Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7422

Name

VEGFA

Synonym

MVCD1|VEGF|VPF;vascular endothelial growth factor A;VEGFA;vascular endothelial growth factor A

Definition

vascular permeability factor

Position

6p12

Gene Type

protein-coding

PAH Type

Description

HPH

ET-1 and VEGF play important roles in the pathogenesis of hypoxic pulmonary hypertension.

HPH

VEGF and ET-1 participate the muscularization of pulmonary vessels during hypoxia and play an important role in the process of hypoxic pulmonary hypertension in rats.

HPH

Hypoxic pulmonary hypertension is closely associated with increased expression of HIF-1alpha and VEGF in high altitide areas.

PAH

[Different expression and significance of VEGF and PCNA in aorta and pulmonary artery smooth muscle cells of rats with hypoxia pulmonary hypertension].

PAH

"Vascular endothelial growth factor, lipoporotein-associated phospholipase A2, sP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemic lupus erithematosus."

PAH

Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis.

PAH

"Expression of HIF-1 alpha, VEGF and EPO in peripheral blood from patients with two cardiac abnormalities associated with hypoxia."
More detail of all Rat literatures about VEGFA

Pathways and Diseases

Pathway

S1P3 pathway;PID Curated;200035

Pathway

Neurophilin interactions with VEGF and VEGFR;PID Reactome;500650

Pathway

Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060

Pathway

Signaling events mediated by TCPTP;PID Curated;200065

Pathway

HIF-1-alpha transcription factor network;PID Curated;200172

Pathway

VEGFR1 specific signals;PID Curated;200151

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

VEGF signaling pathway;KEGG PATHWAY;hsa04370

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

S1P1 pathway;PID Curated;200071

Pathway

HIF-2-alpha transcription factor network;PID Curated;200030

Pathway

Glypican 1 network;PID Curated;200021

Pathway

Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161

Pathway

VEGF signaling pathway;PANTHER;P00056

Pathway

hypoxia-inducible factor in the cardivascular system;PID BioCarta;100145

Pathway

Angiogenesis;PANTHER;P00005

Pathway

mTOR signaling pathway;KEGG PATHWAY;hsa04150

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

actions of nitric oxide in the heart;PID BioCarta;100094

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Integrins in angiogenesis;PID Curated;200109

Pathway

Signaling by VEGF;Reactome;REACT:12529

Pathway

vegf hypoxia and angiogenesis;PID BioCarta;100006

Disease

Microvascular complications of diabetes 1;OMIM

Disease

Cancer;FunDO

Disease

longevity;GAD

Disease

IMMUNE;GAD

Disease

endometriosis;GAD

Disease

kawasaki disease;GAD

Disease

Pre-Eclampsia;GAD

Disease

Neovascularization, Pathologic;GAD

Disease

Malaria;FunDO

Disease

diabetes, type 1 diabetic nephropathy;GAD

Disease

sarcoidosis;GAD

Disease

diabetes, type 2 retinopathy, diabetic;GAD

Disease

Macular Degeneration;GAD

Disease

myocardial infarct;GAD

Disease

Atherosclerosis;FunDO

Disease

Polyneuropathy;FunDO

Disease

Waist-hip ratio;NHGRI

Disease

pregnancy loss, recurrent;GAD

Disease

urinary calculus;GAD

Disease

kidney cancer;GAD

Disease

Stomach Neoplasms;GAD

Disease

vascular endothelial growth factor levels;GAD

Disease

nephropathy, IgA;GAD

Disease

oral cancer;GAD

Disease

Mucocutaneous lymph node syndrome;FunDO

Disease

atherosclerosis, coronary;GAD

Disease

prostate cancer;GAD

Disease

Systemic infection;FunDO

Disease

diabetes, type 1;GAD

Disease

vascular endothelial growth factor;GAD

Disease

Heart Septal Defects, Ventricular;GAD

Disease

cutaneous malignant melanoma;GAD

Disease

acute renal allograft rejection;GAD

Disease

CANCER;GAD

Disease

diabetic nephropathy;GAD

Disease

Carcinoma, Squamous Cell;GAD

Disease

Pterygium;GAD

Disease

benzene haematotoxicity;GAD

Disease

Type 2 diabetes;NHGRI

Disease

Macular degeneration;FunDO

Disease

AGING;GAD

Disease

ALS/amyotrophic lateral sclerosis;GAD

Disease

hemodialysis;GAD

Disease

type 2 diabetes;GAD

Disease

Henoch-Schonlein purpura;GAD

Disease

psoriasis;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Diabetic Retinopathy in Type 2 Diabetes;GAD

Disease

rheumatoid arthritis;GAD

Disease

retinopathy, diabetic;GAD

Disease

colorectal cancer;GAD

Disease

retinopathy;GAD

Disease

Capillaries disease;FunDO

Disease

diabetes, type 2;GAD

Disease

18F-fluorodeoxyglucose uptake;GAD

Disease

macular edema;GAD

Disease

CARDIOVASCULAR;GAD

Disease

renal disease, end stage vascular endothelial growth factor;GAD

Disease

Chronic obstructive airway disease;FunDO

Disease

REPRODUCTION;GAD

Disease

Cancers;KEGG DISEASE

Disease

breast cancer;GAD

Disease

Leiomyoma;GAD

Disease

Obesity;FunDO

Disease

coronary artery bypass;GAD

Disease

ovarian cancer;GAD

Disease

stomach cancer;GAD

Disease

Retinopathy of Prematurity;GAD

Disease

Pre-Eclampsia;FunDO

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

preterm delivery;GAD

Disease

Alzheimer's disease;GAD

Disease

stomach cancer vascular endothelial growth factor levels;GAD

Disease

Chronic kidney disease;NHGRI

Disease

bladder cancer;GAD

Disease

Leukoencephalopathy;FunDO

Disease

Mouth Neoplasms;GAD

Disease

heart anomalies, congenital;GAD

Disease

SIDS/sudden infant death syndrome;GAD

Disease

lung cancer;GAD

Disease

VISION;GAD

Disease

nephropathy in other diseases;GAD

Disease

Peptic ulcer;FunDO

Disease

Heart Failure;GAD

Disease

Ventricular Septal Defects;GAD

Disease

Femur Head Necrosis;GAD

Disease

Uterine Neoplasms;GAD

Disease

Diabetes mellitus;FunDO

Disease

respiratory distress syndrome;GAD

Disease

heart transplant complications;GAD

Disease

nephritis, Henoch-Schonlein;GAD

Disease

Familial Mediterranean fever;FunDO

Disease

Myocardial Infarction;GAD

Disease

Kidney failure;FunDO

Disease

giant cell arteritis;GAD

Disease

NEUROLOGICAL;GAD

Disease

spontaneous preterm delivery.;GAD

Disease

RENAL;GAD

External Links

Links to Entrez Gene

7422

Links to all GeneRIF Items

7422

Links to iHOP

7422

Sequence Information

Nucleotide Sequence

>7422 : length: 1239
ctgacggacagacagacagacaccgcccccagccccagctaccacctcctccccggccgg
cggcggacagtggacgcggcggcgagccgcgggcaggggccggagcccgcgcccggaggc
ggggtggagggggtcggggctcgcggcgtcgcactgaaacttttcgtccaacttctgggc
tgttctcgcttcggaggagccgtggtccgcgcgggggaagccgagccgagcggagccgcg
agaagtgctagctcgggccgggaggagccgcagccggaggagggggaggaggaagaagag
aaggaagaggagagggggccgcagtggcgactcggcgctcggaagccgggctcatggacg
ggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcc
cgggcctcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccc
cacagcccgagccggagagggagcgcgagccgcgccggccccggtcgggcctccgaaacc
atgaactttctgctgtcttgggtgcattggagccttgccttgctgctctacctccaccat
gccaagtggtcccaggctgcacccatggcagaaggaggagggcagaatcatcacgaagtg
gtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagaccctggtggac
atcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctg
atgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtcc
aacatcaccatgcagattatgcggatcaaacctcaccaaggccagcacataggagagatg
agcttcctacagcacaacaaatgtgaatgcagaccaaagaaagatagagcaagacaagaa
aaaaaatcagttcgaggaaagggaaaggggcaaaaacgaaagcgcaagaaatcccggtat
aagtcctggagcgtgtacgttggtgcccgctgctgtctaatgccctggagcctccctggc
ccccatccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatccgcag
acgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagtta
aacgaacgtacttgcagatgtgacaagccgaggcggtga

Protein Sequence

>7422 : length: 412
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLG
CSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWT
GEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR



')