| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7222 |
Name | TRPC3 |
Synonym | TRP3;transient receptor potential cation channel, subfamily C, member 3;TRPC3;transient receptor potential cation channel, subfamily C, member 3 |
Definition | hTrp-3|short transient receptor potential channel 3|transient receptor protein 3 |
Position | 4q27 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. |
PAH | Recent reports of elevated transient receptor potential (TRP) calcium channels TRP3 and TRP6 in PA SMCs from IPAH patients indicated that inhibition of these channels can repress the heightened proliferation observed in SMCs. Inhibition of PKA or activation of cAMP seem to have a similar effect. |
PH | Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. |
| More detail of all Human literatures about TRPC3 | |
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Pathways and Diseases |
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Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Disease | Heart failure;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
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External Links |
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Links to Entrez Gene | 7222 |
Links to all GeneRIF Items | 7222 |
Links to iHOP | 7222 |
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Sequence Information |
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Nucleotide Sequence |
>7222 : length: 2766 atgtccaccaaggtcaggaagtgcaaagaacaagcaagggtgaccttcccggcgccggag gaggaggaagacgagggcgaggacgagggcgcggagccgcagcgccgccgccggggctgg aggggcgtcaacggggggctggagccgcgctcggcgccctcgcagcgggagccgcacggc tactgcccgccgcccttctcccacgggccggacctgtccatggagggaagcccatccctg agacgcatgacagtgatgcgggagaagggccggcgccaggctgtcaggggcccggccttc atgttcaatgaccgcggcaccagcctcaccgccgaggaggagcgcttcctcgacgccgcc gagtacggcaacatcccagtggtgcgcaagatgctggaggagtccaagacgctgaacgtc aactgcgtggactacatgggccagaacgcgctgcagctggctgtgggcaacgagcacctg gaggtgaccgagctgctgctcaagaaggagaacctggcgcgcattggcgacgccctgctg ctcgccatcagcaagggctacgtgcgcatcgtagaggccatcctcaaccaccctggcttc gcggccagcaagcgtctcactctgagcccctgtgagcaggagctgcaggacgacgacttc tacgcttacgacgaggacggcacgcgcttctcgccggacatcacccccatcatcctggcg gcgcactgccagaaatacgaagtggtgcacatgctgctgatgaagggtgccaggatcgag cggccgcacgactatttctgcaagtgcggggactgcatggagaagcagaggcacgactcc ttcagccactcacgctcgaggatcaatgcctacaaggggctggccagcccggcttacctc tcattgtccagcgaggacccggtgcttacggccctagagctcagcaacgagctggccaag ctggccaacatagagaaggagttcaagaatgactatcggaagctctccatgcaatgcaaa gactttgtagtgggtgtgctggatctctgccgagactcagaagaggtagaagccattctg aatggagatctggaatcagcagagcctctggaggtacacaggcacaaagcttcattaagt cgtgtcaaacttgccattaagtatgaagtcaaaaagtttgtggctcatcccaactgccag cagcagctcttgacgatctggtatgagaacctctcaggcctaagggagcagaccatagct atcaagtgtctcgttgtgctggtcgtggccctgggccttccattcctggccattggctac tggatcgcaccttgcagcaggctggggaaaattctgcgaagcccttttatgaagtttgta gcacatgcagcttctttcatcatcttcctgggtctgcttgtgttcaatgcctcagacagg ttcgaaggcatcaccacgctgcccaatatcacagttactgactatcccaaacagatcttc agggtgaaaaccacccagtttacatggactgaaatgctaattatggtctgggttcttgga atgatgtggtctgaatgtaaagagctctggctggaaggacctagggaatacattttgcag ttgtggaatgtgcttgactttgggatgctgtccatcttcattgctgctttcacagccaga ttcctagctttccttcaggcaacgaaggcacaacagtatgtggacagttacgtccaagag agtgacctcagtgaagtgacactcccaccagagatacagtatttcacttatgctagagat aaatggctcccttctgaccctcagattatatctgaaggcctttatgccatagctgttgtg ctcagcttctctcggattgcgtacatcctccctgcaaatgagagctttggccccctgcag atctctcttggaaggactgtaaaggacatattcaagttcatggtcctctttattatggtg ttttttgcctttatgattggcatgttcatactttattcttactaccttggggctaaagtt aatgctgcttttaccactgtagaagaaagtttcaagactttattttggtcaatatttggg ttgtctgaagtgacttccgttgtgctcaaatatgatcacaaattcatagaaaatattgga tacgttctttatggaatatacaatgtaactatggtggtcgttttactcaacatgctaatt gctatgattaatagctcatatcaagaaattgaggatgacagtgatgtagaatggaagttt gctcgttcaaaactttggttatcctattttgatgatggaaaaacattacctccacctttc agtctagttcctagtccaaaatcatttgtttatttcatcatgcgaattgttaactttccc aaatgcagaaggagaaggcttcagaaggatatagaaatgggaatgggtaactcaaagtcc aggttaaacctcttcactcagtctaactcaagagtttttgaatcacacagttttaacagc attctcaatcagccaacacgttatcagcagataatgaaaagacttataaagcggtatgtt ttgaaagcacaagtagacaaagaaaatgatgaagttaatgaaggtgaattaaaagaaatc aagcaagatatctccagccttcgttatgaacttttggaagacaagagccaagcaactgag gaattagccattctaattcataaacttagtgagaaactgaatcccagcatgctgagatgt gaatga |
Protein Sequence |
>7222 : length: 921 MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHG YCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAA EYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALL LAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILA AHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYL SLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAIL NGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIA IKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDR FEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQ LWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARD KWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMV FFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIG YVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPF SLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNS ILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATE ELAILIHKLSEKLNPSMLRCE |