| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6259 |
Name | RYK |
Synonym | D3S3195|JTK5|JTK5A|RYK1;receptor-like tyrosine kinase;RYK;receptor-like tyrosine kinase |
Definition | JTK5A protein tyrosine kinase|hydroxyaryl-protein kinase|tyrosine-protein kinase RYK |
Position | 3q22 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "We observed linkage evidence in four regions: 3q22 ([median log of the odds (LOD) = 3.43]), 3p12 (median LOD) = 2.35), 2p22 (median LOD = 2.21), and 13q21 (median LOD = 2.09). When used in conjunction with the non-parametric bootstrap, our approach yields high-resolution to identify candidate gene regions containing putative BMPR2-interacting genes. Imputation of the disease model by LOD-score maximization indicates that the 3q22 locus alone predicts most FPAH cases in BMPR2 mutation carriers, providing strong evidence that BMPR2 and the 3q22 locus interact epistatically." |
| More detail of all Human literatures about RYK | |
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Pathways and Diseases |
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Pathway | Wnt signaling network;PID Curated;200055 |
Disease | Cleft palate;FunDO |
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External Links |
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Links to Entrez Gene | 6259 |
Links to all GeneRIF Items | 6259 |
Links to iHOP | 6259 |
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Sequence Information |
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Nucleotide Sequence |
>6259 : length: 1833 atgcgtggggcggcgcggctggggcggccgggccggagttgcctcccgggggcccgcggc ctgagggccccgccgccgccgccgctgctgcttctgcttgcgctgttgccgctgctgccc gcgcctggcgctgccgccgcccccgccccgcggcccccggagctgcagtcggcttccgcg gggcccagcgtgagtctctacctgagcgaggacgaggtgcgccggctgatcggtcttgat gcagaactttattatgtgagaaatgaccttattagtcactacgctctatcctttagtctg ttagtacccagtgagacaaatttcctgcacttcacctggcatgcgaagtccaaggttgaa tataagctgggattccaagtggacaatgttttggcaatggatatgccccaggtcaacatt tctgttcagggggaagttccacgcactttatcagtgtttcgggtagagctttcctgtact ggcaaagtagattctgaagttatgatactaatgcagctcaacttgacagtaaattcttca aaaaattttaccgtcttaaattttaaacgaaggaaaatgtgctacaaaaaacttgaagaa gtaaaaacttcagccttggacaaaaacactagcagaactatttatgatcctgtacatgca gctccaaccacttctacgcgtgtgttttatattagtgtaggggtttgttgtgcagtaata tttctcgtagcaataatattagctgttttgcaccttcatagtatgaaaaggattgaactg gatgacagcattagtgccagcagtagttcccaagggctgtctcagccatccacccagacg actcagtatctgagagcagacacgcccaacaatgcaactcctatcaccagctccttaggt tatcctaccttgcggatagagaagaacgacttgagaagtgtcactcttttggaggccaaa ggcaaggtgaaggatatagcaatatccagagagaggataactctaaaagatgtactccaa gaaggtacttttgggcgtattttccatgggattttaatagatgaaaaagatccaaataaa gaaaaacaagcatttgtcaaaacagttaaagatcaagcttctgaaattcaggtgacaatg atgctcactgaaagttgtaagctgcgaggtcttcatcacagaaatcttcttcctattact catgtgtgtatagaagaaggagaaaagcccatggtgatattgccttacatgaattggggg aatcttaaattgtttttacgacagtgcaagttagtagaggccaataatccacaggcaatt tctcagcaagacctggtacacatggctattcagattgcctgtggaatgagctacctggcc agaagggaagtcatccacaaagacctggctgccaggaactgtgtcattgatgacacactt caagttaagatcacagacaatgccctctccagagacttgttccccatggactatcactgt ctgggggacaatgaaaacaggccagttcgttggatggctcttgaaagtctggttaataac gagttctctagcgctagtgatgtgtgggcctttggagtgacgctgtgggaactcatgact ctgggccagactccctacgtggacattgaccccttcgagatggccgcatacctgaaagat ggttaccgaatagcccagccaatcaactgtcctgatgaattatttgctgtgatggcctgt tgctgggccttagatccagaggagaggcccaagtttcagcagctggtacagtgcctaaca gagtttcatgcagccctgggggcctacgtctga |
Protein Sequence |
>6259 : length: 610 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT EFHAALGAYV |