Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

185

Name

AGTR1

Synonymous

AG2S|AGTR1A|AGTR1B|AT1|AT1AR|AT1B|AT1BR|AT1R|AT2R1|AT2R1A|AT2R1B|HAT1R;angiotensin II receptor, type 1;AGTR1;angiotensin II receptor, type 1

Definition

type-1 angiotensin II receptor|type-1B angiotensin II receptor

Position

3q24

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for AGTR1

Transcription Factors   [Top]

Regulation From TransFac database

AT1A(h) --> STAT5(h) (phosphorylation)
AT1A(h) --> protein remnants (degradation)
AT1A(h) + n ubiquitin(h) --> AT1A(h){ub}n (ubiquitination)
AT1A(h) + DRD5(h) <==> AT1A(h):DRD5(h) (binding)
angiotensin II(h) --> AT1A(h) (activation)
AGTR1(h) --> AT1A(h) (expression).
AT1A(h) + beta-adaptin 2(h) <==> beta-adaptin 2(h):AT1A(h) (binding)
AT1A(h) + CHC(h) <==> AT1A(h):CHC(h) (binding)
AT1A(h) + ATRAP-isoform1(h) <==> AT1A(h):ATRAP-isoform1(h) (binding)
AT1A(h) + NDP-Gly --> AT1A(h){gly} + NMP (glycosylation)
AT1A(h) --> protein remnants (degradation)
AT1A(h) + n ubiquitin(h) --> AT1A(h){ub}n (ubiquitination)
angiotensin II(m.s.) + AT1A(h) <==> angiotensin II(m.s.):AT1A(h) (binding)
AGTR1(h) --> AT1A(h) (expression).
AGTR1(h) --> AGTR1(h) (expression).
hsa-miR-155 --/ AGTR1(h) (translational repression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

4N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
176N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
188N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
355S-palmitoyl cysteine (Potential).Swiss-Prot 53.0
319Phosphotyrosine12522132Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr3

Promoter: 149896848 - 149898848Agilent_014791

chr3

Promoter: 149896848 - 149898848GoldenGate_Methylation_Cancer_Panel_I

chr3

Promoter: 149896848 - 149898848GoldenGate_Methylation_Cancer_Panel_I

chr3

Promoter: 149896848 - 149898848GoldenGate_Methylation_Cancer_Panel_I

chr3

Promoter: 149896848 - 149898848GoldenGate_Methylation_Cancer_Panel_I

chr3

Promoter: 149896848 - 149898848GSE27584

chr3

Promoter: 149896848 - 149898848GSE27584

chr3

Promoter: 149896848 - 149898848GSE27584

chr3

Promoter: 149896848 - 149898848GSE27584

chr3

Promoter: 149896848 - 149898848Agilent_014791_44K


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