| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2022 |
Name | ENG |
Synonymous | CD105|END|HHT1|ORW|ORW1;endoglin;ENG;endoglin |
Definition | CD105 antigen |
Position | 9q34.11 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
|
Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr9:130577291-130617035 | chr9:130605385-130605385 | rs16930129 | Single_Nucleotides|eQTL|ENG, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|FAIRE|Nhbe, Chromatin_Structure|DNase-seq|Hepatocytes |
|---|---|---|---|
Transcription Factors [Top] |
|
Regulation From TransFac database |
TGFbetaR-I(h) + endoglin(h) <==> TGFbetaR-I(h):endoglin(h) (binding) | TGFbetaR-II(h) + endoglin(h) <==> TGFbetaR-II(h):endoglin(h) (binding) | endoglin(h) + ATP --TGFbetaR-I(h)--> endoglin(h){p} + ADP (phosphorylation) | endoglin(h) + ATP --TGFbetaR-II(h)--> endoglin(h){p} + ADP (phosphorylation) | endoglin(h) --> eNOS(h) (activation; increase of abundance) | endoglin(h) + Hsp90(h) + caveolin-1(h) + eNOS(h) <==> endoglin(h):Hsp90(h):caveolin-1(h):eNOS(h) (binding) | ENG(h) --> endoglin(h) (expression). | ENG(h) --> endoglin(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
88 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 102 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 121 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 134 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 307 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr9 |
Promoter: 129656305 - 129658305 | GSE27584 |
chr9 |
Promoter: 129656305 - 129658305 | Agilent_014791_44K |
chr9 |
Promoter: 129656305 - 129658305 | PMID:15911247 |
chr9 |
Promoter: 129656305 - 129658305 | PMID:16952549 |