| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1499 |
Name | CTNNB1 |
Synonymous | CTNNB|MRD19|armadillo;catenin (cadherin-associated protein), beta 1, 88kDa;CTNNB1;catenin (cadherin-associated protein), beta 1, 88kDa |
Definition | catenin beta-1 |
Position | 3p21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for CTNNB1 | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
alpha-catenin1(m) + beta-catenin(h) <==> alpha-catenin1(m):beta-catenin(h) (binding) | apc(h) + beta-catenin(h) <==> apc(h):beta-catenin(h) (binding) | beta-catenin(h) + apc(h) + alpha-catenin1(m) <==> alpha-catenin1(m):beta-catenin(h):apc(h) (binding) | axin(m) + beta-catenin(h) <==> axin(m):beta-catenin(h) (binding) | apc(h) + axin(h) + beta-catenin(h) <==> apc(h):axin(h):beta-catenin(h) (binding) | beta-catenin(h) + ATP --GSK3beta(h)--> beta-catenin(h){p} + ADP (phosphorylation) | axin(m) + beta-catenin(h) + GSK3beta(h) <==> axin(m):beta-catenin(h):GSK3beta(h) (binding) | alpha-catenin1(h) + beta-catenin(h) + E-cadherin(h) + p120CAS(h) + plakoglobin(h) <==> alpha-catenin1(h):beta-catenin(h):E-cadherin(h):plakoglobin(h):p120CAS(h) (binding) | alpha-catenin1(h) + beta-catenin(h) <==> alpha-catenin1(h):beta-catenin(h) (binding) | alpha-catenin1(h) + apc(h) + beta-catenin(h) + plakoglobin(h) <==> alpha-catenin1(h):apc(h):beta-catenin(h):plakoglobin(h) (binding) | beta-catenin(h) + muc1(h) <==> beta-catenin(h):muc1(h) (binding; competition) | beta-catenin(h) + E-cadherin(h) <==> beta-catenin(h):E-cadherin(h) (binding) | ErbB2(h) + beta-catenin(h) <==> beta-catenin(h):ErbB2(h) (binding) | PS1(h) + beta-catenin(h) <==> beta-catenin(h):PS1(h) (binding) | beta-catenin(h) + axin(h) <==> axin(h):beta-catenin(h) (binding) | apc(h) + axin(h) + beta-catenin(h) + GSK3beta(h) <==> apc(h):axin(h):beta-catenin(h):GSK3beta(h) (binding) | beta-catenin(h) + conductin(h) <==> beta-catenin(h):conductin(h) (binding) | beta-catenin(h) + p85alpha(h) <==> beta-catenin(h):p85alpha(h) (binding) | beta-catenin(h) + Sox17beta(x) <==> beta-catenin(h):Sox17beta(x) (binding) | beta-catenin(h) + Sox17alpha(x) <==> beta-catenin(h):Sox17alpha(x) (binding) | beta-catenin(h) + Sox3(x) <==> beta-catenin(h):Sox3(x) (binding) | beta-catenin(h) + HOS(h) <==> beta-catenin(h):HOS(h) (binding) | beta-catenin(h) + Cul-1(h){nedd} <==> beta-catenin(h):Cul-1(h){nedd} (binding) | beta-catenin(h) + beta-TrCP1(h) <==> beta-catenin(h):beta-TrCP1(h) (binding) | apc(h) + beta-catenin(h) + beta-TrCP1(h) <==> apc(h):beta-catenin(h):beta-TrCP1(h) (binding) | beta-catenin(h) + Ebi(h) <==> beta-catenin(h):Ebi(h) (binding) | beta-catenin(h) + Su(fu)(m) <==> beta-catenin(h):Su(fu)(m) (binding) | LEF-1(m) + beta-catenin(h) <==> LEF-1(m):beta-catenin(h) (binding). | TCF-3C(x) + beta-catenin(h) <==> TCF-3C(x):beta-catenin(h) (binding). | TCF-3D(x) + beta-catenin(h) <==> TCF-3D(x):beta-catenin(h) (binding). | Pontin52(h) + beta-catenin(h) <==> Pontin52(h):beta-catenin(h) (binding). | TCF-4E(h) + beta-catenin(h) <==> TCF-4E(h):beta-catenin(h) (binding). | TCF-4B(h) + beta-catenin(h) <==> TCF-4B(h):beta-catenin(h) (binding). | TCF-1(P)(m) + beta-catenin(h) <==> TCF-1(P)(m):beta-catenin(h) (binding). | TCF-3(x) + beta-catenin(h) <==> TCF-3(x):beta-catenin(h) (binding). | LEF1-isoform1(h) + beta-catenin(h) <==> LEF1-isoform1(h):beta-catenin(h) (binding) | beta-catenin(h) + smad4(h) <==> beta-catenin(h):smad4(h) (binding) | beta-catenin(h) + Smad3(h) <==> beta-catenin(h):Smad3(h) (binding) | TCF-4(h) + beta-catenin(h) <==> TCF-4(h):beta-catenin(h) (binding) | beta-catenin(h) + E-cadherin-CTF2(h) <==> beta-catenin(h):E-cadherin-CTF2(h) (binding) | beta-catenin(h) + GTP --CKII(v.s.)--> beta-catenin(h){pS29}{pT393} + GDP (phosphorylation) | beta-catenin(h) + TCF-4(h) + NLK(m) <==> beta-catenin(h):TCF-4(h):NLK(m) (binding) | beta-catenin(h) + ATP --CKI-delta(h)--> beta-catenin(h){p} + ADP (phosphorylation) | axin(h) + GSK3beta(h) + PR65(h) + PP2ACalpha(h) + beta-catenin(h) <==> axin(h):beta-catenin(h):GSK3beta(h):PP2ACalpha(h):PR65(h) (binding) | beta-catenin(h) + axin(x) <==> axin(x):beta-catenin(h) (binding) | beta-catenin(h) + apc(h){p} <==> apc(h){p}:beta-catenin(h) (binding) | RXR-alpha(h) + beta-catenin(h) <==> beta-catenin(h):RXR-alpha(h) (binding) | beta-catenin(h) + plakoglobin(h) + TCF-4(h) <==> beta-catenin(h):TCF-4(h):plakoglobin(h) (binding) | beta-catenin(h) + TCF-4(h){pS60} <==> beta-catenin(h):TCF-4(h){pS60} (binding) | beta-catenin(h) + axin(m){pT609}{pS614}{pS621} <==> axin(m){pT609}{pS614}{pS621}:beta-catenin(h) (binding) | beta-catenin(h) + Reptin52(h) <==> beta-catenin(h):Reptin52(h) (binding) | Tip60(h) + Bcl-3(h) + beta-catenin(h) + Reptin52(h) <==> Bcl-3(h):beta-catenin(h):Reptin52(h):Tip60(h) (binding) | Reptin52(h) + NF-kappaB1-p50(h):NF-kappaB1-p50(h) + beta-catenin(h) + Bcl-3(h) <==> Bcl-3(h):beta-catenin(h):NF-kappaB1-p50(h):NF-kappaB1-p50(h):Reptin52(h) (binding) | beta-catenin(h) --PUMA(m.s.)--> protein remnants (increase of cleavage) | DSC3(h) + beta-catenin(h) <==> DSC3(h):beta-catenin(h) (binding) | MAGI-1-isoform2(m) + beta-catenin(h) <==> MAGI-1-isoform2(m):beta-catenin(h) (binding) | calcitriol:VDR(h) + beta-catenin(h) <==> calcitriol:VDR(h):beta-catenin(h) (binding) | beta-catenin(h) + TIF2(h) <==> beta-catenin(h):TIF2(h) (binding) | 5alphaDHT:AR(h) + beta-catenin(h) <==> 5alphaDHT:AR(h):beta-catenin(h) (binding) | 5alphaDHT:AR(m.s.) + beta-catenin(h) <==> 5alphaDHT:AR(m.s.):beta-catenin(h) (regulation of localization; binding) | beta-catenin(h) --> AR(h) (activation) | p63alpha(h) + beta-catenin(h) <==> p63alpha(h):beta-catenin(h) (binding) | beta-catenin(h) + 3 ATP --> beta-catenin(h){pS33}{pS37}{pT41} + 3 ADP (phosphorylation) | PS1(m.s.) + beta-catenin(h) <==> PS1(m.s.):beta-catenin(h) (binding) | PS1(m.s.) + TCF-4(m.s.) + beta-catenin(h) <==> PS1(m.s.):TCF-4(m.s.):beta-catenin(h) (binding) | TCF-4(m.s.) + beta-catenin(h) <==> TCF-4(m.s.):beta-catenin(h) (binding) | actin(h) + vimentin(h) + plakoglobin(h) + beta-catenin(h) + alpha-catenin(h) + VE-cadherin(h) <==> actin(h):vimentin(h):plakoglobin(h):beta-catenin(h):alpha-catenin(h):VE-cadherin(h) (binding) | plakoglobin(h) + alpha-catenin(h) + beta-catenin(h) + VE-cadherin(h) <==> plakoglobin(h):alpha-catenin(h):beta-catenin(h):VE-cadherin(h) (binding) | beta-catenin(h) + plakoglobin(h) + vimentin(h) + VE-cadherin(h) <==> beta-catenin(h):plakoglobin(h):vimentin(h):VE-cadherin(h) (binding) | beta-catenin(h) --> beta-catenin(h) (translocation) | N-cadherin-CTF2(h) + beta-catenin(h) <==> N-cadherin-CTF2(h):beta-catenin(h) (binding) | TCF-4(h) + beta-catenin(h) + HIC-1(h) <==> TCF-4(h):beta-catenin(h):HIC-1(h) (binding) | Ecalectin(h) + beta-catenin(h) <==> Ecalectin(h):beta-catenin(h) (binding) | ICAT(h) + beta-catenin(h) <==> ICAT(h):beta-catenin(h) (binding) | prohibitin-2(h) + beta-catenin(h) <==> prohibitin-2(h):beta-catenin(h) (binding) | GSK3beta(h) + beta-catenin(h) <==> GSK3beta(h):beta-catenin(h) (binding) | beta-catenin(h) + ubiquitin(h) --> beta-catenin(h){ub} (ubiquitination) | beta-catenin(h) + Smad7(m.s.) <==> beta-catenin(h):Smad7(m.s.) (binding) | beta-catenin(h) + Smurf-2(h) <==> beta-catenin(h):Smurf-2(h) (binding) | Smad7(m.s.) + axin(m.s.) + GSK3beta(h) + beta-catenin(h) + apc(h) + CKI(h) <==> Smad7(m.s.):axin(m.s.):GSK3beta(h):beta-catenin(h):apc(h):CKI(h) (binding) | beta-catenin(h) + 4 ATP --> beta-catenin(h){pS33}{pS37}{pT41}{pS45} + 4 ADP (phosphorylation) | Nek2(h) + beta-catenin(h) <==> Nek2(h):beta-catenin(h) (binding) | Nek2(m.s.) + beta-catenin(h) <==> Nek2(m.s.):beta-catenin(h) (binding) | beta-catenin(h) --> NOS2(h) (DNA binding). | beta-catenin(h) + ATP --> beta-catenin(h){pY} + ADP (phosphorylation) | beta-catenin(h) + 2 ATP --> beta-catenin(h){pS}{pT} + 2 ADP (phosphorylation) | beta-catenin(h) + ATP --> beta-catenin(h){pS45} + ADP (phosphorylation) | beta-catenin(h) --26S proteasome(h)--> protein remnants (degradation) | beta-catenin(h) + VE-cadherin(h) <==> beta-catenin(h):VE-cadherin(h) (binding) | Dpr1(h) + beta-catenin(h) <==> Dpr1(h):beta-catenin(h) (binding) | Dpr1(h) + beta-catenin(h) <==> Dpr1(h):beta-catenin(h) (binding) | beta-catenin(h) + BGPI-A(h) <==> beta-catenin(h):BGPI-A(h) (binding) | Sox17(h) + beta-catenin(h) <==> Sox17(h):beta-catenin(h) (binding) | beta-catenin(h) + Sox17(m) <==> beta-catenin(h):Sox17(m) (binding) | CTNNB1(h) --> beta-catenin(h) (expression). | E-cadherin(m.s.) --> beta-catenin(h) (regulation of localization) | Wnt-3A(m.s.) --> beta-catenin(h) (increase of abundance; activation) | Wnt-3A(m.s.) --> beta-catenin(h) (regulation of localization) | p110alpha(m.s.) --> beta-catenin(h) (regulation of localization; stabilization) | beta-catenin(h) --> beta-catenin(h) (translocation) | muc1(h) --> beta-catenin(h) (increase of abundance) | beta-catenin(h){pS33}{pS37} --> beta-catenin(h) + 2 p (dephosphorylation) | Smad7(m.s.) --> beta-catenin(h) (increase of abundance) | MKK6(m) --> beta-catenin(h) (increase of abundance) | GSK3beta(m){pS389} --> beta-catenin(h) (increase of abundance) | CHIP(h) --/ beta-catenin(h) (decrease of abundance) | Wnt-3A(m.s.) --> beta-catenin(h) (increase of abundance) | Dkk-1(h) --/ beta-catenin(h) (decrease of abundance) | En-1(h) --/ beta-catenin(h) (decrease of abundance) | En-1(h) --/ beta-catenin(h) (decrease of abundance) | Siah1(m.s.) --/ beta-catenin(h) (decrease of abundance) | TCF-4(h) + beta-catenin(h) <==> TCF-4(h):beta-catenin(h) (binding) | beta-catenin(h) --> CDX2(h) (transactivation) | beta-catenin(h) --> Cdx-2(h) (increase of abundance) | alpha-catenin1(m.s.) + beta-catenin(h) <==> alpha-catenin1(m.s.):beta-catenin(h) (binding) | beta-catenin(h) --> GLCE(h) (transactivation) | Sox17(h) + beta-catenin(h) <==> Sox17(h):beta-catenin(h) (binding) | Sox17(m) + beta-catenin(h) <==> Sox17(m):beta-catenin(h) (binding) | TCF-4(h) + Sox17(m) + beta-catenin(h) <==> TCF-4(h):Sox17(m):beta-catenin(h) (binding) | Sox17(m) + TCF-3(x) + beta-catenin(h) <==> Sox17(m):TCF-3(x):beta-catenin(h) (binding) | beta-catenin(h) + Sox4(m) <==> beta-catenin(h):Sox4(m) (binding) | CTNNB1(h) --> beta-catenin(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
23 | Phosphoserine (by GSK3-beta). | Swiss-Prot 53.0 | 29 | Phosphoserine (by GSK3-beta). | Swiss-Prot 53.0 | 33 | Phosphoserine (by GSK3-beta). | Swiss-Prot 53.0 | 37 | Phosphoserine (by GSK3-beta). | Swiss-Prot 53.0 | 41 | Phosphothreonine (by GSK3-beta). | Swiss-Prot 53.0 | 45 | Phosphoserine. | Swiss-Prot 53.0 | 86 | Phosphotyrosine (by CSK). | Swiss-Prot 53.0 | 191 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 551 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 552 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 556 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 654 | Phosphotyrosine (by CSK). | Swiss-Prot 53.0 | 675 | Phosphoserine. | Swiss-Prot 53.0 | 86 | Phosphotyrosine (Src) | 11279024 | Phospho.ELM 6.0 | 142 | Phosphotyrosine (Fyn) | 12640114 | Phospho.ELM 6.0 | 654 | Phosphotyrosine (Src) | 11279024 | Phospho.ELM 6.0 | 675 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr3 |
Promoter: 41214516 - 41216516 | Agilent_014791 |
chr3 |
Promoter: 41214516 - 41216516 | GoldenGate_Methylation_Cancer_Panel_I |
chr3 |
Promoter: 41214516 - 41216516 | GSE27584 |
chr3 |
Promoter: 41214516 - 41216516 | Agilent_014791_44K |
chr3 |
Promoter: 41214516 - 41216516 | Agilent_014791 |
chr3 |
Promoter: 41214516 - 41216516 | PMID:16956712 |
chr3 |
Promoter: 41214516 - 41216516 | PMID:16435073 |
chr3 |
Promoter: 41214516 - 41216516 | PMID:12796396 |