Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1051

Name

CEBPB

Synonymous

C/EBP-beta|CRP2|IL6DBP|LAP|NF-IL6|TCF5;CCAAT/enhancer binding protein (C/EBP), beta;CEBPB;CCAAT/enhancer binding protein (C/EBP), beta

Definition

CCAAT/enhancer-binding protein beta|TCF-5|interleukin 6-dependent DNA-binding protein|liver-enriched transcriptional activator protein|nuclear factor NF-IL6|nuclear factor of interleukin 6|transcription factor 5

Position

20q13.1

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for CEBPB

Transcription Factors   [Top]

Regulation From TransFac database

C/EBPbeta(h) --> ANTG(r) (DNA binding).
C/EBPbeta(h) --> CRP(h) (DNA binding; transregulation).
C/EBPbeta(h) --> HIV-1(HIV1) (DNA binding; transregulation).
C/EBPbeta(h) --> IL6(h) (DNA binding; transregulation).
C/EBPbeta(h) --> SAA1(r) (DNA binding).
C/EBPbeta(h) --> TSG-6(h) (DNA binding; transregulation).
C/EBPbeta(h) --> SAA2(h) (DNA binding; transregulation).
C/EBPbeta(h) --> ABCB1(h) (DNA binding; transregulation).
C/EBPbeta(h) --> SPINK1(h) (DNA binding).
C/EBPbeta(h) --> TOP1(h) (DNA binding; transregulation).
C/EBPbeta(h) --> CYP19A1(h) (DNA binding).
C/EBPbeta(h) --> IL1B(h) (DNA binding; transactivation).
C/EBPbeta(h) --> ICAM1(h) (DNA binding).
C/EBPbeta(h) --> CYP2D5(r) (DNA binding; transregulation).
C/EBPbeta(h) --> CCL5(h) (DNA binding).
C/EBPbeta(h) --> Kng2(r) (DNA binding; transregulation).
C/EBPalpha(h) + C/EBPbeta(h) <==> C/EBPalpha(h):C/EBPbeta(h) (binding).
C/EBPbeta(h) + C/EBPalpha(r) <==> C/EBPbeta(h):C/EBPalpha(r) (binding).
C/EBPbeta(h) + c-Fos(h) <==> C/EBPbeta(h):c-Fos(h) (binding).
CHOP-10(m) + C/EBPbeta(h) <==> CHOP-10(m):C/EBPbeta(h) (binding).
C/EBPbeta(h) + c-Jun(h) <==> C/EBPbeta(h):c-Jun(h) (binding).
C/EBPbeta(h) + pRb(h) <==> C/EBPbeta(h):pRb(h) (binding).
C/EBPbeta(h) + NF-kappaB1-p50(h) <==> C/EBPbeta(h):NF-kappaB1-p50(h) (binding).
C/EBPbeta(h) + RelA-p65(h) <==> C/EBPbeta(h):RelA-p65(h) (binding).
C/EBPbeta(h) --> SFTPD(h) (DNA binding; transactivation).
C/EBPbeta(h) --/ Gsta3(r) (DNA binding; transrepression).
C/EBPbeta(h) --> CDKN1A(h) (DNA binding).
C/EBPbeta(h) + C/EBPdelta(r) <==> C/EBPbeta(h):C/EBPdelta(r) (binding).
C/EBPbeta(h) + C/EBPdelta(h) <==> C/EBPbeta(h):C/EBPdelta(h) (binding).
C/EBPbeta(h) + C/EBPdelta(m) <==> C/EBPbeta(h):C/EBPdelta(m) (binding).
C/EBPbeta(h) + ATF-4(h) <==> C/EBPbeta(h):ATF-4(h) (binding).
NF-AT1(h) + C/EBPbeta(h) <==> NF-AT1(h):C/EBPbeta(h) (interaction; assembly; binding)
C/EBPbeta(h) --> IL18BP(h) (DNA binding; transactivation).
C/EBPbeta(h) --> MEFV(h) (DNA binding; transactivation).
C/EBPbeta(h) --> IL10(h) (DNA binding; transactivation).
C/EBPbeta(h) --> BCL2A1(h) (DNA binding; transactivation).
C/EBPbeta(h) --/ TFF1(h) (transrepression)
C/EBPbeta(h) --/ TFF2(h) (transrepression)
C/EBPbeta(h) --/ TFF3(h) (transrepression)
C/EBPbeta(h) --> Dlx-3(m) (DNA binding).
C/EBPbeta(h) --> LBP(h) (DNA binding)
p300(h) + C/EBPbeta(h) <==> p300(h):C/EBPbeta(h) (binding)
C/EBPbeta(h) + c-Myb(m) <==> C/EBPbeta(h):c-Myb(m) (binding)
C/EBPbeta(h) --> LECT2(c) (transactivation)
C/EBPbeta(h) + Cdk8(h) <==> C/EBPbeta(h):Cdk8(h) (binding)
CRSP70(h) + C/EBPbeta(h) <==> CRSP70(h):C/EBPbeta(h) (binding)
CA150(h) + C/EBPbeta(h) <==> CA150(h):C/EBPbeta(h) (binding)
C/EBPbeta(h) --> G6pc(r) (DNA binding).
C/EBPbeta(h) + ATP --> C/EBPbeta(h){p} + ADP (phosphorylation)
C/EBPbeta(h) --> PTGS2(h) (DNA binding).
C/EBPbeta(h) --> Foxf1a(m) (DNA binding; transactivation).
C/EBPbeta(h) --> SLC19A1(h) (DNA binding).
C/EBPbeta(h) --> S100A9(h) (DNA binding).
C/EBPbeta(h) --> Sox6(h) (DNA binding).
C/EBPbeta(h) --> SERPINE1(h) (DNA binding).
C/EBPbeta(h) --> CYP2A13(h) (DNA binding).
C/EBPbeta(h) --> HSD17B8(h) (DNA binding).
Trib1(h) + C/EBPbeta(h) <==> Trib1(h):C/EBPbeta(h) (binding)
C/EBPbeta(h) + ER-alpha(h) <==> C/EBPbeta(h):ER-alpha(h) (binding)
C/EBPbeta(h) --> FGFR2(h) (DNA binding).
C/EBPbeta(h) --> F7(h) (DNA binding).
C/EBPbeta(h) --> PRLR(h) (DNA binding).
C/EBPbeta(h) --> CCL3(h) (DNA binding).
C/EBPbeta(h) --> BCL2(h) (transactivation)
C/EBPbeta(h) --> LDLR(h) (transactivation)
C/EBPbeta(h) --> Bglap2(m) (DNA binding).
C/EBPbeta(h) --> Sfpi1(m) (DNA binding).
C/EBPbeta(h) --> TNFRSF10B(h) (DNA binding).
C/EBPbeta(h) --> CYP27B1(h) (DNA binding).
C/EBPbeta(h) --> FGFBP1(h) (transactivation)
C/EBPbeta(h) --> PRL(r) (transactivation)
p53(h) + C/EBPbeta(h) <==> p53(h):C/EBPbeta(h) (binding)
C/EBPbeta(h) --> G-CSF(h) (DNA binding).
C/EBPbeta(h) --> IL-5(h) (DNA binding).
C/EBPbeta(h) --> IL8(h) (DNA binding).
C/EBPbeta(h) --> STAR(h) (DNA binding; transactivation).
C/EBPbeta(h) --> CCR5(h) (DNA binding).
C/EBPbeta(h) --> TRAF3IP2(h) (DNA binding).
C/EBPbeta(h) --> CES1(h) (DNA binding; transactivation).
C/EBPbeta(h) --> FCAR(h) (DNA binding).
C/EBPbeta(h) --> CHIT1(h) (DNA binding).
DRIP205(m.s.) + C/EBPbeta(h) <==> DRIP205(m.s.):C/EBPbeta(h) (binding)
C/EBPbeta(h) --> MMP1(h) (DNA binding).
C/EBPbeta(h) --> SAA1(h) (DNA binding).
C/EBPbeta(h) --> INSR(h) (DNA binding).
C/EBPbeta(h) --> IL1RN(h) (DNA binding).
C/EBPbeta(h) --> Abcb1b(m) (DNA binding).
C/EBPbeta(h) --> CD14(h) (DNA binding; transactivation).
C/EBPbeta(h) --> Clec4e(m) (DNA binding; transactivation).
C/EBPbeta(h) + ATP --> C/EBPbeta(h){pT235} + ADP (phosphorylation)
C/EBPbeta(h) --> NOS2(h) (DNA binding; transactivation).
C/EBPbeta(h) --> DUSP1(h) (DNA binding).
C/EBPbeta(h) --> G-CSF(m) (DNA binding).
C/EBPbeta(h) --> HP(h) (DNA binding).
C/EBPbeta(h) --> LYS(c) (DNA binding).
C/EBPbeta(h) --> TNF(h) (DNA binding).
C/EBPbeta(h) --> PRTN3(h) (DNA binding).
C/EBPbeta(h) --> DEFA1(h) (DNA binding).
C/EBPbeta(h) --> DEFA3(h) (DNA binding).
C/EBPbeta(h) --> SLC11A1(h) (DNA binding).
C/EBPbeta(h) --> LCN2(h) (DNA binding).
C/EBPbeta(h) --> PLAC1(h) (DNA binding).
CEBPB(h) --> C/EBPbeta(h) (expression).
EGF(h) --> C/EBPbeta(h) (increase of abundance)
IL-6(m.s.) --> C/EBPbeta(h) (increase of abundance)
TNF-alpha(m.s.) --> C/EBPbeta(h) (increase of abundance)
IL-17A(h) --> C/EBPbeta(h) (increase of abundance)
NF-IL6-1(h) + TAF(II)31(h) <==> NF-IL6-1(h):TAF(II)31(h) (binding)
POU2F1(m.s.) + NF-IL6-1(h) <==> POU2F1(m.s.):NF-IL6-1(h) (binding)
p53-isoform1(h) + NF-IL6-1(h) <==> p53-isoform1(h):NF-IL6-1(h) (binding)
NF-IL6-1(h) + p53(h) <==> NF-IL6-1(h):p53(h) (binding)
NF-IL6-1(h) --> prl(h) (transactivation)
NF-IL6-1(h) + PR B(h) <==> NF-IL6-1(h):PR B(h) (binding)
PR A(h) + NF-IL6-1(h) <==> PR A(h):NF-IL6-1(h) (binding)
GABP-alpha(h) + NF-IL6-1(h) <==> GABP-alpha(h):NF-IL6-1(h) (binding)
NF-IL6-1(h) + C/EBPalpha(h) <==> NF-IL6-1(h):C/EBPalpha(h) (binding)
2 NF-IL6-1(h) <==> (NF-IL6-1(h))2 (binding)
NF-IL6-1(h) + C/EBPgamma(h) <==> NF-IL6-1(h):C/EBPgamma(h) (binding)
NF-IL6-1(h) + C/EBPdelta(h) <==> NF-IL6-1(h):C/EBPdelta(h) (binding)
cebpe(h) + NF-IL6-1(h) <==> NF-IL6-1(h):cebpe(h) (binding)
NF-IL6-1(h) + CHOP-10(h) <==> NF-IL6-1(h):CHOP-10(h) (binding)
NF-IL6-1(h) + ATFa-isoform3(h) <==> NF-IL6-1(h):ATFa-isoform3(h) (binding)
NF-IL6-1(h) + ATF-4(h) <==> NF-IL6-1(h):ATF-4(h) (binding)
NF-IL6-1(h) + ATF5(h) <==> NF-IL6-1(h):ATF5(h) (binding)
NF-IL6-1(h) + B-ATF(h) <==> NF-IL6-1(h):B-ATF(h) (binding)
NF-IL6-1(h) + batf3(h) <==> NF-IL6-1(h):batf3(h) (binding)
NF-IL6-1(h) + DBP(h) <==> NF-IL6-1(h):DBP(h) (binding)
NF-IL6-1(h) + CREBPA-Alpha(h) <==> NF-IL6-1(h):CREBPA-Alpha(h) (binding)
NF-IL6-1(h) + Egr-1(m) <==> NF-IL6-1(h):Egr-1(m) (binding)
NF-IL6-1(h) --> LDLR(h) (transactivation)
NF-IL6-1(h) + ATP --> NF-IL6-1(h){pT235} + ADP (phosphorylation)
CEBPB(h) --> NF-IL6-1(h) (expression).
NF-IL6-3(h) --/ TSG-6(h) (DNA binding; transrepression).
POU2F1(m.s.) + NF-IL6-3(h) <==> POU2F1(m.s.):NF-IL6-3(h) (binding)
POU2F1(m.s.) + Oct-2(m.s.) + NF-IL6-3(h) <==> POU2F1(m.s.):Oct-2(m.s.):NF-IL6-3(h) (binding)
NF-IL6-3(h) + PR A(h) <==> NF-IL6-3(h):PR A(h) (binding)
PR B(h) + NF-IL6-3(h) <==> PR B(h):NF-IL6-3(h) (binding)
NF-IL6-3(h) + GR-alpha(h) <==> NF-IL6-3(h):GR-alpha(h) (binding)
p53-isoform1(h) + NF-IL6-3(h) <==> p53-isoform1(h):NF-IL6-3(h) (binding)
CEBPB(h) --> NF-IL6-3(h) (expression).
CEBPB(h) --> NF-IL6-2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

174Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
266Phosphothreonine (RSK-1)10635333Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr20

 Promoter: 48239283 - 48241283Agilent_014791

chr20

 Promoter: 48239283 - 48241283GSE27584

chr20

 Promoter: 48239283 - 48241283Agilent_014791_44K

')