| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7048 |
Name | TGFBR2 |
Synonym | AAT3|FAA3|LDS1B|LDS2B|MFS2|RIIC|TAAD2|TGFR-2|TGFbeta-RII;transforming growth factor, beta receptor II (70/80kDa);TGFBR2;transforming growth factor, beta receptor II (70/80kDa) |
Definition | TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II (70/80kDa) isoform 1|transforming growth factor, beta receptor II (70/80 |
Position | 3p22 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome." |
PAH | Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. |
PH | "The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension." |
| More detail of all Human literatures about TGFBR2 | |
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Pathways and Diseases |
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Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | ctcf: first multivalent nuclear factor;PID BioCarta;100194 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ALK1 signaling events;PID Curated;200126 |
Pathway | nfkb activation by nontypeable hemophilus influenzae;PID BioCarta;100088 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Glypican 1 network;PID Curated;200021 |
Pathway | Signaling by TGF beta;Reactome;REACT:6844 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | alk in cardiac myocytes;PID BioCarta;100244 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Disease | Colorectal cancer;KEGG DISEASE;H00020 |
Disease | tonometry;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | Loeys-Dietz syndrome, type 1B;OMIM |
Disease | Loeys-Dietz syndrome, type 2B;OMIM |
Disease | gastric cancer;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Tonometry;NHGRI |
Disease | CANCER;GAD |
Disease | Esophageal cancer, somatic;OMIM |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Colorectal cancer, hereditary nonpolyposis, type 6;OMIM |
Disease | Aortic Aneurysm, Abdominal;GAD |
Disease | stomach cancer;GAD |
Disease | colorectal cancer;GAD |
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External Links |
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Links to Entrez Gene | 7048 |
Links to all GeneRIF Items | 7048 |
Links to iHOP | 7048 |
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Sequence Information |
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Nucleotide Sequence |
>7048 : length: 1779 atgggtcgggggctgctcaggggcctgtggccgctgcacatcgtcctgtggacgcgtatc gccagcacgatcccaccgcacgttcagaagtcggatgtggaaatggaggcccagaaagat gaaatcatctgccccagctgtaataggactgcccatccactgagacatattaataacgac atgatagtcactgacaacaacggtgcagtcaagtttccacaactgtgtaaattttgtgat gtgagattttccacctgtgacaaccagaaatcctgcatgagcaactgcagcatcacctcc atctgtgagaagccacaggaagtctgtgtggctgtatggagaaagaatgacgagaacata acactagagacagtttgccatgaccccaagctcccctaccatgactttattctggaagat gctgcttctccaaagtgcattatgaaggaaaaaaaaaagcctggtgagactttcttcatg tgttcctgtagctctgatgagtgcaatgacaacatcatcttctcagaagaatataacacc agcaatcctgacttgttgctagtcatatttcaagtgacaggcatcagcctcctgccacca ctgggagttgccatatctgtcatcatcatcttctactgctaccgcgttaaccggcagcag aagctgagttcaacctgggaaaccggcaagacgcggaagctcatggagttcagcgagcac tgtgccatcatcctggaagatgaccgctctgacatcagctccacgtgtgccaacaacatc aaccacaacacagagctgctgcccattgagctggacaccctggtggggaaaggtcgcttt gctgaggtctataaggccaagctgaagcagaacacttcagagcagtttgagacagtggca gtcaagatctttccctatgaggagtatgcctcttggaagacagagaaggacatcttctca gacatcaatctgaagcatgagaacatactccagttcctgacggctgaggagcggaagacg gagttggggaaacaatactggctgatcaccgccttccacgccaagggcaacctacaggag tacctgacgcggcatgtcatcagctgggaggacctgcgcaagctgggcagctccctcgcc cgggggattgctcacctccacagtgatcacactccatgtgggaggcccaagatgcccatc gtgcacagggacctcaagagctccaatatcctcgtgaagaacgacctaacctgctgcctg tgtgactttgggctttccctgcgtctggaccctactctgtctgtggatgacctggctaac agtgggcaggtgggaactgcaagatacatggctccagaagtcctagaatccaggatgaat ttggagaatgttgagtccttcaagcagaccgatgtctactccatggctctggtgctctgg gaaatgacatctcgctgtaatgcagtgggagaagtaaaagattatgagcctccatttggt tccaaggtgcgggagcacccctgtgtcgaaagcatgaaggacaacgtgttgagagatcga gggcgaccagaaattcccagcttctggctcaaccaccagggcatccagatggtgtgtgag acgttgactgagtgctgggaccacgacccagaggcccgtctcacagcccagtgtgtggca gaacgcttcagtgagctggagcatctggacaggctctcggggaggagctgctcggaggag aagattcctgaagacggctccctaaacactaccaaatag |
Protein Sequence |
>7048 : length: 592 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINND MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK |