| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 7498 |
Name | XDH |
Synonym | XO|XOR;xanthine dehydrogenase;XDH;xanthine dehydrogenase |
Definition | xanthene dehydrogenase|xanthine dehydrogenase/oxidase|xanthine oxidase|xanthine oxidoreductase |
Position | 2p23.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Increased xanthine oxidase activity in idiopathic pulmonary arterial hypertension. |
| More detail of all Human literatures about XDH | |
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Pathways and Diseases |
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Pathway | salvage pathways of adenine, hypoxanthine, and their nucleosides;BioCyc;SALVADEHYPOX-PWY |
Pathway | Purine metabolism;PANTHER;P02769 |
Pathway | Adenine and hypoxanthine salvage pathway;PANTHER;P02723 |
Pathway | purine nucleotides degradation II (aerobic);BioCyc;PWY-6353 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Purine metabolism;KEGG PATHWAY;hsa00230 |
Pathway | Drug metabolism - other enzymes;KEGG PATHWAY;hsa00983 |
Pathway | Caffeine metabolism;KEGG PATHWAY;hsa00232 |
Pathway | Peroxisome;KEGG PATHWAY;hsa04146 |
Pathway | Metabolism of nucleotides;Reactome;REACT:1698 |
Disease | Inherited disorders of nucleotide metabolism;KEGG DISEASE |
Disease | Hypertension;FunDO |
Disease | Genetic disorders;KEGG DISEASE |
Disease | Stomach disease;FunDO |
Disease | Sicca syndrome;FunDO |
Disease | Xanthinuria;KEGG DISEASE;H00192 |
Disease | Asthma;FunDO |
Disease | Xanthinuria, type I;OMIM |
Disease | Breast cancer;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 7498 |
Links to all GeneRIF Items | 7498 |
Links to iHOP | 7498 |
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Sequence Information |
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Nucleotide Sequence |
>7498 : length: 4002 atgacagcagacaaattggttttctttgtgaatggcagaaaggtggtggagaaaaatgca gatccagagacaacccttttggcctacctgagaagaaagttggggctgagtggaaccaag ctcggctgtggagaggggggctgcggggcttgcacagtgatgctctccaagtatgatcgt ctgcagaacaagatcgtccacttttctgccaatgcctgcctggcccccatctgctccttg caccatgttgcagtgacaactgtggaaggaataggaagcaccaagacgaggctgcatcct gtgcaggagagaattgccaaaagccacggctcccagtgcgggttctgcacccctggcatc gtcatgagtatgtacacactgctccggaatcagcccgagcccaccatggaggagattgag aatgccttccaaggaaatctgtgccgctgcacaggctacagacccatcctccagggcttc cggacctttgccagggatggtggatgctgtggaggagatgggaataatccaaattgctgc atgaaccagaagaaagaccactcagtcagcctctcgccatctttattcaaaccagaggag ttcacgcccctggatccaacccaggagcccatttttcccccagagttgctgaggctgaaa gacactcctcggaagcagctgcgatttgaaggggagcgtgtgacgtggatacaggcctca accctcaaggagctgctggacctcaaggctcagcaccctgacgccaagctggtcgtgggg aacacggagattggcattgagatgaagttcaagaatatgctgtttcctatgattgtctgc ccagcctggatccctgagctgaattcggtagaacatggacccgacggtatctcctttgga gctgcttgccccctgagcattgtggaaaaaaccctggtggatgctgttgctaagcttcct gcccaaaagacagaggtgttcagaggggtcctggagcagctgcgctggtttgctgggaag caagtcaagtctgtggcgtccgttggagggaacatcatcactgccagccccatctccgac ctcaaccccgtgttcatggccagtggggccaagctgacacttgtgtccagaggcaccagg agaactgtccagatggaccacaccttcttccctggctacagaaagaccctgctgagcccg gaggagatactgctctccatagagatcccctacagcagggagggggagtatttctcagca ttcaagcaggcctcccggagagaagatgacattgccaaggtaaccagtggcatgagagtt ttattcaagccaggaaccacagaggtacaggagctggccctttgctatggtggaatggcc aacagaaccatctcagccctcaagaccactcagaggcagctttccaagctctggaaggag gagctgctgcaggacgtgtgtgcaggactggcagaggagctgcatctgcctcccgatgcc cctggtggcatggtggacttccggtgcaccctcaccctcagcttcttcttcaagttctac ctgacagtccttcagaagctgggccaagagaacctggaagacaagtgtggtaaactggac cccactttcgccagtgcaactttactgtttcagaaagaccccccagccgatgtccagctc ttccaagaggtgcccaagggtcagtctgaggaggacatggtgggccggcccctgccccac ctggcagcggacatgcaggcctctggtgaggccgtgtactgtgacgacattcctcgctac gagaatgagctgtctctccggctggtcaccagcacccgggcccacgccaagatcaagtcc atagatacatcagaagctaagaaggttccagggtttgtttgtttcatttccgctgatgat gttcctgggagtaacataactggaatttgtaatgatgagacagtctttgcgaaggataag gttacttgtgttgggcatatcattggtgctgtggttgctgacaccccggaacacacacag agagctgcccaaggggtgaaaatcacctatgaagaactaccagccattatcacaattgag gatgctataaagaacaactccttttatggacctgagctgaagatcgagaaaggggaccta aagaaggggttttccgaagcagataatgttgtgtcaggggagatatacatcggtggccaa gagcacttctacctggagactcactgcaccattgctgttccaaaaggcgaggcaggggag atggagctctttgtgtctacacagaacaccatgaagacccagagctttgttgcaaaaatg ttgggggttccagcaaaccggattgtggttcgagtgaagagaatgggaggaggctttgga ggcaaggagacccggagcactgtggtgtccacggcagtggccctggctgcatataagacc ggccgccctgtgcgatgcatgctggaccgtgatgaggacatgctgataactggtggcaga catcccttcctggccagatacaaggttggcttcatgaagactgggacagttgtggctctt gaggtggaccacttcagcaatgtggggaacacccaggatctctctcagagtattatggaa cgagctttattccacatggacaactgctataaaatccccaacatccggggcactgggcgg ctgtgcaaaaccaaccttccctccaacacggccttccggggctttggggggccccagggg atgctcattgccgagtgctggatgagtgaagttgcagtgacctgtgggatgcctgcagag gaggtgcggagaaaaaacctgtacaaagaaggggacctgacacacttcaaccagaagctt gagggtttcaccttgcccagatgctgggaagaatgcctagcaagctctcagtatcatgct cggaagagtgaggttgacaagttcaacaaggagaattgttggaaaaagagaggattgtgc ataattcccaccaagtttggaataagctttacagttccttttctgaatcaggcaggagcc ctacttcatgtgtacacagatggctctgtgctgctgacccacggggggactgagatgggc caaggccttcataccaaaatggtccaggtggccagtagagctctgaaaatccccacctct aagatttatatcagcgagacaagcactaacactgtgcccaacacctctcccacggctgcc tctgtcagcgctgacctcaatggacaggccgtctatgcggcttgtcagaccatcttgaaa aggctggaaccctacaagaagaagaatcccagtggctcctgggaagactgggtcacagct gcctacatggacacagtgagcttgtctgccactgggttttatagaacacccaatctgggc tacagctttgagactaactcagggaaccccttccactacttcagctatggggtggcttgc tctgaagtagaaatcgactgcctaacaggagatcataagaacctccgcacagatattgtc atggatgttggctccagtctaaaccctgccattgatattggacaggtggaaggggcattt gtccagggccttggcctcttcaccctagaggagctacactattcccccgaggggagcctg cacacccgtggccctagcacctacaagatcccggcatttggcagcatccccattgagttc agggtgtccctgctccgcgactgccccaacaagaaggccatctatgcatcgaaggctgtt ggagagccgcccctcttcctggctgcttctatcttctttgccatcaaagatgccatccgt gcagctcgagctcagcacacaggtaataacgtgaaggaactcttccggctagacagccct gccaccccggagaagatccgcaatgcctgcgtggacaagttcaccaccctgtgtgtcact ggtgtcccagaaaactgcaaaccctggtctgtgagggtctaa |
Protein Sequence |
>7498 : length: 1333 MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDR LQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGI VMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQAS TLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFG AACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKE ELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRY ENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDK VTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKM LGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL EGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGA LLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLG YSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAF VQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVT GVPENCKPWSVRV |