| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2100 |
Name | ESR2 |
Synonymous | ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2;estrogen receptor 2 (ER beta);ESR2;estrogen receptor 2 (ER beta) |
Definition | estrogen nuclear receptor beta variant a|estrogen nuclear receptor beta variant b|estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2 |
Position | 14q23.2 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
|
Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr14:64550950-64804830 | chr14:64745399-64745399 | rs1256033 | Single_Nucleotides|eQTL|SYNE2, Chromatin_Structure|FAIRE|Htr8, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|FAIRE|H1hesc, Chromatin_Structure|FAIRE|UrotsaUt189 |
|---|---|---|---|
Transcription Factors [Top] |
|
Regulation From TransFac database |
ER-beta-isoform1(h) --> Vegfa(r) (DNA binding; transregulation). | ER-beta-isoform1(h) + ER-alpha(h) <==> ER-beta-isoform1(h):ER-alpha(h) (binding). | ER-beta-isoform1(h) + ER-beta-isoform1(h) <==> ER-beta-isoform1(h):ER-beta-isoform1(h) (binding). | ER-beta-isoform1(h) --> C3(h) (DNA binding). | ER-beta-isoform1(h) --> TFF1(h) (DNA binding). | ER-beta-isoform1(h) --> VIT-II(c) (DNA binding). | ER-beta-isoform1(h) --> CTSD(h) (DNA binding). | ER-beta-isoform1(h) --> NQO1(h) (DNA binding; transactivation). | ER-beta-isoform1(h) --> Jun(r) (DNA binding). | ER-beta-isoform1(h) --> Fos(m) (DNA binding). | ER-beta-isoform1(h) --> Chat(m) (DNA binding). | ER-beta-isoform1(h) + MSH-2(h) <==> ER-beta-isoform1(h):MSH-2(h) (binding) | ER-beta-isoform1(h) + SPF45(h) <==> ER-beta-isoform1(h):SPF45(h) (binding) | ESR2(h) --> ER-beta-isoform1(h) (expression). | ESR2(h) --> ER-beta-isoform2(h) (expression). | ESR2(h) --> ER-beta-isoform3(h) (expression). | ESR2(h) --> ER-beta-isoform4(h) (expression). | ESR2(h) --> ER-beta-isoform5(h) (expression). | ER-beta(h) + MRF1(h) <==> ER-beta(h):MRF1(h) (binding) | ER-beta(h) + RTA-isoform1(h) <==> ER-beta(h):RTA-isoform1(h) (binding) | BAF57(m) + ER-beta(h) <==> BAF57(m):ER-beta(h) (binding) | ER-beta(h) + estradiol <==> ER-beta(h):estradiol (binding) | ER-beta(h) + DP97-xbb2(h) <==> ER-beta(h):DP97-xbb2(h) (binding) | ER-beta(h) --> AR(h) (binding) | ER-beta(h) --> AR(h) (activation) | AKT-1(h) + ER-beta(h) <==> AKT-1(h):ER-beta(h) (binding) | AKT(h){pT308}{pS473} + ER-beta(h) <==> AKT(h){pT308}{pS473}:ER-beta(h) (binding) | GT198(r) + ER-beta(h) <==> GT198(r):ER-beta(h) (binding) | ER-beta(h) + COM1(h) <==> ER-beta(h):COM1(h) (binding) | ER-beta(h) + MNAR(h) <==> ER-beta(h):MNAR(h) (binding) | ER-beta(h) + MSH2(h) <==> ER-beta(h):MSH2(h) (binding) | 14-3-3eta(h) + ER-beta(h) <==> 14-3-3eta(h):ER-beta(h) (binding) | ER-beta(h) + DAP3(h) <==> ER-beta(h):DAP3(h) (binding) | p300(m.s.) + ER-beta(h) <==> p300(m.s.):ER-beta(h) (binding) | ER-beta(h) + SRC-1(h) <==> ER-beta(h):SRC-1(h) (binding) | ER-beta(h) + TIF2(h) <==> ER-beta(h):TIF2(h) (binding) | ER-beta(h) + SRC3(h) <==> ER-beta(h):SRC3(h) (binding) | ER-beta(h) --> INSR(h) (DNA binding). | NCOR1-isoform1(m) + ER-beta(h) <==> NCOR1-isoform1(m):ER-beta(h) (binding) | ER-beta(h) --/ CRHBP(h) (DNA binding; transrepression). | ASC-2(m) + ER-beta(h) <==> ASC-2(m):ER-beta(h) (binding) | ER-beta(h) --> Avp(r) (DNA binding) | ER-beta(h) --> prl(h) (DNA binding). | Smad3(m.s.) + ER-beta(h) <==> Smad3(m.s.):ER-beta(h) (binding) | Smad2(m.s.) + ER-beta(h) <==> Smad2(m.s.):ER-beta(h) (binding) | Smad4(m.s.) + ER-beta(h) <==> Smad4(m.s.):ER-beta(h) (binding) | ER-beta(h) --> VEGFA(h) (transactivation) | ER-beta(h) + palmityl-CoA --> ER-beta(h){pal} + CoA (palmitoylation) | ER-beta(h) --> C3(h) (transactivation) | ER-beta(h) --> SSTR2(h) (DNA binding). | ER-beta(h) --> BMP2(m) (transactivation) | ER-beta(h) --/ TNF(h) (transrepression) | PNRC(h) + ER-beta(h) <==> PNRC(h):ER-beta(h) (binding) | ER-beta(h) + PNRC2(h) <==> ER-beta(h):PNRC2(h) (binding) | PGC-1(h) + ER-beta(h) <==> PGC-1(h):ER-beta(h) (binding) | ER-beta(h) + ASC-2(h) <==> ER-beta(h):ASC-2(h) (binding) | ER-beta(h) + RIP140(h) <==> ER-beta(h):RIP140(h) (binding) | ER-beta(h) --> OVGP1(h) (DNA binding). | ESR2(h) --> ER-beta(h) (expression). | Src(h) --> ER-beta(h) (binding) | AR(h) --> ER-beta(h) (activation) | ESR2(h) --> ER-beta-isoform6(h) (expression). | ESR2(h) --> ER-beta-isoform7(h) (expression). | ESR2(h) --> ER-beta-isoform8(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
87 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 488 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 165 | Phosphoserine (RSK-1) | 9528769 | Phospho.ELM 6.0 | 105 | Phosphoserine | 15862947 | Phospho.ELM 6.0 | 87 | Phosphoserine | 15862947 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr14 |
Promoter: 63830381 - 63832381 | Agilent_014791 |
chr14 |
Promoter: 63830381 - 63832381 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 63830381 - 63832381 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 63830381 - 63832381 | GSE27584 |
chr14 |
Promoter: 63874521 - 63876521 | GSE27584 |
chr14 |
Promoter: 63830381 - 63832381 | GSE27584 |
chr14 |
Promoter: 63874521 - 63876521 | Agilent_014791_44K |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15254780 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:15254780 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15254780 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:16181550 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:16181550 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:16181550 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15536519 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:15536519 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15536519 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15172987 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:15172987 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15172987 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:16322330 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:16322330 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:16322330 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:16889486 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:16889486 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:16889486 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:11880477 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:11880477 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:11880477 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15161636 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:15161636 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15161636 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:11596023 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:11596023 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:11596023 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:11895880 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:11895880 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:11895880 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15639718 |
chr14 |
Promoter: 63874521 - 63876521 | PMID:15639718 |
chr14 |
Promoter: 63830381 - 63832381 | PMID:15639718 |