctggacctgtttaagctgaccatcggcatgggcgacctggagatgctgagc
agcaccaagtaccccgtggtcttcatcatcctgctggtgacctacatcatcctcaccttt
gtgctgctcctcaacatgctcattgccctcatgggcgagacagtgggccaggtctccaag
gagagcaagcacatctggaagctgcagtgggccaccaccatcctggacattgagcgctcc
ttccccgtattcctgaggaaggccttccgctctggggagatggtcaccgtgggcaagagc
tcggacggcactcctgaccgcaggtggtgcttcagggtggatgaggtgaactggtctcac
tggaaccagaacttgggcatcatcaacgaggacccgggcaagaatgagacctaccagtat
tatggcttctcgcataccgtgggccgcctccgcagggatcgctggtcctcggtggtaccc
cgcgtggtggaactgaacaagaactcgaacccggacgaggtggtggtgcctctggacagc
atggggaacccccgctgcgatggccaccagcagggttacccccgcaagtggaggactgat
gacgccccgctctag

Protein Sequence

>59341 : length: 824
MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGEL
PLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYD
LLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFK
DWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFG
AVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFT
NIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWM
NALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNE
DQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTF
VLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKS
SDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVP
RVVELNKNSNPDEVVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL



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