| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 775 |
Name | CACNA1C |
Synonym | CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS;calcium channel, voltage-dependent, L type, alpha 1C subunit;CACNA1C;calcium channel, voltage-dependent, L type, alpha 1C subunit |
Definition | DHPR, alpha-1 subunit|calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle|calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit|voltage-dependent L-type calcium channel subunit alpha-1C|voltage-gated L-type calcium channel |
Position | 12p13.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | "PA rings, Western blot, quantitative real-time PCR, in situ hybridization, and luciferase assay were used to investigate the role of miRNA-328 in hypoxic pulmonary hypertension". |
PH | Supplemental Table 1: A list of genes and functional categories that comprises a PHrelevant gene module (PH-module). |
| More detail of all Human literatures about CACNA1C | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Nicotinic acetylcholine receptor signaling pathway;PANTHER;P00044 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Beta2 adrenergic receptor signaling pathway;PANTHER;P04378 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Beta1 adrenergic receptor signaling pathway;PANTHER;P04377 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Cardiac muscle contraction;KEGG PATHWAY;hsa04260 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Disease | Warfarin maintenance dose;NHGRI |
Disease | hypertension;GAD |
Disease | PSYCH;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Timothy syndrome;OMIM |
Disease | Bipolar disorder;NHGRI |
Disease | Brugada syndrome 3;OMIM |
Disease | bipolar disorder;GAD |
Disease | Bipolar disorder and major depressive disorder (combined);NHGRI |
Disease | Atherosclerosis;FunDO |
Disease | warfarin maintenance dose;GAD |
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External Links |
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Links to Entrez Gene | 775 |
Links to all GeneRIF Items | 775 |
Links to iHOP | 775 |
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Sequence Information |
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Nucleotide Sequence |
>775 : length: 6417 atggtcaatgagaatacgaggatgtacattccagaggaaaaccaccaaggttccaactat gggagcccacgccccgcccatgccaacatgaatgccaatgcggcagcggggctggcccct gagcacatccccaccccgggggctgccctgtcgtggcaggcggccatcgacgcagcccgg caggctaagctgatgggcagcgctggcaatgcgaccatctccacagtcagctccacgcag cggaagcggcagcaatatgggaaacccaagaagcagggcagcaccacggccacacgcccg ccccgagccctgctctgcctgaccctgaagaaccccatccggagggcctgcatcagcatt gtcgaatggaaaccatttgaaataattattttactgactatttttgccaattgtgtggcc ttagcgatctatattccctttccagaagatgattccaacgccaccaattccaacctggaa cgagtggaatatctctttctcataatttttacggtggaagcgtttttaaaagtaatcgcc tatggactcctctttcaccccaatgcctacctccgcaacggctggaacctactagatttt ataattgtggttgtggggctttttagtgcaattttagaacaagcaaccaaagcagatggg gcaaacgctctcggagggaaaggggccggatttgatgtgaaggcgctgagggccttccgc gtgctgcgccccctgcggctggtgtccggagtcccaagtctccaggtggtcctgaattcc atcatcaaggccatggtccccctgctgcacatcgccctgcttgtgctgtttgtcatcatc atctacgccatcatcggcttggagctcttcatggggaagatgcacaagacctgctacaac caggagggcatagcagatgttccagcagaagatgacccttccccttgtgcgctggaaacg ggccacgggcggcagtgccagaacggcacggtgtgcaagcccggctgggatggtcccaag cacggcatcaccaactttgacaactttgccttcgccatgctcacggtgttccagtgcatc accatggagggctggacggacgtgctgtactgggtcaatgatgccgtaggaagggactgg ccctggatctattttgttacactaatcatcatagggtcattttttgtacttaacttggtt ctcggtgtgcttagcggagagttttccaaagagagggagaaggccaaggcccggggagat ttccagaagctgcgggagaagcagcagctagaagaggatctcaaaggctacctggattgg atcactcaggccgaagacatcgatcctgagaatgaggacgaaggcatggatgaggagaag ccccgaaacatgagcatgcccaccagtgagaccgagtccgtcaacaccgaaaacgtggct ggaggtgacatcgagggagaaaactgcggggccaggctggcccaccggatctccaagtca aagttcagccgctactggcgccggtggaatcggttctgcagaaggaagtgccgcgccgca gtcaagtctaatgtcttctactggctggtgattttcctggtgttcctcaacacgctcacc attgcctctgagcactacaaccagcccaactggctcacagaagtccaagacacggcaaac aaggccctgctggccctgttcacggcagagatgctcctgaagatgtacagcctgggcctg caggcctacttcgtgtccctcttcaaccgctttgactgcttcgtcgtgtgtggcggcatc ctggagaccatcctggtggagaccaagatcatgtccccactgggcatctccgtgctcaga tgcgtccggctgctgaggattttcaagatcacgaggtactggaactccttgagcaacctg gtggcatccttgctgaactctgtgcgctccatcgcctccctgctccttctcctcttcctc ttcatcatcatcttctccctcctggggatgcagctctttggaggaaagttcaactttgat gagatgcagacccggaggagcacattcgataacttcccccagtccctcctcactgtgttt cagatcctgaccggggaggactggaattcggtgatgtatgatgggatcatggcttatggc ggcccctcttttccagggatgttagtctgtatttacttcatcatcctcttcatctgtgga aactatatcctactgaatgtgttcttggccattgctgtggacaacctggctgatgctgag agcctcacatctgcccaaaaggaggaggaagaggagaaggagagaaagaagctggccagg actgccagcccagagaagaaacaagagttggtggagaagccggcagtgggggaatccaag gaggagaagattgagctgaaatccatcacggctgacggagagtctccacccgccaccaag atcaacatggatgacctccagcccaatgaaaatgaggataagagcccctaccccaaccca gaaactacaggagaagaggatgaggaggagccagagatgcctgtcggccctcgcccacga ccactctctgagcttcaccttaaggaaaaggcagtgcccatgccagaagccagcgcgttt ttcatcttcagctctaacaacaggtttcgcctccagtgccaccgcattgtcaatgacacg atcttcaccaacctgatcctcttcttcattctgctcagcagcatttccctggctgctgag gacccggtccagcacacctccttcaggaaccatattctgttttattttgatattgttttt accaccattttcaccattgaaattgctctgaagatgactgcttatggggctttcttgcac aagggttctttctgccggaactacttcaacatcctggacctgctggtggtcagcgtgtcc ctcatctcctttggcatccagtccagtgcaatcaatgtcgtgaagatcttgcgagtcctg cgagtactcaggcccctgagggccatcaacagggccaaggggctaaagcatgtggttcag tgtgtgtttgtcgccatccggaccatcgggaacatcgtgattgtcaccaccctgctgcag ttcatgtttgcctgcatcggggtccagctcttcaagggaaagctgtacacctgttcagac agttccaagcagacagaggcggaatgcaagggcaactacatcacgtacaaagacggggag gttgaccaccccatcatccaaccccgcagctgggagaacagcaagtttgactttgacaat gttctggcagccatgatggccctcttcaccgtctccaccttcgaagggtggccagagctg ctgtaccgctccatcgactcccacacggaagacaagggccccatctacaactaccgtgtg gagatctccatcttcttcatcatctacatcatcatcatcgccttcttcatgatgaacatc ttcgtgggcttcgtcatcgtcacctttcaggagcagggggagcaggagtacaagaactgt gagctggacaagaaccagcgacagtgcgtggaatacgccctcaaggcccggcccctgcgg aggtacatccccaagaaccagcaccagtacaaagtgtggtacgtggtcaactccacctac ttcgagtacctgatgttcgtcctcatcctgctcaacaccatctgcctggccatgcagcac tacggccagagctgcctgttcaaaatcgccatgaacatcctcaacatgctcttcactggc ctcttcaccgtggagatgatcctgaagctcattgccttcaaacccaagcactatttctgt gatgcatggaatacatttgacgccttgattgttgtgggtagcattgttgatatagcaatc accgaggtaaacccagctgaacatacccaatgctctccctctatgaacgcagaggaaaac tcccgcatctccatcaccttcttccgcctgttccgggtcatgcgtctggtgaagctgctg agccgtggggagggcatccggacgctgctgtggaccttcatcaagtccttccaggccctg ccctatgtggccctcctgatcgtgatgctgttcttcatctacgcggtgatcgggatgcag gtgtttgggaaaattgccctgaatgataccacagagatcaaccggaacaacaactttcag accttcccccaggccgtgctgctcctcttcaggtgtgccaccggggaggcctggcaggac atcatgctggcctgcatgccaggcaagaagtgtgccccagagtccgagcccagcaacagc acggagggtgaaacaccctgtggtagcagctttgctgtcttctacttcatcagcttctac atgctctgtgccttcctgatcatcaacctctttgtagctgtcatcatggacaactttgac tacctgacaagggactggtccatccttggtccccaccacctggatgagtttaaaagaatc tgggcagagtatgaccctgaagccaagggtcgtatcaaacacctggatgtggtgaccctc ctccggcggattcagccgccactaggttttgggaagctgtgccctcaccgcgtggcttgc aaacgcctggtctccatgaacatgcctctgaacagcgacgggacagtcatgttcaatgcc accctgtttgccctggtcaggacggccctgaggatcaaaacagaagggaacctagaacaa gccaatgaggagctgcgggcgatcatcaagaagatctggaagcggaccagcatgaagctg ctggaccaggtggtgccccctgcaggtgatgatgaggtcaccgttggcaagttctacgcc acgttcctgatccaggagtacttccggaagttcaagaagcgcaaagagcagggccttgtg ggcaagccctcccagaggaacgcgctgtctctgcaggctggcttgcgcacactgcatgac atcgggcctgagatccgacgggccatctctggagatctcaccgctgaggaggagctggac aaggccatgaaggaggctgtgtccgctgcttctgaagatgacatcttcaggagggccggt ggcctgttcggcaaccacgtcagctactaccaaagcgacggccggagcgccttcccccag accttcaccactcagcgcccgctgcacatcaacaaggcgggcagcagccagggcgacact gagtcgccatcccacgagaagctggtggactccaccttcaccccgagcagctactcgtcc accggctccaacgccaacatcaacaacgccaacaacaccgccctgggtcgcctccctcgc cccgccggctaccccagcacggtcagcactgtggagggccacgggccccccttgtcccct gccatccgggtgcaggaggtggcgtggaagctcagctccaacaggtgccactcccgggag agccaggcagccatggcgggtcaggaggagacgtctcaggatgagacctatgaagtgaag atgaaccatgacacggaggcctgcagtgagcccagcctgctctccacagagatgctctcc taccaggatgacgaaaatcggcaactgacgctcccagaggaggacaagagggacatccgg caatctccgaagaggggtttcctccgctctgcctcactaggtcgaagggcctccttccac ctggaatgtctgaagcgacagaaggaccgagggggagacatctctcagaagacagtcctg cccttgcatctggttcatcatcaggcattggcagtggcaggcctgagccccctcctccag agaagccattcccctgcctcattccctaggccttttgccaccccaccagccacacctggc agccgaggctggcccccacagcccgtccccaccctgcggcttgagggggtcgagtccagt gagaaactcaacagcagcttcccatccatccactgcggctcctgggctgagaccaccccc ggtggcgggggcagcagcgccgcccggagagtccggcccgtctccctcatggtgcccagc caggctggggccccagggaggcagttccacggcagtgccagcagcctggtggaagcggtc ttgatttcagaaggactggggcagtttgctcaagatcccaagttcatcgaggtcaccacc caggagctggccgacgcctgcgacatgaccatagaggagatggagagcgcggccgacaac atcctcagcgggggcgccccacagagccccaatggcgccctcttaccctttgtgaactgc agggacgcggggcaggaccgagccgggggcgaagaggacgcgggctgtgtgcgcgcgcgg ggtcgaccgagtgaggaggagctccaggacagcagggtctacgtcagcagcctgtag |
Protein Sequence |
>775 : length: 2138 MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISI VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIA YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN QEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVA GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLT IASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGI LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR TASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNP ETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDT IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLH KGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQ CVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGE VDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRV EISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLR RYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTG LFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ VFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRI WAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNA TLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYA TFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELD KAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDT ESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSP AIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS YQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVL PLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESS EKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAV LISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNC RDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL |